Detalhe da pesquisa
1.
Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry.
Proc Natl Acad Sci U S A
; 121(22): e2310677121, 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38753503
2.
Affinity selection of double-click triazole libraries for rapid discovery of allosteric modulators for GLP-1 receptor.
Proc Natl Acad Sci U S A
; 120(11): e2220767120, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36893261
3.
Diversity oriented clicking delivers ß-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors.
Proc Natl Acad Sci U S A
; 119(37): e2208540119, 2022 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36070343
4.
Synthesis and structure-activity relationships of aryl fluorosulfate-based inhibitors as novel antitubercular agents.
Bioorg Med Chem Lett
; 98: 129596, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38142914
5.
Identification of simple arylfluorosulfates as potent agents against resistant bacteria.
Proc Natl Acad Sci U S A
; 118(28)2021 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34244433
6.
Chemoenzymatic Tagging of Tn/TF/STF Antigens in Living Systems.
Isr J Chem
; 63(10-11)2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-38737670
7.
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.
Proc Natl Acad Sci U S A
; 116(38): 18808-18814, 2019 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31484779
8.
Sulfur [18F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis.
J Am Chem Soc
; 143(10): 3753-3763, 2021 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33630577
9.
Ligand design for human acetylcholinesterase and nicotinic acetylcholine receptors, extending beyond the conventional and canonical.
J Neurochem
; 158(6): 1217-1222, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33638151
10.
Enhancing Target Tissue Levels and Diminishing Plasma Clearance of Ionizing Zwitterionic Antidotes in Organophosphate Exposures.
J Pharmacol Exp Ther
; 378(3): 315-321, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34145064
11.
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines.
Angew Chem Int Ed Engl
; 60(39): 21195-21199, 2021 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34259368
12.
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry.
J Am Chem Soc
; 142(25): 10899-10904, 2020 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32479075
13.
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs.
Angew Chem Int Ed Engl
; 59(30): 12460-12469, 2020 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32301265
14.
Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.
Toxicol Appl Pharmacol
; 372: 40-46, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30978400
15.
Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase.
Chemistry
; 25(16): 4100-4114, 2019 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30458057
16.
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4 )-Derived Connective Hubs for Bioconjugation to DNA and Proteins.
Angew Chem Int Ed Engl
; 58(24): 8029-8033, 2019 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30998840
17.
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides.
Angew Chem Int Ed Engl
; 58(14): 4552-4556, 2019 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30740848
18.
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization.
J Am Chem Soc
; 140(8): 2919-2925, 2018 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29451783
19.
"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.
J Am Chem Soc
; 140(1): 200-210, 2018 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29265822
20.
Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure.
J Pharmacol Exp Ther
; 367(2): 363-372, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30190337