RESUMO
Clinically (in 186 patients) and experimentally the authors studied the peculiarities of variation in microcirculation, organ blood flow and systemic circulation in acute pancreatitis. The authors emphasize the leading role of early arising circulatory disorders in the pathogenesis of acute pancreatitis. The main pathways for correction of hemodynamic disturbances with due account of their causes, character and the sequence of development are described.
Assuntos
Microcirculação , Pancreatite/fisiopatologia , Doença Aguda , Animais , Capilares/fisiopatologia , Gatos , Cães , Hemodinâmica , Humanos , Hidrocortisona/uso terapêutico , Hipotensão/tratamento farmacológico , Rim/irrigação sanguínea , Fígado/irrigação sanguínea , Circulação Hepática , Pâncreas/irrigação sanguínea , Parassimpatolíticos/uso terapêutico , Prednisolona/uso terapêutico , Simpatomiméticos/uso terapêuticoRESUMO
Microcirculation in the liver was studied in rats and dogs with anaphylactic shock. Injection of a reacting dose of the horse serum led to elevation of systemic arterial pressure by an average of 20 mm Hg; there also occurred spasm of the sinusoids, hepatic venules and an acceleration of blood flow in them With the following blood pressure reduction to 60-40 mm Hg there was blood congestion in the vessels, retarded circulation, intravascular aggregation of the blood formed elements, hemorrhages and ischemic changes. Restoration of systemic arterial pressure and of microcirculation occurred in parallel; no complete normalization of microcirculation in the liver ensued, yet.
Assuntos
Anafilaxia/fisiopatologia , Circulação Hepática , Microcirculação , Animais , Pressão Sanguínea , Cães , Cavalos/imunologia , Soros Imunes , RatosRESUMO
Changes in microcirculation and oxygen pressure in the liver and kidneys were studied in experiments on 42 rats in the course of experimental traumatic shock elicited by Cannon's methoicroscope with a microphoto adapter MFN-12. Oxygen pressure was recorded with the aid of active open hemispheric platinum electrodes with diameters of 150-200 mum. With advencing shock, considerable disturbances of microcirculation and PO2 occurred in hepatic and renal tissues. By the end of the torpid phase of the shock, the PO2 in the liver sank to 1/2.4, and in the kidneys, to less than 1/4 of the respective initial values. The changes in microcirculation were of an ischaemic, vasospastic type in the kidneys, and of a mosaic pattern in the liver: ischaemic segments alternated with areas fully supplied with blood. A severe and rapid course of shock was accompanied by more marked disturbances of PO2 and circulation in hepatic and renal terminal vessels.