Detalhe da pesquisa
1.
Chiral Amines via Enantioselective π-Allyliridium-C,O-Benzoate-Catalyzed Allylic Alkylation: Student Training via Industrial-Academic Collaboration.
Acc Chem Res
; 55(15): 2138-2147, 2022 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35830564
2.
Lipid droplets can promote drug accumulation and activation.
Nat Chem Biol
; 16(2): 206-213, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31932720
3.
Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.
PLoS Biol
; 17(10): e3000529, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-31618263
4.
MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.
PLoS Biol
; 17(9): e3000354, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31525186
5.
Enantioselective Iridium-Catalyzed Allylation of Nitroalkanes: Entry to ß-Stereogenic α-Quaternary Primary Amines.
J Am Chem Soc
; 143(25): 9343-9349, 2021 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34152145
6.
Regio- and Enantioselective Iridium-Catalyzed Amination of Racemic Branched Alkyl-Substituted Allylic Acetates with Primary and Secondary Aromatic and Heteroaromatic Amines.
J Am Chem Soc
; 141(1): 671-676, 2019 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30571092
7.
Regio- and Enantioselective Iridium-Catalyzed N-Allylation of Indoles and Related Azoles with Racemic Branched Alkyl-Substituted Allylic Acetates.
Angew Chem Int Ed Engl
; 58(23): 7762-7766, 2019 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30964961
8.
Enantioselective Synthesis of des-Epoxy-Amphidinolide N.
J Am Chem Soc
; 140(49): 17316-17326, 2018 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30457857
9.
Hydroamination versus Allylic Amination in Iridium-Catalyzed Reactions of Allylic Acetates with Amines: 1,3-Aminoalcohols via Ester-Directed Regioselectivity.
J Am Chem Soc
; 140(29): 9087-9090, 2018 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29989803
10.
Amphiphilic π-Allyliridium C,O-Benzoates Enable Regio- and Enantioselective Amination of Branched Allylic Acetates Bearing Linear Alkyl Groups.
J Am Chem Soc
; 140(4): 1275-1279, 2018 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29350523
11.
Lithium Enolates in the Enantioselective Construction of Tetrasubstituted Carbon Centers with Chiral Lithium Amides as Noncovalent Stereodirecting Auxiliaries.
J Am Chem Soc
; 139(1): 527-533, 2017 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27997174
12.
Total Synthesis of (-)-Lasonolide A.
J Am Chem Soc
; 138(36): 11690-701, 2016 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27548113
13.
Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins.
Nat Prod Rep
; 32(3): 411-35, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25338021
14.
A concise synthesis of (-)-lasonolide A.
J Am Chem Soc
; 136(1): 88-91, 2014 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24308383
15.
Enediolate-dilithium amide mixed aggregates in the enantioselective alkylation of arylacetic acids: structural studies and a stereochemical model.
J Am Chem Soc
; 135(45): 16853-64, 2013 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23654300
16.
Stability of cyclic imine toxins: interconversion of pinnatoxin amino ketone and pinnatoxin A in aqueous media.
J Org Chem
; 77(22): 10435-40, 2012 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23116445
17.
Regio- and Enantioselective Iridium-Catalyzed Amination of Alkyl-Substituted Allylic Acetates with Secondary Amines.
Org Lett
; 24(1): 441-445, 2022 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34905364
18.
Kinetic, ESI-CID-MS and Computational Studies of π-Allyliridium C,O-Benzoate-Catalyzed Allylic Amination: Understanding the Effect of Cesium Ion.
ACS Catal
; 12(6): 3660-3668, 2022 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36092640
19.
Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity.
J Med Chem
; 65(24): 16510-16525, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36459397
20.
Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.
J Med Chem
; 65(21): 14721-14739, 2022 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36279149