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1.
Spectrochim Acta A Mol Biomol Spectrosc ; 271: 120824, 2022 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-35033755

RESUMO

Complex study of quadrupolar azacrown dye (E,E)-5,5́-Bis[2-(4-(4',7',10',13',16'-pentaoxa-1 azacyclooctadecyl)phenyl)ethenyl]-2,2́-bipyridine 1 was performed. Electronic spectra of absorption and fluorescence in different solvents exhibit strong solvatochromism. Electrooptical absorption measurements (EOAM) were performed to determine the electric dipole moments. These measurements gave large values of dipole moments in the ground µg and Franck-Condon excited state µeFC equal to 6.8 ± 0.14C m and 39.3 ± 0.3C m, respectively. Furthermore, the results of EOAM suggest the existence two conformers in the ground state with close energies of electronic transitions. Density functional theory (DFT) calculations directly show that the shape of this molecule is not planar in the ground state and also allows the existence of two stable conformers with close energies. They appeared due to different orientations of the left and right pyridine fragments of the solute. The energies, electric dipole moments and dependences of dipole moments on the strength of applied electric field were calculated for found stable conformers of 1. DFT calculations with TD / B3LYP / 3-21G and cc-pVDZ (Time Depend) approach show that external electric field increases dramatically the dipole moments of the solute under study. The higher field intensity the larger the excited electric dipole in the range intensities from zero to âˆ¼ 2.8·× 10 9 V/m.

2.
Spectrochim Acta A Mol Biomol Spectrosc ; 251: 119395, 2021 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-33440287

RESUMO

Electrooptical absorption measurements (EOAM), solvatochromic dependences and quantum chemical simulations testify to large dipole moments change of two quadrupolar oligophenylenevinylenes upon transition to Franck-Condon excited state µeFC. The values of the dipole moments µg and µeFC are in the range [(4.2 - 4.9)1030] C m and (30.8 - 47.0)1030C m, respectively. The relations of dipole moments in the ground and excited states determined by EOAM correlate well with results obtained via the solvatochromic method. Calculations carried out by density functional theory (DFT) show that optimized configuration of the ground state of these molecules is not planar. The results from all methods applied unequivocally show the structural symmetry breaking in the studied compounds.

3.
Transplant Proc ; 39(9): 2785-7, 2007 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-18021987

RESUMO

UNLABELLED: Biliary complications are known as a weak point of liver transplantation. Their occurrence can be related to the practice of draining the biliary anastomosis performed at the time of transplantation. At our institution, routine of anastomotic biliary drainage was abandoned in June 2004. AIM: We sought to assess the occurrence and character of biliary complications following orthotopic liver transplantation in relation to the technique of anastomosis. MATERIALS AND METHODS: In two groups of transplantees: last 100 transplantations with biliary drainage (48 females and 52 males aged 17 to 64 years) and last 100 transplantations without drainage (52 females and 48 males aged 18 to 67 years). The results of treatment were compared, for biliary complications and their influence on further management. In both groups, the main indications for transplantation were various types of cirrhosis as well as cholestatic diseases. In most cases (167) we performed a cholangiojejunal Roux-en-Y (CBD) end-to-end anastomosis, less commonly (33 cases) hepaticojejunal anastomoses. RESULTS: In the first group, biliary complications (bile leak at the site of drainage, bile leak after T-tube removal, CBD strictures) requiring surgical or endoscopic intervention, occurred in 17% recipients. In one case, the biliary complication resulted in retransplantation. In the second group, biliary complications occurred in 11% patients. None of them caused organ loss. CONCLUSION: Abandoning drainage of the biliary anastomosis has reduced the occurrence of early biliary complications after orthotopic liver transplantation.


Assuntos
Doenças da Vesícula Biliar/epidemiologia , Doenças da Vesícula Biliar/cirurgia , Transplante de Fígado/efeitos adversos , Complicações Pós-Operatórias/epidemiologia , Adulto , Idoso , Ductos Biliares Intra-Hepáticos/patologia , Procedimentos Cirúrgicos do Sistema Biliar , Criança , Feminino , Doenças da Vesícula Biliar/diagnóstico , Humanos , Abscesso Hepático/patologia , Abscesso Hepático/cirurgia , Angiografia por Ressonância Magnética , Pessoa de Meia-Idade , Procedimentos de Cirurgia Plástica , Estudos Retrospectivos
4.
Transplant Proc ; 38(1): 204-8, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16504703

