Detalhe da pesquisa
1.
Phase 1, randomized, parallel-group, double-blind, placebo-controlled trial to evaluate the effects of erenumab (AMG 334) and concomitant sumatriptan on blood pressure in healthy volunteers.
Cephalalgia
; 39(1): 100-110, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29783863
2.
Pharmacokinetic-Pharmacodynamic Relationship of Erenumab (AMG 334) and Capsaicin-Induced Dermal Blood Flow in Healthy and Migraine Subjects.
Pharm Res
; 34(9): 1784-1795, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28593473
3.
Translational Pharmacodynamics of Calcitonin Gene-Related Peptide Monoclonal Antibody LY2951742 in a Capsaicin-Induced Dermal Blood Flow Model.
J Pharmacol Exp Ther
; 354(3): 350-7, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26116630
4.
Characterization of the novel GlyT1 PET tracer [18F]MK-6577 in humans.
Synapse
; 69(1): 33-40, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25196464
5.
In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232.
J Pharmacol Exp Ther
; 347(2): 478-86, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23975906
6.
TRPA1 Antagonist LY3526318 Inhibits the Cinnamaldehyde-Evoked Dermal Blood Flow Increase: Translational Proof of Pharmacology.
Clin Pharmacol Ther
; 114(5): 1093-1103, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37562824
7.
First-in-human development of a pharmacodynamic biomarker for PAC1 receptor antagonists using intradermal injections of maxadilan.
Clin Transl Sci
; 15(8): 1968-1977, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35621246
8.
The potent calcitonin gene-related peptide receptor antagonist, telcagepant, does not affect nitroglycerin-induced vasodilation in healthy men.
Br J Clin Pharmacol
; 71(5): 708-17, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21480950
9.
The effects of laropiprant, a selective prostaglandin D2 receptor 1 antagonist, on the antiplatelet activity of clopidogrel or aspirin.
Platelets
; 22(7): 495-503, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21526889
10.
No arguments for increased endothelial nitric oxide synthase activity in migraine based on peripheral biomarkers.
Cephalalgia
; 30(11): 1354-65, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20959430
11.
Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974).
Br J Clin Pharmacol
; 69(1): 15-22, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20078608
12.
Relative Bioavailability of Enalapril Administered as Orodispersible Minitablets in Healthy Adults.
Clin Pharmacol Drug Dev
; 9(2): 203-213, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31411383
13.
Multiple-dose pharmacokinetics, pharmacodynamics, and safety of taranabant, a novel selective cannabinoid-1 receptor inverse agonist, in healthy male volunteers.
J Clin Pharmacol
; 48(6): 734-44, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18508950
14.
Phase I, Randomized, Double-blind, Placebo-controlled, Single-dose, and Multiple-dose Studies of Erenumab in Healthy Subjects and Patients With Migraine.
Clin Pharmacol Ther
; 103(5): 815-825, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28736918
15.
Fatty Acid Amide Hydrolase Inhibition by JNJ-42165279: A Multiple-Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers.
Clin Transl Sci
; 11(4): 397-404, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29575526
16.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the CGRP Binding Monoclonal Antibody LY2951742 (Galcanezumab) in Healthy Volunteers.
Front Pharmacol
; 8: 740, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29089894
17.
What We Observe In Vivo Is Not Always What We See In Vitro: Development and Validation of 11C-JNJ-42491293, A Novel Radioligand for mGluR2.
J Nucl Med
; 58(1): 110-116, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27469358
18.
Clinical study of solid dispersions of itraconazole prepared by hot-stage extrusion.
Eur J Pharm Sci
; 24(2-3): 179-86, 2005 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15661489
19.
(11)C-MK-8278 PET as a tool for pharmacodynamic brain occupancy of histamine 3 receptor inverse agonists.
J Nucl Med
; 55(1): 65-72, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24263088
20.
[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor.
Proc Natl Acad Sci U S A
; 104(23): 9800-5, 2007 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17535893