1.
Acta Crystallogr Sect E Struct Rep Online
; 65(Pt 2): o360, 2009 Jan 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21581958
RESUMO
In the title compound, 5-(4-chloro-phen-yl)-1-(4-methoxy-phen-yl)-3-(trifluoro-meth-yl)-1H-pyrazole (SC-560), C(17)H(12)ClF(3)N(2)O, a COX-1-selective inhibitor, the dihedral angles between the heterocycle and the chlorobenzene and methoxybenzene rings are 41.66â (6) and 43.08â (7)°, respectively. The dihedral angle between the two phenyl rings is 59.94â (6)°. No classic hydrogen bonds are possible in the crystal, and intermolecular interactions must be mainly of the dispersion type. This information may aid the identification of dosage formulations with improved oral bioavailability.
2.
AAPS PharmSciTech
; 11(2): 485-8, 2010 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20306238