Detalhe da pesquisa
1.
Multimodal small-molecule screening for human prion protein binders.
J Biol Chem
; 295(39): 13516-13531, 2020 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32723867
2.
A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening.
J Biol Chem
; 291(16): 8541-8, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26872970
3.
Isothermal chemical denaturation to determine binding affinity of small molecules to G-protein coupled receptors.
Anal Biochem
; 473: 41-5, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25481736
4.
Prodrug thiamine analogs as inhibitors of the enzyme transketolase.
Bioorg Med Chem Lett
; 18(2): 505-8, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18083562
5.
Non-charged thiamine analogs as inhibitors of enzyme transketolase.
Bioorg Med Chem Lett
; 18(2): 509-12, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18182286
6.
Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.
Bioorg Med Chem Lett
; 18(6): 2206-10, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18267359
7.
A Guide to Run Affinity Screens Using Differential Scanning Fluorimetry and Surface Plasmon Resonance Assays.
Methods Enzymol
; 610: 135-165, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30390797
8.
Biophysics: for HTS hit validation, chemical lead optimization, and beyond.
Expert Opin Drug Discov
; 12(9): 897-907, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28658992
9.
Large scale meta-analysis of fragment-based screening campaigns: privileged fragments and complementary technologies.
J Biomol Screen
; 20(5): 588-96, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25550355
10.
Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign.
J Biomol Screen
; 20(1): 153-63, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25252731
11.
Isotope effects on the enzymatic and nonenzymatic reactions of chorismate.
J Am Chem Soc
; 127(37): 12957-64, 2005 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16159290
12.
2H, 13C, and 15N kinetic isotope effects on the reaction of the ammonia-rescued K258A mutant of aspartate aminotransferase.
Biochemistry
; 42(27): 8369-76, 2003 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12846586
13.
Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle.
Biochemistry
; 41(8): 2485-91, 2002 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-11851394