[Heart preservation by means of hypothermia and hyperbaric oxygenation]. / Konservatsiia serdtsa metodom gipotermii giperbaricheskoi oksigenatsii

The efficiency of the methods of hypothermia and hyperbaric oxygenation for the preservation of canine hearts was studied. The cardiac function was found to reestablish itself nearly completely after 3 hours of preservation, despite some significant metabolic shifts -- disintegration of oxidation and phosphorylation, activation of lysosomal enzymes, reduction of the store of adenyl macroergs and biogenic amines. Five hours of preservation result in irreversible changes in the heart.

[New textile vascular prostheses made of polymer composition materials]. / Novye tekstil'nye sosudistye protezy iz gibridnogo kompozitnogo materiala.

Functional properties of blood vessel prostheses to large degree depend on the longitudinal elasticity of their walls. Theoretical foundations for designing the physico-chemical properties of prostheses walls were worked out, and special methods and measuring apparatuses. New types of vascular textile prostheses make it possible to model biological tissues. The prostheses walls are a composition of polymers of several types of threads differing to large degree in their elasticity. Comparative theoretical and experimental studies on natural blood vessels, blood vessel prostheses (of traditional threads) and new textile prostheses showed that the last mentioned, as far as their elasticity in concerned, are most close to the requirements and that they have good functional properties.

[Approaches to the control of lymphogenic metastatic spread of tumors]. / Puti vozdeistviia na limfogennoe metastazirovanie opukholi.

Lymphopoiesis stimulating drugs were injected into the blood of rabbits bearing Brown-Pearce transplantable tumor. It was found that treatment with mannitol targeted on osmoregulation mechanisms and terrilytin--on blood and lymph coagulation intensified the lymphogenic migration of tumor cells. When used in an experimental series involving endolymphic transplantation of tumor cells, the said drugs promoted tumor cell passage from lymph to blood, which resulted in an increased number of metastasis-bearing animals. It was also found that the promoting effect may be counteracted by preliminary endolymphic injection of a fat-soluble antitumor preparation. Lymphopoiesis and lymph flow stimulation in conjunction with thoracic duct draining may be used for removal of tumor cells from the lymphatics.

[Pharmacokinetic validation of intra-arterial lymphotropic antibiotic therapy of pyo-inflammatory diseases of organs of the peritoneal cavity]. / Farmakokineticheskoe obosnovanie vnutriarterial'noi limfotropnoi antibiotikoterapii gnoino-vospalitel'nykh zabolevanii organov briushnoi polosti.

Intraarterial infusion of antibiotics provided a 1.39-2.84-fold regional increase in the antibiotic concentration as compared to that after the intravenous infusion in the organs and tissues of the abdominal cavity affected by an inflammatory process. Regional intraarterial lymphostimulation provided a 1.31-1.64-fold increase in the antibiotic resorption from the affected organs and tissues of the abdominal cavity to the relevant regional lymph nodes. Combined intraarterial administration of the antibiotic and lymphostimulant made it possible to provide high antibiotic concentrations in both the affected organs and tissues of the abdominal cavity and the respective portions of the regional lymphatic system.

[Accumulation of gentamicin in biological fluids, organs and tissues during regional lymphotropic therapy with antibiotics]. / Nakoplenie gentamitsina v biologicheskikh zhidkostiakh, organakh i tkaniakh pri limfotropnoi regionarnoi antibiotikoterapii.

Gentamicin distribution in biological fluids, organs and tissues, lymph nodes was studied on 70 dogs. Three administration routes were compared: lymphotropic, intramuscular and regional subcutaneous. The lymphotropic route for the drug administration was recommended not long ago. It was shown that the lymphotropic route provided the antibiotic accumulation mainly in some of the abdominal organs as compared to intramuscular administration. Regional lymphotropic administration of the antibiotic to the experimental animals resulted in higher gentamicin levels in the regional lymph nodes and regional organs as compared to the levels observed after the antibiotic regional subcutaneous administration in the same doses.

[Correction of metabolic disorders by magnetic-laser irradiation (experimental study)]. / Korrektsiia metabolicheskikh narushenii magnitolazernym oblucheniem (éksperimental'noe issledovanie).

Five series of experiments were conducted on a model of hepatic insufficiency caused by obstructive jaundice to study the effect of semiconductor infrared laser in a range of 800-900 nm with a static magnetic field on some metabolic changes in the organism. Wistar rats weighing 200-250 g were used. The region of the liver was irradiated through an intact epilated skin. The results provide evidence that a definite role in the pathogenesis of hepatic insufficiency is played by intensification of LPO processes and diminution of antioxidant defence which leads, in turn, to reduction of the insulin-receptor interrelations and sharp decrease of hepatic cell metabolism.

[The effect on the liver of a semiconductor IR laser with a constant magnetic field]. / Izuchenie vliianiia na pechen' poluprovodnikovogo IK-lazera s postoiannym magnitnym polem.

