Detalhe da pesquisa
1.
Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.
J Med Chem
; 51(10): 2887-90, 2008 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18433113
2.
Novel 5-HT(1A/1B/1D) receptors antagonists with potent 5-HT reuptake inhibitory activity.
Bioorg Med Chem Lett
; 18(20): 5581-5, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18829312
3.
SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test.
Neuropsychopharmacology
; 32(10): 2163-72, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17356576
4.
Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B.
Psychopharmacology (Berl)
; 192(1): 121-33, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17265079
5.
Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia.
Brain Res
; 1152: 215-27, 2007 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17434465
6.
Characterisation of the selective 5-HT1B receptor antagonist SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): in vivo neurochemical and behavioural evidence of anxiolytic/antidepressant activity.
Neuropharmacology
; 50(8): 975-83, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16581092
7.
SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'methyl-4'-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): a novel, potent and selective 5-HT1B receptor antagonist.
Neuropharmacology
; 50(8): 984-90, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16546225
8.
Effects of the atypical antipsychotics olanzapine and risperidone on plasma prolactin levels in male rats: a comparison with clinical data.
Psychopharmacology (Berl)
; 184(1): 107-14, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16333653
9.
Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone.
Eur J Pharmacol
; 510(1-2): 49-57, 2005 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15740724
10.
Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test.
Brain Res
; 1331: 105-13, 2010 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-20303337
11.
3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors.
Bioorg Med Chem Lett
; 17(4): 1033-6, 2007 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17129726
12.
A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists.
Bioorg Med Chem Lett
; 15(22): 4989-93, 2005 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16168649
13.
3,4-Dihydro-2H-benzoxazinones are 5-HT(1A) receptor antagonists with potent 5-HT reuptake inhibitory activity.
Bioorg Med Chem Lett
; 15(3): 737-41, 2005 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15664848