RESUMO

AIM: Placement of a transjugular intrahepatic porta-systemic shunt (TIPS) is a therapeutic option for the management of bleeding esophageal varices. However, the procedure is associated with an increased risk of portal-systemic encephalopathy (PSE). In this study, a two-stage modification of the standard TIPS technique was introduced for the management of variceal bleeding in cirrhotic patients with a high risk of PSE before liver transplantation. METHODS: The modified procedure was applied to four patients with cirrhosis, portal hypertension, and ascites. Two had a history of encephalopathy after variceal bleeding; the other two were encephalopathic at the time of the first stage of the modified procedure. In the first stage, a 6-mm diameter intrahepatic shunt was created using a Palmaz-Schatz stent. One month later, in the second stage, the lumen of the shunt was expanded to a diameter of 10 mm. RESULTS: Both stages of this TIPS procedure were undertaken without any associated adverse events. In particular, neither stage was followed by a deterioration of neurologic status. From completion of the second stage to undertaking orthotopic liver transplantation (a period of 2 to 6 months), no rebleeding from esophageal varices occurred. CONCLUSIONS: A two-stage TIPS procedure to reduce portal hypertension enables a more gradual adaptation to post-TIPS hemodynamic and metabolic changes than occurs after creation of a conventional TIPS. A two-stage TIPS procedure may be the method of choice for treating bleeding from esophageal varices in patients who have a high risk of developing PSE and give them a chance for liver transplantation.


Assuntos
Encefalopatia Hepática/prevenção & controle , Cirrose Hepática/cirurgia , Transplante de Fígado , Derivação Portossistêmica Transjugular Intra-Hepática/métodos , Adulto , Varizes Esofágicas e Gástricas/cirurgia , Feminino , Encefalopatia Hepática/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade
5.
Transplant Proc ; 38(1): 221-5, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16504708

RESUMO

INTRODUCTION: Acute hepatic allograft rejection remains an important problem following liver transplantation. Liver biopsy specimens show a combination of characteristic changes, first observed by Snover as a diagnostic triad: portal inflammation, bile duct damage, and central or portal vein endothelial inflammation (endothelitis or endothelialitis). The aim of this study was to describe our histopathological assessment of liver transplants. MATERIALS AND METHODS: In the period between September 2000 and June 2004, we evaluated 150 liver biopsy specimens from 105 liver recipients. RESULTS: Acute rejection was diagnosed in 26.6% of liver biopsies taken from 31.4% patients who demonstrated clinical symptoms of liver damage. In 90% of cases the rejection was described as minimal or mild, and in 10% as moderate. There was no episode of severe acute rejection. Only four biopsies (10%) showed nothing but Snover triad changes. In 9 (22.5%) cases only acute rejection was diagnosed; the remaining showed in addition to acute rejection the possibility of other concomitant pathologies: viral infection in 15 cases (37.5%), biliary flow obstruction in 11 cases (28.5%), functional cholestasis in two cases (5%), and ischemic complications in three cases (7.5%). CONCLUSIONS: Histologically confirmed acute rejection episodes were diagnosed in 14.9% liver recipients. Liver biopsy specimens, aside from Snover triad features, often showed other unspecific morphological changes. Differentiation of acute rejection from other accompanying diseases is sometimes difficult, requiring precise clinical data and pathologist experience.


Assuntos
Rejeição de Enxerto/patologia , Transplante de Fígado/patologia , Doença Aguda , Adulto , Idoso , Biópsia , Diagnóstico Diferencial , Feminino , Rejeição de Enxerto/diagnóstico , Rejeição de Enxerto/epidemiologia , Humanos , Hepatopatias/classificação , Hepatopatias/cirurgia , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/classificação , Complicações Pós-Operatórias/patologia , Estudos Retrospectivos
6.
Transplant Proc ; 38(1): 226-30, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16504709

