Detalhe da pesquisa
1.
Towards a platform quantitative systems pharmacology (QSP) model for preclinical to clinical translation of antibody drug conjugates (ADCs).
J Pharmacokinet Pharmacodyn
; 2023 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37787918
2.
Two heads are better than one: current landscape of integrating QSP and machine learning : An ISoP QSP SIG white paper by the working group on the integration of quantitative systems pharmacology and machine learning.
J Pharmacokinet Pharmacodyn
; 49(1): 5-18, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35103884
3.
Expression of tripartite motif-containing protein 28 in primary breast carcinoma predicts metastasis and is involved in the stemness, chemoresistance, and tumor growth.
Tumour Biol
; 39(4): 1010428317695919, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28381187
4.
Detection of high frequency of mutations in a breast and/or ovarian cancer cohort: implications of embracing a multi-gene panel in molecular diagnosis in India.
J Hum Genet
; 61(6): 515-22, 2016 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26911350
5.
Next-generation sequencing-based method shows increased mutation detection sensitivity in an Indian retinoblastoma cohort.
Mol Vis
; 22: 1036-47, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27582626
6.
ATG-101 Is a Tetravalent PD-L1×4-1BB Bispecific Antibody That Stimulates Antitumor Immunity through PD-L1 Blockade and PD-L1-Directed 4-1BB Activation.
Cancer Res
; 84(10): 1680-1698, 2024 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38501978
7.
Quantitative modeling of approved and emerging therapeutics for modifying TTR levels in patients with Transthyretin Amyloid Cardiomyopathy.
CPT Pharmacometrics Syst Pharmacol
; 2023 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37932917
8.
A Quantitative Systems Pharmacology Model Describing the Cellular Kinetic-Pharmacodynamic Relationship for a Live Biotherapeutic Product to Support Microbiome Drug Development.
Clin Pharmacol Ther
; 114(3): 633-643, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37218407
9.
Quantitative modeling predicts competitive advantages of a next generation anti-NKG2A monoclonal antibody over monalizumab for the treatment of cancer.
CPT Pharmacometrics Syst Pharmacol
; 10(3): 220-229, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33501768
10.
Distant Non-Obvious Mutations Influence the Activity of a Hyperthermophilic Pyrococcusfuriosus Phosphoglucose Isomerase.
Biomolecules
; 9(6)2019 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31159273
11.
Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access.
PLoS One
; 13(6): e0198990, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29906280
12.
CorNet: Assigning function to networks of co-evolving residues by automated literature mining.
PLoS One
; 12(5): e0176427, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28545124
13.
Identifying a Clinically Applicable Mutational Burden Threshold as a Potential Biomarker of Response to Immune Checkpoint Therapy in Solid Tumors.
JCO Precis Oncol
; 20172017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29951597
14.
StrandAdvantage test for early-line and advanced-stage treatment decisions in solid tumors.
Cancer Med
; 6(5): 883-901, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28371134
15.
truPK -- human pharmacokinetic models for quantitative ADME prediction.
Expert Opin Drug Metab Toxicol
; 1(3): 555-64, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16863461
16.
Building shared experience to advance practical application of pathway-based toxicology: liver toxicity mode-of-action.
ALTEX
; 31(4): 500-19, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24535319
17.
Identification of a novel glucokinase mutation in an Indian woman with GCK-MODY.
Lancet Diabetes Endocrinol
; 4(4): 302, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-27016322
18.
A systems biology based integrative framework to enhance the predictivity of in vitro methods for drug-induced liver injury.
Expert Opin Drug Saf
; 7(6): 647-62, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18983213