Lateralization of interaural level differences in children with bilateral cochlear implants.

OBJECTIVES: To investigate the perception of interaural level differences (ILDs) in children with bilateral cochlear implants (BiCIs) and compare them to normal hearing peers. As intracranial shifts in perception of ILDs might have an effect on localization, this was further investigated. METHODS: ILD responses on four different frequency bands (broadband, low-pass, mid-pass and high-pass) were measured in 9 children with BiCIs and 15 children with normal hearing. In the children with BiCIs, 7 of them were implanted sequentially and 2 of them simultaneously. The outcomes were compared with the outcomes from a previous study on advanced localization using the same stimuli as in the current study. The effect of chronological age, inter-implant delay and preoperative residual hearing were also taken into account. RESULTS: No significant differences in ILD responses between children with BiCIs and children with normal hearing were found. For broadband stimuli, children with sequential BiCIs showed a significant shift in their response towards the first implant. A significant correlation was found between inter-implant delay and shift in ILD response for the broadband and high-pass stimuli. The shift in ILD response had no effect on localization. CONCLUSION: Children with BiCIs are able to perceive ILD responses similar to those of normal hearing children. The inter-implant delay has a negative effect on the lateralization of the response towards the first implant side, indicative of deprivation of high-frequency sounds prior to receiving a second implant. This shift, however, is not associated with a shift in localization response.

Benefit of sequential bilateral cochlear implantation in children between 5 to 18 years old: A prospective cohort study.

OBJECTIVE: To determine the benefit of sequential cochlear implantation after a long inter-implantation interval in children with bilateral deafness receiving their second implant between 5 and 18 years of age. STUDY DESIGN: Prospective cohort-study. SETTING: Tertiary multicenter. PATIENTS: 85 children with bilateral deafness and unilateral implantation receiving a contralateral cochlear implant at the age of 5 to 18 years. METHOD: The primary outcomes were speech recognition in quiet and noise (CVC) scores. The secondary outcomes were language outcomes and subjective hearing abilities, all measured before and 12 months after sequential bilateral cochlear implantation. Medians of the paired data were compared using the Wilcoxon signed-rank test. Univariable linear regression analyses was used to analyze associations between variables and performance outcomes. RESULTS: A significant benefit was found for speech recognition in quiet (96% [89-98] vs 91% [85-96]; p < 0.01) and noise (65% [57-75] vs 54% [47-71]; p = 0.01) in the bilateral CI condition compared to unilateral (n = 75, excluded 10 non-users). No benefit was seen for language outcomes. The subjective sound quality score was statistically significant higher in bilateral compared to the unilateral CI condition. Pre-operative residual hearing level in the ear of the second implant, the inter-implant interval and age at time of second implantation was not significantly associated with performance scores. CONCLUSION: After 12 months of use, sequential bilateral cochlear implantation showed improved speech perception in quiet and noise and improved subjective sound quality outcomes in children despite a great inter-implantation interval (median of 8 years [range 1-16 years]).

Crest evolution in newts: implications for reconstruction methods, sexual selection, phenotypic plasticity and the origin of novelties.

The dorsal crest of newts (Salamandridae) is a novel, phenotypically plastic, sexually selected trait that may evolve in association with complex courtship behaviours. We estimated a near-comprehensive, time-calibrated phylogeny for salamandrids and analysed the evolution of their crests and display behaviour. Different models give conflicting reconstructions for crest evolution, showing that likelihood can estimate incorrect ancestral states with strong statistical support. The best-fitting model suggests that crests evolved once and were lost repeatedly, supporting the hypothesis that sexually selected traits may be frequently lost. We demonstrate the correlated evolution of crests and courtship behaviour and show that species with larger numbers of crest-related traits have larger repertoires of behaviours. We also show that phenotypically plastic morphological traits can be maintained over long macroevolutionary timescales (∼25-48 Myr). Finally, we use salamandrids to address how novel structures may arise, and support a model involving the expansion and subdivision of pre-existing structures.