RESUMO

INTRODUCTION: Hepatitis C virus (HCV) recurrence is almost universal in patients after liver transplantation. The diagnosis of reinfection is more difficult than that of a primary process, as shown by our pathomorphologic analysis of cases of HCV recurrence. MATERIAL: During 5.5 years, 240 liver biopsies included 54 obtained from liver transplant recipients with primary HCV infections, among whom 26 (56.5%) had clinical signs and symptoms of hepatitis. Nineteen patients from this population underwent 30 liver biopsies. In addition, seven biopsies were performed in five patients without clinical signs of reinfection. RESULTS: In 44.2% of patients with HCV recurrence and 15% without reinfection, the intensity of the primary process in the native livers was assessed as high. Reinfection was found in all patients with liver carcinoma and 67% with hepatocyte dysplasia. Histologic signs of infection were estimated as minimal (n = 4), mild (n = 19), or moderate (n = 4). In five patients with reinfections and one without recurrence, histologic manifestations of acute rejection were also observed. In conclusion, HCV was the indication for liver transplantation in 22.4% cases. Clinical manifestation of recurrence was found in 56.5% of the patients, who tended to be older than those without disease recurrence. Upon microscopy, lobular lesions predominated over the portal changes. Factors predisposing to HCV recurrence were coexistence of other liver disorders, a high intensity of the inflammatory process, hepatocyte dysplasia, and/or hepatocellular carcinoma in the native liver and acute rejection episodes.


Assuntos
Hepatite C/diagnóstico , Hepatite C/cirurgia , Transplante de Fígado/patologia , Adulto , Fatores Etários , Idoso , Biópsia , Feminino , Hepatite C/epidemiologia , Hepatite C/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Reoperação
7.
Transplant Proc ; 38(1): 168-72, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16504694

RESUMO

Posttransplant lymphoproliferative disorder (PTLD) is a well-known complication of both solid organ and bone marrow transplantation. It includes a wide spectrum of proliferative changes ranging from reactive hyperplasia, borderline lesions to malignant lymphomas. PTLD develops in 1% to 10% of transplant recipients. We present 10 cases of PTLD. Five developed after renal, four after liver, and one after heart transplantation. Among the early lesions, we diagnosed two reactive plasmacytic hyperplasias; one infectious mononucleosis-like PTLD; one polymorphic lesion; and one "mixed" case of plasmacytic hyperplasia in one tonsil with a polymorphic PTLD in the second one. Among the lymphomas, we observed three diffuse large B-cell lymphoma (DLBCL); one mantle lymphoma; and one Hodgkin lymphoma-like PTLD. The morphological pictures of six PTLD cases were typical and posed no diagnostic problems. In the one case of plasmacytic hyperplasia, the lymph node morphology was atypical with atrophy of lymphoid components accompanying plasma cell proliferation. Contrary to a good prognosis of early, reactive PTLD, this patient experienced a rapid course and succumbed to sepsis. The most difficult case was a rare Hodgkin lymphoma-like PTLD, which was diagnosed only by a bone marrow biopsy. Because of its noncharacteristic immunophenotype, it was primarily diagnosed as an anaplastic lymphoma of the T-cell type. After additional immunohistochemical studies (BOB and OCT2), we established the final diagnosis of Hodgkin lymphoma-like PTLD. Due to the increasing number of organ transplantations, doctors of various specialties may encounter PTLD.


Assuntos
Transplante de Coração/efeitos adversos , Transplante de Rim/efeitos adversos , Transplante de Fígado/efeitos adversos , Transtornos Linfoproliferativos/diagnóstico , Adulto , Antígenos CD/imunologia , Feminino , Seguimentos , Doença de Hodgkin/diagnóstico , Humanos , Linfoma de Células T/diagnóstico , Transtornos Linfoproliferativos/etiologia , Masculino , Pessoa de Meia-Idade , Prognóstico , Fatores de Tempo
8.
Transplant Proc ; 38(1): 219-20, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16504707

RESUMO

This paper presents the results of liver transplantation for fulminant hepatic failure in 31 patients qualified as UNOS-1 class (extra-urgent indication for transplantation), operated from January 1989 to April 2005. Twenty-one patients (61.8%) survived the 3-month postoperative period. Three-year survival rate with good liver graft function was 52.9% (18 patients). Before the transplantation, eight patients (23.5%) underwent hepatic dialysis using Fractionated Plasma Separation and Adsorption (FPSA) with the use of a Prometheus 4008H System. Liver transplantation remains the only life-saving procedure for the treatment of fulminant liver failure, regardless of its cause.


