Detalhe da pesquisa
1.
Incorporation of 53BP1 into phase-separated bodies in cancer cells during aberrant mitosis.
J Cell Sci
; 136(1)2023 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36606487
2.
Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus.
PLoS Comput Biol
; 18(2): e1009855, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35143481
3.
Novel guanidine compounds inhibit platelet-derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proliferation.
Glia
; 69(3): 792-811, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33098183
4.
Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens.
Biochemistry
; 58(9): 1188-1197, 2019 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30714720
5.
The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus.
J Virol
; 91(23)2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28956767
6.
Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis.
Pharmacol Res
; 113(Pt A): 438-448, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27663262
7.
Measuring propargyl-linked drug populations inside bacterial cells, and their interaction with a dihydrofolate reductase target, by Raman microscopy.
Biochemistry
; 54(17): 2719-26, 2015 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25871808
8.
Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus.
J Am Chem Soc
; 137(28): 8983-90, 2015 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26098608
9.
Development of intestinal organoids as tissue surrogates: cell composition and the epigenetic control of differentiation.
Mol Carcinog
; 54(3): 189-202, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24115167
10.
Cyclopropene cycloadditions with annulated furans: total synthesis of (+)- and (-)-frondosin B and (+)-frondosin A.
J Am Chem Soc
; 136(11): 4309-15, 2014 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24575795
11.
Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity.
Antimicrob Agents Chemother
; 58(12): 7484-91, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25288083
12.
Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells.
Bioorg Med Chem
; 22(7): 2188-93, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24613456
13.
Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase.
Biochemistry
; 52(41): 7318-26, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24053334
14.
Z-Phe-Ala-diazomethylketone (PADK) disrupts and remodels early oligomer states of the Alzheimer disease Aß42 protein.
J Biol Chem
; 287(9): 6084-8, 2012 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22253440
15.
Stereodivergent resolution of oxabicyclic ketones: preparation of key intermediates for platensimycin and other natural products.
J Org Chem
; 78(20): 10555-9, 2013 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24047457
16.
Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.
Bioorg Med Chem Lett
; 23(5): 1279-84, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23375226
17.
The tandem ring opening/ring closing metathesis route to oxaspirocycles: an approach to phelligridin G.
Molecules
; 18(2): 2438-48, 2013 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23429417
18.
Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistance.
Antimicrob Agents Chemother
; 56(7): 3556-62, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22491688
19.
Acetylenic linkers in lead compounds: a study of the stability of the propargyl-linked antifolates.
Drug Metab Dispos
; 40(10): 2002-8, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22815313
20.
Viridin analogs derived from steroidal building blocks.
Bioorg Med Chem Lett
; 22(22): 6919-22, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23040731