Comparative appraisal of the effect of repeated percutaneous action of semiconductor IR-laser, magnetic field, and a combination of these two factors on the liver showed metabolic changes to be sharply manifest in the first 10 days after exposure to the different variants of action. After 20 irradiation sessions the metabolic changes were less manifest and became stabilized in subsequent irradiation of the animals, which may probably be attributed to certain adaptation of the hepatic tissue to the prolonged effect of the factor. The distinguishing feature of the magnetic-laser effect was an increase of the main substrates of energy metabolism (glucose and lipids) and a stable malonic dialdehyde content with a predominant tendency towards neutralization of free-radical reactions. All this justifies the experimental substantiation of the necessity of using a semiconductor IR-laser with a constant magnetic field for correcting metabolic disorders associated with hepatic insufficiency.

[Potential uses of plasma scalpel in liver and gallbladder surgery]. / Vozmozhnosti plazmennogo skalpelia pri operatsiiakh na pecheni i zhelchnom puzyre.

The article deals with the results of experimental studies and clinical experience in the use of the plasma scalpel in 25 unbred dogs and 192 patients with diseases of the liver and gallbladder. Histological studies of the hepatic tissue after treatment with the laser scalpel allowed the conclusion that such manipulations are safe. The advantages of using the device for arresting bleeding and the flow of bile from the resected hepatic areas were revealed. The accumulated experience in operations on the liver and gallbladder with a plasma scalpel made it possible to develop optimal approaches to the use of the plasma flow in resections of the liver and to suggest three methods for removal of the gallbladder. Their introduction into practice improved the intraoperative possibilities of treatment of the gallbladder bed.

[Magnetic-laser irradiation of the liver in the treatment and prevention of hepatic insufficiency in mechanical jaundice]. / Magnitolazernoe obluchenie pecheni pri lechenii i profilaktike pechenochnoi nedostatochnosti pri mekahnicheskoi zheltukhe.

The effect of magnetolaser irradiation on the liver in obstructive jaundice was studied in experiments on 500 rats. Magnetolaser irradiation was found to have a favourable effect on the functional morphology of the liver; it levels many morphological signs of hepatic insufficiency and thus provides the grounds for carrying out an operation on the bile ducts under optimal conditions. The suggested method of magnetolaser therapy was applied in 142 patients with hepatic insufficiency in obstructive jaundice. The study showed that magnetolaser therapy applied in complex treatment of hepatic insufficiency promotes active restoration of the function of the organ, significantly raises the efficacy of treatment, and reduces the term of the patient's hospital stay.

[Acid-base state disorders and their correction in acute mesenteric vascular obstruction]. / Narusheniia kislotno-shchelochnogo sostoianiia i ikh koreektsiia pri ostroi neprokhodimosti bryzheechnykh sosudov.

The results of the investigation of main indices of acid-base equilibrium in 28 patients with acute obstruction of the mesenteric vessels are set forth. 12 patients out of 28 developed subcompensated or decompensated metabolic acidosis. The authors believe that the correction of acid-base equilibrium disorders is an efficacious factor of intense therapy and recommend to use it at all the stages of the treatment.

[Treatment of experimental pancreonecrosis by occlusion of the pancreatic ducts and cryodestruction of necrotic foci]. / Lechenie éksperimenta'lnogo pancreonekroza okkliuziei pankreaticheskikh protokov i kriodestruktsii ochagov nekroza.

Experimental investigations (experiments in 61 dogs) have shown the application of drug occlusion on the gland duct system with cryodestruction of necrosis foci to be a promising method for treatment of pancreonecrosis.

[Experimental rationale for the use of intra-arterial lymphostimulation in drug treatment of inflammatory diseases of organs of the peritoneal cavity]. / Eksperimental'noe obosnovanie primeneniia vnutriarterial'noi limfostimuliatsii v medikamentoznom lechenii vospalitel'nykh zabolevanii organov briushnoi polosti.

The functional status of regional lymph drainage was studied in 40 rats with various models of pyoinflammatory abdominal diseases. It was shown that intratissue lymphopoiesis and lymph drainage were suppressed in general fecal peritonitis and hemorrhagic pancreonecrosis, which was evident in 1.59-3.15-fold elimination time of the lymphotropic indicator indigo carmine from the tissue and organ depot of the abdomen. The intravenous lymphostimulation with 10% rheomacrodex solution led to 1.06-1.51-fold increases in lymphopoiesis and lymph drainage. Regional intraaortic lymphogenic stimulation caused the most marked changes in the lymph circulatory bed, producing 1.22-1.56-fold effects on lymph drainage of abdominal organs and tissue.

[Use of dibunol and delagil in the treatment of acute pancreatitis]. / Primenenie dibunola i delagila v lechenii ostrogo pankreatita.

The effect of Dibunol and Delagil on the course of experimental pancreatitis was studied in experiments in 80 rats and 36 dogs. The intravenous injection of the drugs was shown to decrease lethality of the animals. Control of biochemical parameters has revealed decreased activity of amylase, lipase, trypsin and malonic dialdehyde, normalized level of superlight luminescence of blood plasma. A good medical effect was obtained in 15 patients with acute pancreatitis.