RESUMO
A total of 16 cases of congenital fibrosarcoma have been reported from 1975 to March 2015. Five of the 16 had abnormal fusion between erythroblast transformation specific translocation variant 6 and neurotrophin recptor gene neurotrophic tyrosine kinase, receptor, type 3 (ETV6-NTRK3); in another five out of 16 this was absent, and six were not tested. All were managed by surgical resection but none involved metastasis. Herein we report the case of a newborn baby girl with congenital fibrosarcoma negative for ETV6-NTRK3 gene fusion, who presented with ileal perforation and positive resection margin. She had rapid recurrence with lymph node metastasis treated with postoperative chemotherapy. There was no further recurrence at >3 years of follow up.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Fibrossarcoma/tratamento farmacológico , Neoplasias do Íleo/tratamento farmacológico , Intestino Delgado/cirurgia , Neoplasias do Jejuno/tratamento farmacológico , Recidiva Local de Neoplasia/tratamento farmacológico , Antineoplásicos/uso terapêutico , Quimioterapia Adjuvante , Colectomia , Feminino , Fibrossarcoma/congênito , Fibrossarcoma/patologia , Fibrossarcoma/cirurgia , Humanos , Neoplasias do Íleo/congênito , Neoplasias do Íleo/patologia , Neoplasias do Íleo/cirurgia , Recém-Nascido , Neoplasias do Jejuno/congênito , Neoplasias do Jejuno/patologia , Neoplasias do Jejuno/cirurgia , Metástase Linfática , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/cirurgiaRESUMO
Hyperreactio luteinalis is a benign, pregnancy-related condition with cystic enlargement of the ovaries and elevated androgen. However, only one-third of patients manifest as maternal virilisation and rarely does it cause fetal virilisation. Here, we report a virilised baby girl born to a virilised mother because of hyperreactio luteinalis. This case illustrates our management to maternal and fetal virilisation.
Assuntos
Cistos Ovarianos , Complicações na Gravidez , Gravidez , Feminino , Humanos , Mães , Cistos Ovarianos/diagnóstico por imagem , Cistos Ovarianos/cirurgia , Cistos Ovarianos/complicações , Virilismo/etiologiaRESUMO
A teenage girl presented with galactorrhoea and moderate hyperprolactinaemia. She was subsequently diagnosed to have acute lymphoblastic leukaemia. Further investigations supported the presence of ectopic prolactin production as suggested by the presence of prolactin mRNA in the patient's marrow at diagnosis. Both the ectopic prolactin mRNA and galactorrhoea eventually resolved upon disease remission after treatment.