Detalhe da pesquisa
1.
Cell membranes and how long drugs may exert beneficial pharmacological activity in vivo.
Br J Clin Pharmacol
; 82(3): 673-82, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27135195
2.
Radioligand binding to intact cells as a tool for extended drug screening in a representative physiological context.
Drug Discov Today Technol
; 17: 28-34, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26724334
3.
Competition in drug binding and the race to equilibrium.
Fundam Clin Pharmacol
; 37(1): 147-157, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-35981720
4.
Conformational constraints in angiotensin IV to probe the role of Tyr², Pro5 and Phe6.
J Pept Sci
; 17(8): 545-53, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21538707
5.
Induced fit versus conformational selection: From rate constants to fluxes and back to rate constants.
Pharmacol Res Perspect
; 9(5): e00847, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34459109
6.
Distinct In Vitro Binding Profile of the Somatostatin Receptor Subtype 2 Antagonist [177Lu]Lu-OPS201 Compared to the Agonist [177Lu]Lu-DOTA-TATE.
Pharmaceuticals (Basel)
; 14(12)2021 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34959665
7.
Involvement of the AT1 receptor subtype in the effects of angiotensin IV and LVV-haemorphin 7 on hippocampal neurotransmitter levels and spatial working memory.
J Neurochem
; 112(5): 1223-34, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20028450
8.
Fluxes for Unraveling Complex Binding Mechanisms.
Trends Pharmacol Sci
; 41(12): 923-932, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33153779
9.
Molecular mechanisms of corticotropin-releasing factor receptor-induced calcium signaling.
Mol Pharmacol
; 75(3): 648-57, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19098121
10.
Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets.
Elife
; 82019 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30605082
11.
Expression, binding, and signaling properties of CRF2(a) receptors endogenously expressed in human retinoblastoma Y79 cells: passage-dependent regulation of functional receptors.
J Neurochem
; 104(4): 926-36, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17976162
12.
Beta-homo-amino acid scan of angiotensin IV.
J Med Chem
; 51(7): 2291-6, 2008 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18386881
13.
Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2.
Bioorg Med Chem
; 16(14): 6924-35, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18556208
14.
Link between a high k on for drug binding and a fast clinical action: to be or not to be?
Medchemcomm
; 9(9): 1426-1438, 2018 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30288218
15.
Slow antagonist dissociation and long-lasting in vivo receptor protection.
Trends Pharmacol Sci
; 27(7): 356-9, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16766051
16.
Kinetic versus allosteric mechanisms to explain insurmountable antagonism and delayed ligand dissociation.
Neurochem Int
; 51(5): 254-60, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17606314
17.
Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat.
Brain Res
; 1131(1): 97-105, 2007 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17169335
18.
Distinct in vivo target occupancy by bivalent- and induced-fit-like binding drugs.
Br J Pharmacol
; 174(23): 4233-4246, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28838028
19.
Angiotensin AT4 receptor ligand interaction with cystinyl aminopeptidase and aminopeptidase N: [125I]Angiotensin IV only binds to the cystinyl aminopeptidase apo-enzyme.
Eur J Pharmacol
; 546(1-3): 19-27, 2006 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16919623
20.
Synergistic inhibition of the enzymatic activity of aminopeptidase N by divalent metal ion chelators.
Fundam Clin Pharmacol
; 20(6): 613-9, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17109655