Assuntos
Falência Hepática Aguda/cirurgia , Transplante de Fígado/métodos , Adulto , Humanos , Transplante de Fígado/mortalidade , Pessoa de Meia-Idade , Análise de Sobrevida , Listas de Espera
9.
Transplant Proc ; 38(1): 244-6, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16504714

RESUMO

INTRODUCTION: Biliary complications are known as the weak point of liver transplantation. Their occurrence can be related to the practice of drainage of the biliary anastomosis, the routine use of which was abandoned in June 2004. The aim of the study was to assess the incidence and type of biliary complications following orthotopic liver transplantation in relation to the technique of biliary anastomosis. MATERIAL AND METHODS: We compared the results of two groups of adult liver transplant recipients: group I, recent 50 transplantations with biliary drainage (25 women: 25 men of age range: 17 to 63 years), and group II, first 50 transplantations without drainage (19 women and 31 men of age range, 20 to 65 years). We examined the problem of biliary complications and their influence on the further management of the patients. In both groups the main indications for transplantation were various types of cirrhosis as well as cholestatic diseases. In the majority of cases (n = 86) an end-to-end common bile duct anastomosis was performed and in 14 cases, hepaticojejunal anastomosis. RESULTS: In group I, biliary complications requiring surgical or endoscopic intervention occurred in 10 (20%) recipients. In one case, biliary complications resulted in the need for retransplantation. In group II, biliary complications occurred in only four (8%) patients, none of which caused organ loss. CONCLUSION: Cessation of biliary anastomosis drainage has reduced the occurrence of early biliary complications following orthotopic liver transplantation.


Assuntos
Sistema Biliar/diagnóstico por imagem , Doenças da Vesícula Biliar/epidemiologia , Vesícula Biliar/cirurgia , Transplante de Fígado/efeitos adversos , Procedimentos de Cirurgia Plástica/métodos , Adolescente , Adulto , Anastomose Cirúrgica/métodos , Ductos Biliares Intra-Hepáticos/diagnóstico por imagem , Colangiografia , Feminino , Doenças da Vesícula Biliar/etiologia , Humanos , Abscesso Hepático/diagnóstico por imagem , Abscesso Hepático/etiologia , Masculino , Pessoa de Meia-Idade
10.
Genetics ; 157(3): 1321-30, 2001 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11238417

RESUMO

The region corresponding to the ABI1-Rps2-Ck1 segment on chromosome 4 of Arabidopsis thaliana was sequenced in Brassica oleracea. Similar to A. thaliana, the B. oleracea homolog BoRps2 is present in single copy. The B. oleracea orthologous segment was located on chromosome 4 and can be distinguished by the presence of an N-myristoyl transferase coding gene (N-myr) between the Rps2 and Ck1 (BoCk1a) genes. The N-myr homologs in Arabidopsis are on chromosomes 2 and 5. Additional homologs for Ck1 are located on these two chromosomes. A second Ck1 homolog found on B. oleracea (BoCk1b) chromosome 7 served to define another orthologous segment located in Arabidopsis chromosome 1. The two segments displayed identical gene content and order in both species, namely BoCK1b, a gene encoding a hypothetical protein (BohypothA) and transcription factor eiF4A. High levels of sequence identity were observed for the coding sequences of all genes examined. Although in general larger spacers were found in Brassica than in A. thaliana, this was not always the case. Promoters were poorly conserved, except for several sequence stretches of a few nucleotides. Comparative sequencing revealed microsyntenic changes resulting from chromosomal structural rearrangements, which are often undetectable by genetic mapping.


Assuntos
Arabidopsis/genética , Brassica/genética , Cromossomos/ultraestrutura , Genoma de Planta , Sequência de Aminoácidos , DNA Intergênico , Éxons , Biblioteca Gênica , Modelos Genéticos , Dados de Sequência Molecular , Mapeamento Físico do Cromossomo , Regiões Promotoras Genéticas , Análise de Sequência de DNA , Homologia de Sequência de Aminoácidos
11.
Neoplasma ; 52(3): 267-72, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-15875091

RESUMO

Histological, clinical and immunohistochemical analysis of 6 cases of primary liver lymphomas (PLL) are presented. PLL represents 4.3% of primary malignant liver tumors diagnosed in our department. The patients were relatively young people, who despite the presence of a large tumor, were in good general health status. There were no signs of scirrhosis, and cancer markers were normal. All lymphomas were CD20, CD79a, BAX positive, CD3, CD30, EMA, CD10, CD5, CD59, c-myc, Bcl2, EBV(LMP), CK negative. The proliferation index (Ki67) was high, ranging from 50-100%. In two cases positive staining for Bcl6 and in another one for cyclin D1 was obtained. The major histological type of the tumor was diffuse large B-cell lymphoma. Positive immunohistochemical results with BAX and the lack of Bcl2, c-myc and CD59 are associated with better prognosis. We have not confirmed the value of Bcl6 and CD10 stains as a predictor of poor outcome. Despite clinically advanced stage at the time of diagnosis, if treated appropriately, the primary lymphoma of the liver has relatively good prognosis (five of our patients are alive).


