Detalhe da pesquisa
1.
Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy.
Mol Vis
; 30: 74-91, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38601018
2.
Suramin: Effectiveness of analogues reveals structural features that are important for the potent trypanocidal activity of the drug.
Exp Parasitol
; 260: 108744, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38513971
3.
Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue.
Bioorg Med Chem
; 92: 117424, 2023 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37517101
4.
100 years since the publication of the suramin formula.
Parasitol Res
; 123(1): 11, 2023 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38057659
5.
The Extracellular Matrix of Articular Cartilage Controls the Bioavailability of Pericellular Matrix-Bound Growth Factors to Drive Tissue Homeostasis and Repair.
Int J Mol Sci
; 23(11)2022 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35682681
6.
LRP1 Controls TNF Release via the TIMP-3/ADAM17 Axis in Endotoxin-Activated Macrophages.
J Immunol
; 202(5): 1501-1509, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30659107
7.
Heparan Sulfate Proteoglycan Synthesis Is Dysregulated in Human Osteoarthritic Cartilage.
Am J Pathol
; 189(3): 632-647, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30553836
8.
Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3.
Mol Pharmacol
; 92(4): 459-468, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28798097
9.
Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.
J Biol Chem
; 291(42): 22160-22172, 2016 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27582494
10.
Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.
J Biol Chem
; 290(10): 6620-9, 2015 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25564618
11.
Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.
J Biol Chem
; 289(10): 6462-6474, 2014 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24474687
12.
Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1.
J Biol Chem
; 288(1): 332-42, 2013 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23166318
13.
LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage.
FASEB J
; 27(2): 511-21, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23064555
14.
Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes.
Cell Rep
; 43(1): 113668, 2024 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38198277
15.
Proteases involved in cartilage matrix degradation in osteoarthritis.
Biochim Biophys Acta
; 1824(1): 133-45, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21777704
16.
Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex.
Biochem J
; 443(1): 307-15, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22299597
17.
Development of Selective ADAMTS-5 Peptide Substrates to Monitor Proteinase Activity.
J Med Chem
; 66(5): 3522-3539, 2023 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36891740
18.
Identification of membrane proteins regulated by ADAM15 by SUSPECS proteomics.
Front Mol Biosci
; 10: 1162504, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37388246
19.
Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function.
FASEB J
; 25(8): 2770-81, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21518850
20.
Osteoarthritis Pathophysiology: Therapeutic Target Discovery may Require a Multifaceted Approach.
Clin Geriatr Med
; 38(2): 193-219, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35410676