Detalhe da pesquisa
1.
EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma.
Nucleic Acids Res
; 50(17): 9814-9837, 2022 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36124657
2.
Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growth.
Proc Natl Acad Sci U S A
; 114(37): 9870-9875, 2017 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28847958
3.
Empowering people to change occupational behaviours to address critical global issues.
Can J Occup Ther
; 82(3): 194-204, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26103717
4.
Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma.
BMC Cancer
; 14: 752, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25300887
5.
The DBD-α4 helix of EWS::FLI is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma.
bioRxiv
; 2024 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-38352344
6.
Lysine specific demethylase 1 is a molecular driver and therapeutic target in sarcoma.
Front Oncol
; 12: 1076581, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36686841
7.
Mitochondrial Dysfunction Is a Driver of SP-2509 Drug Resistance in Ewing Sarcoma.
Mol Cancer Res
; 20(7): 1035-1046, 2022 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35298000
8.
Chromatin profiling reveals relocalization of lysine-specific demethylase 1 by an oncogenic fusion protein.
Epigenetics
; 16(4): 405-424, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32842875
9.
The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma.
Oncogene
; 40(29): 4759-4769, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34145397
10.
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis.
J Vis Exp
; (160)2020 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32658189
11.
Investigating the role of LSD2 as an epigenetic regulator in Ewing sarcoma.
Oncotarget
; 10(39): 3865-3878, 2019 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31231465
12.
Transcriptomic analysis functionally maps the intrinsically disordered domain of EWS/FLI and reveals novel transcriptional dependencies for oncogenesis.
Genes Cancer
; 10(1-2): 21-38, 2019 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-30899417
13.
Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response.
Mol Cancer Ther
; 17(9): 1902-1916, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29997151
14.
Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting.
Oncotarget
; 7(14): 17616-30, 2016 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26848860
15.
Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.
Clin Cancer Res
; 20(17): 4584-97, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24963049
16.
High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors.
J Med Chem
; 56(23): 9496-508, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24237195