Assuntos
Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/cirurgia , Linfoma Difuso de Grandes Células B/diagnóstico , Linfoma Difuso de Grandes Células B/cirurgia , Adolescente , Adulto , Idoso , Antineoplásicos/administração & dosagem , Antineoplásicos/uso terapêutico , Antígenos CD59/metabolismo , Terapia Combinada , Intervalo Livre de Doença , Feminino , Humanos , Imuno-Histoquímica , Neoplasias Hepáticas/metabolismo , Linfoma Difuso de Grandes Células B/metabolismo , Masculino , Prognóstico , Proteínas Proto-Oncogênicas c-bcl-2/metabolismo , Proteínas Proto-Oncogênicas c-myc/metabolismo , Transplante de Células-Tronco , Proteína X Associada a bcl-2
12.
Mech Ageing Dev ; 29(2): 111-6, 1985 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-3156264

RESUMO

Rabbits fed a high-cholesterol diet for 3 months showed an increase in peripheral blood lymphocytes with membrane receptors for the Fc portion of immunoglobulin G and a decrease in lymphocytes with receptors for the Fc portion of immunoglobulin M and also with receptors for the third component of the complement. Thus our results indicate changes in lymphocyte membrane receptor expression in experimental hyperlipidemia that may supposedly influence some lymphocyte functions.


Assuntos
Hiperlipidemias/sangue , Fragmentos Fc das Imunoglobulinas/metabolismo , Fragmentos de Imunoglobulinas/metabolismo , Linfócitos/ultraestrutura , Receptores de Complemento/metabolismo , Receptores Fc , Receptores Imunológicos/metabolismo , Animais , Colesterol/análise , Colesterol/sangue , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Eritrócitos/imunologia , Lipoproteínas VLDL/análise , Coelhos , Receptores de IgG , Formação de Roseta , Linfócitos T/imunologia
13.
Mech Ageing Dev ; 40(1): 1-8, 1987 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-3501047

RESUMO

The percentage of cells with high-affinity sheep red blood cell (SRBC) receptors, "active" or "early" rosette-forming cells, (ARFC) in theophylline-resistant peripheral blood T lymphocytes achieve higher values in aged subjects and, in particular, in the group with clinically manifested atherosclerosis. A diminished OKT-4/OKT-8 ratio in theophylline-resistant ARFC was noticed in this group. On the contrary, the proportion of the theophylline-resistant cells with low-affinity receptors, cold or late rosette-forming cells (CRFC) attained lower values in aged subjects than in young subjects. No statistical difference in the proportion of theophylline-sensitive T cells was evident between old and young people, both in ARFC and CRFC fractions. This is indicative of the elevation of activated (or less differentiated) cytotoxic T cells in the peripheral blood of aged subjects with clinically manifested atherosclerosis. The clinical aspect is still to be considered.


Assuntos
Envelhecimento/imunologia , Arteriosclerose/imunologia , Formação de Roseta , Linfócitos T/imunologia , Teofilina/farmacologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Animais , Anticorpos Monoclonais , Antígenos de Superfície/imunologia , Resistência a Medicamentos , Eritrócitos/imunologia , Feminino , Humanos , Ativação Linfocitária , Masculino , Pessoa de Meia-Idade , Ovinos , Linfócitos T/efeitos dos fármacos
14.
Arch Immunol Ther Exp (Warsz) ; 24(3): 359-66, 1976.
Artigo em Inglês | MEDLINE | ID: mdl-60984

RESUMO

An attempt was made to correlate the percentages of macrophages, lymphocytes and granulocytes in the peritoneal effusion in healthy guinea pigs and guinea pigs with experimental allergic encephalomyelitis (EAE), with the macrophage migration inhibition (MMI) test. Varying percentages of the cells had no influence on values of MMI. Similarly, in guinea pigs with EAE, percentages of formed elements in peritoneal effusion were not correlated with intensity of MMI or with histopathologic lesions in the brain and spinal cord. It is suggested that the observed differences are due to individual immunologic responsiveness of animals and, probably, to other hitherto unknown mechanisms.


Assuntos
Encefalomielite Autoimune Experimental/imunologia , Macrófagos/imunologia , Animais , Líquido Ascítico/imunologia , Inibição de Migração Celular , Cobaias , Leucócitos/imunologia , Linfócitos/imunologia , Masculino , Proteína Básica da Mielina/imunologia
15.
Arch Immunol Ther Exp (Warsz) ; 33(6): 837-40, 1985.
Artigo em Inglês | MEDLINE | ID: mdl-2421688

RESUMO

Peripheral blood lymphocytes from young rabbits with experimentally evoked hyperlipidemia and atherosclerosis express enhanced angiogeneic activity. It seems that angiogenesis-enhancing factor in the sera of cholesterol fed rabbits is not present.


