RESUMO
In article is presented, the analysis of the data of the literature and own researches, concerning molecular-genetic mechanisms of antimycobacterial immunity infringements. The role of the factors defining features of a current and an outcome of a tubercular infection, namely of immunity system condition, feature of infecting microbic Mycobacterium tuberculosis strain biological properties (a genotype, a spectrum of drag sensitivity/resistance), influence of combined antitubercular chemotherapy is disc issed. The opinion is expressed that the given factors are necessary for taking into consideration for working out methodology the personalised preventive maintenance and correction of immunity infringements during pulmonary tuberculosis.
Assuntos
Farmacorresistência Bacteriana Múltipla , Imunoterapia , Mycobacterium tuberculosis/efeitos dos fármacos , Tuberculose/imunologia , Tuberculose/terapia , Antituberculosos/uso terapêutico , Citocinas/biossíntese , Citocinas/imunologia , Quimioterapia Combinada , Humanos , Imunidade Celular/genética , Imunidade Celular/imunologia , Interleucina-12/imunologia , Testes de Sensibilidade Microbiana , Mycobacterium tuberculosis/genética , Prognóstico , Células Th1/imunologia , Células Th1/metabolismo , Tuberculose/genética , Tuberculose/microbiologiaRESUMO
Herpesvirus infection is accompanied by imbalance of peripheral mononuclear production of cytokines, by polarizing an immune response by the Th2 pathway. The homozygous TT genotype of T330G polymorphism in the IL-2 gene is an immunogenetic factor that has a protective activity against susceptibility to herpesvirus infection. The risk of progression, the recurrent course of the infection and its poor outcome is positively associated with the heterozygous TG genotype in the IL-2 gene T-330G promoter region and with the homozygous CC type and C allele in the IL-4 gene C-590T promoter region.