Detalhe da pesquisa
1.
Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK.
J Pharmacol Exp Ther
; 356(2): 410-23, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26645429
2.
Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.
Bioorg Med Chem Lett
; 25(4): 908-13, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25582600
3.
Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.
Bioorg Med Chem Lett
; 24(17): 4132-40, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25113930
4.
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
J Med Chem
; 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38687966
5.
PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.
Bioorg Med Chem Lett
; 23(7): 1961-6, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23466229
6.
Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.
J Pharmacol Exp Ther
; 341(2): 396-409, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22328573
7.
A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reduction.
J Org Chem
; 76(9): 3484-97, 2011 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21452845
8.
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRß as the Functional Target of Enhancers of Astrocytic apoE.
Cell Chem Biol
; 28(2): 148-157.e7, 2021 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32997975
9.
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Science
; 374(6575): 1586-1593, 2021 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34726479
10.
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate.
J Med Chem
; 61(3): 1001-1018, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29293004
11.
Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.
ACS Med Chem Lett
; 9(2): 68-72, 2018 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456790
12.
The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging.
J Med Chem
; 60(20): 8538-8551, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28957634
13.
Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.
Medchemcomm
; 8(4): 730-743, 2017 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108792
14.
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
J Med Chem
; 60(13): 5673-5698, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28574706
15.
Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.
J Med Chem
; 60(18): 7764-7780, 2017 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28817277
16.
Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery.
ACS Chem Neurosci
; 7(6): 767-75, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26991242
17.
Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability.
J Med Chem
; 59(11): 5284-96, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27228214
18.
Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway.
J Med Chem
; 58(22): 8762-82, 2015 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26207924
19.
Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.
J Med Chem
; 58(1): 419-32, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25353650
20.
Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.
ACS Med Chem Lett
; 6(5): 596-601, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26005540