RESUMO
We describe a patient whose primary tumor was a testicular teratocarcinoma predominantly composed of embryonal carcinoma. Before chemotherapy, the retroperitoneal metastases demonstrated heterogeneous, increased glucose metabolism as measured by 2-[18F]fluoro-2-deoxy-D-glucose and PET (FDG-PET). After chemotherapy, FDG uptake was reduced to normal values despite increased tumor volume. Histology revealed a pure mature teratoma. This observation suggests that further studies are needed to determine whether tumor differentiation of testicular teratocarcinoma metastases can be assessed by measuring glucose metabolism.
Assuntos
Carcinoma Embrionário/diagnóstico por imagem , Carcinoma Embrionário/secundário , Desoxiglucose/análogos & derivados , Radioisótopos de Flúor , Neoplasias Retroperitoneais/diagnóstico por imagem , Neoplasias Retroperitoneais/secundário , Neoplasias Testiculares , Tomografia Computadorizada de Emissão/métodos , Adulto , Carcinoma Embrionário/tratamento farmacológico , Carcinoma Embrionário/metabolismo , Desoxiglucose/farmacocinética , Radioisótopos de Flúor/farmacocinética , Fluordesoxiglucose F18 , Humanos , Masculino , Neoplasias Retroperitoneais/tratamento farmacológico , Neoplasias Retroperitoneais/metabolismo , Neoplasias Testiculares/tratamento farmacológico , Neoplasias Testiculares/metabolismoRESUMO
Normally it is difficult and quite frequently impossible to separate physiological aging from its pathophysiological variant. Biochemical, physical and morphological alterations in the arterial wall show a dependence on age. This was the reason for investigating the extent to which the peripheral arterial hemodynamics are changed by age. The parameters, measured by electronic oscillogram, ultrasonic-Doppler-technique and radioangiography, show age dependent alterations. However it must be considered, that peripheral arterial hemodynamics are also influenced by age dependent alterations in cardiac functions.