Detalhe da pesquisa
1.
RIP3 induces apoptosis independent of pronecrotic kinase activity.
Mol Cell
; 56(4): 481-95, 2014 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25459880
2.
Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.
J Biol Chem
; 288(43): 31268-79, 2013 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24019532
3.
Pharmacological inhibition of C-C chemokine receptor 2 decreases macrophage infiltration in the aortic root of the human C-C chemokine receptor 2/apolipoprotein E-/- mouse: magnetic resonance imaging assessment.
Arterioscler Thromb Vasc Biol
; 30(2): 253-9, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19965779
4.
CCR2 receptor antagonists: optimization of biaryl sulfonamides to increase activity in whole blood.
Bioorg Med Chem Lett
; 21(24): 7291-4, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22047688
5.
Practical and scalable synthesis of a selective CCK1 receptor antagonist.
J Org Chem
; 75(22): 7950-3, 2010 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-20977279
6.
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
J Med Chem
; 62(10): 5096-5110, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013427
7.
Aminomethylpiperazines as selective urotensin antagonists.
Bioorg Med Chem Lett
; 18(16): 4470-3, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18674898
8.
Development of potent and selective small-molecule human Urotensin-II antagonists.
Bioorg Med Chem Lett
; 18(12): 3500-3, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18502123
9.
Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles.
Bioorg Med Chem Lett
; 18(13): 3716-9, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18524591
10.
Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.
J Med Chem
; 50(1): 6-9, 2007 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17201405
11.
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
J Med Chem
; 60(4): 1247-1261, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28151659
12.
Total Synthesis of the Enantiomer of the Furanocembrane Rubifolide.
J Org Chem
; 62(13): 4313-4320, 1997 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-11671752
13.
Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway.
PLoS One
; 9(5): e96737, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24806487
14.
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.
Cell Rep
; 7(4): 971-81, 2014 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-24813885
15.
Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway.
PLoS One
; 8(8): e69619, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23936340
16.
A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses.
PLoS One
; 7(8): e42386, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22870324
17.
Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases.
J Med Chem
; 51(21): 6631-4, 2008 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18842034
18.
The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors.
Bioorg Med Chem Lett
; 16(8): 2209-12, 2006 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16458510
19.
Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors.
Bioorg Med Chem Lett
; 15(6): 1687-91, 2005 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15745822
20.
Identification of a potent and selective noncovalent cathepsin S inhibitor.
J Pharmacol Exp Ther
; 308(1): 268-76, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-14566006