Detalhe da pesquisa
1.
Assessing trends in cytokine-CYP drug interaction and relevance to drug dosing.
Drug Metab Dispos
; 2024 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38383116
2.
Improved characterization of the pharmacokinetics of acalabrutinib and its pharmacologically active metabolite, ACP-5862, in patients with B-cell malignancies and in healthy subjects using a population pharmacokinetic approach.
Br J Clin Pharmacol
; 88(2): 846-852, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34265100
3.
Acalabrutinib CYP3A-mediated drug-drug interactions: Clinical evaluations and physiologically based pharmacokinetic modelling to inform dose adjustment strategy.
Br J Clin Pharmacol
; 88(8): 3716-3729, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35165925
4.
Clinical evaluation of the potential drug-drug interactions of savolitinib: Interaction with rifampicin, itraconazole, famotidine or midazolam.
Br J Clin Pharmacol
; 88(2): 655-668, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34322894
5.
Exposure-response analysis of acalabrutinib and its active metabolite, ACP-5862, in patients with B-cell malignancies.
Br J Clin Pharmacol
; 88(5): 2284-2296, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34532877
6.
Single-Dose Pharmacokinetics, Excretion, and Metabolism of Zoliflodacin, a Novel Spiropyrimidinetrione Antibiotic, in Healthy Volunteers.
Antimicrob Agents Chemother
; 63(1)2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30373802
7.
Pharmacokinetic Study of Osimertinib in Cancer Patients with Mild or Moderate Hepatic Impairment.
J Pharmacol Exp Ther
; 369(2): 291-299, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30872388
8.
Phase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers.
Br J Cancer
; 118(11): 1425-1433, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29765150
9.
Effect of multiple-dose osimertinib on the pharmacokinetics of simvastatin and rosuvastatin.
Br J Clin Pharmacol
; 84(12): 2877-2888, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30171779
10.
The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib.
Br J Clin Pharmacol
; 84(6): 1156-1169, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29381826
11.
Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach.
Drug Metab Dispos
; 45(1): 35-41, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27777246
12.
Population pharmacokinetics and exposure-response of osimertinib in patients with non-small cell lung cancer.
Br J Clin Pharmacol
; 83(6): 1216-1226, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28009438
13.
Absorption, distribution, metabolism and elimination of 14C-ETX0914, a novel inhibitor of bacterial type-II topoisomerases in rodents.
Xenobiotica
; 47(1): 31-49, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27122100
14.
In vitro and in vivo metabolism of 14C-AZ11, a novel inhibitor of bacterial DNA gyrase/type II topoisomerase.
Xenobiotica
; 45(2): 158-70, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25142218
15.
Assessment of the mass balance recovery and metabolite profile of avibactam in humans and in vitro drug-drug interaction potential.
Drug Metab Dispos
; 42(5): 932-42, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24616266
16.
Longitudinal Circulating Tumor DNA Modeling to Predict Disease Progression in First-Line Mutant Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer.
Clin Pharmacol Ther
; 115(2): 349-360, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38010260
17.
Contribution of artifacts to N-methylated piperazine cyanide adduct formation in vitro from N-alkyl piperazine analogs.
Drug Metab Dispos
; 41(5): 1023-34, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23431111
18.
A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of Savolitinib in Healthy Male Volunteers.
Clin Pharmacol Drug Dev
; 12(4): 424-435, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36808891
19.
Brain exposure of osimertinib in patients with epidermal growth factor receptor mutation non-small cell lung cancer and brain metastases: A positron emission tomography and magnetic resonance imaging study.
Clin Transl Sci
; 16(6): 955-965, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36808835
20.
Evaluation of the Pharmacokinetics and Safety of a Single Dose of Acalabrutinib in Subjects With Hepatic Impairment.
J Clin Pharmacol
; 62(6): 812-822, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34897701