Assuntos
Hiperlipidemias/fisiopatologia , Linfócitos/fisiopatologia , Neovascularização Patológica/fisiopatologia , Animais , Arteriosclerose/fisiopatologia , Colesterol na Dieta/administração & dosagem , Hiperlipidemias/etiologia , Transfusão de Linfócitos , Camundongos , Camundongos Endogâmicos BALB C
16.
Arch Immunol Ther Exp (Warsz) ; 39(1-2): 109-15, 1991.
Artigo em Inglês | MEDLINE | ID: mdl-1804039

RESUMO

The influence of vit. E treatment on metabolic and bactericidal granulocyte activity in patients with recurrent infections was studied by chemiluminescence and phagocytosis assays. Vit. E serum level was significantly diminished before therapy. Six weeks supplementation with 200-300 mg/day of vit. E resulted in improvement of clinical status and normalisation of alpha-tocopherol serum level. Bactericidal activity of granulocytes was lower in patients than in the respective controls and it slightly rose after vit. E therapy. Before, therapy, patients granulocytes showed metabolic activity above or within the control range. Vit. E treatment increased, had no effect or decreased granulocyte metabolic activity, but never below the control range.


Assuntos
Infecções Bacterianas/tratamento farmacológico , Granulócitos/efeitos dos fármacos , Vitamina E/farmacologia , Adulto , Idoso , Infecções Bacterianas/etiologia , Infecções Bacterianas/fisiopatologia , Atividade Bactericida do Sangue/efeitos dos fármacos , Feminino , Radicais Livres , Granulócitos/fisiologia , Humanos , Medições Luminescentes , Masculino , Pessoa de Meia-Idade , Oxigênio/metabolismo , Recidiva , Vitamina E/sangue , Deficiência de Vitamina E/complicações , Deficiência de Vitamina E/fisiopatologia
17.
Transplant Proc ; 35(6): 2160-2, 2003 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-14529875

RESUMO

In this case a thyroid gland tumor was diagnosed with fine needle aspiration (FNA) in a 34-year-old female donor of a liver fragment for living related liver transplantation. This diagnosis disqualified her as a donor. The increased incidence of thyroid cancer in Poland presents the possibility of their occurrence in potential donors. Well-differentiated thyroid papillary carcinomas larger than 1 cm in diameter, as well as follicular and medullary carcinomas (regardless their size and or clinical staging), present absolute contraindication to donation. Papillary microcarcinoma restricted to the thyroid gland (with no metastases in local lymph nodes) because of its specific behavior and almost always benign course, requires an individualized approach. It seemed that when a recipient is in a life-threatening condition, we should consider taking organs from a donor suffering of papillary microcarcinoma restricted to the thyroid gland.


Assuntos
Carcinoma Papilar , Transplante de Fígado , Neoplasias da Glândula Tireoide , Doadores de Tecidos/provisão & distribuição , Adulto , Contraindicações , Feminino , Humanos , Seleção de Pacientes
18.
Transplant Proc ; 35(6): 2265-7, 2003 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-14529909

RESUMO

OBJECTIVE: This study assessed the results of liver transplantation in patients with a variety of different indications. METHODS: From 1989 to April 2003, 209 orthotopic liver transplantations (OLTx) were performed on 196 patients, including 178 cases. The diagnoses were: PBC (n = 34); PSC (n = 13); elective postinflammatory cirrhosis in the course of hepatitis C (n = 29); hepatitis B (n = 16); postalcoholic cirrhosis (n = 23), autoimmune cirrhosis (n = 11); Wilson's disease (n = 6); cirrhosis of unknown etiology (n = 10); secondary biliary cirrhosis (n = 5); Budd-Chiari syndrome (n = 6); and benign liver neoplasms (n = 7). RESULTS: The 3-year survival rate in the group of patients transplanted electively was 74.1%. In other groups it was: PBC, 91.4%; PSC, 69.2%; hepatitis C, 69.6%; hepatitis B, 55.5%; postalcoholic cirrhosis, 80%; autoimmune cirrhosis, 81.8%; Wilson's disease, 57.1%; secondary biliary cirrhosis, 40%; Budd-Chiari syndrome, 66.6%; hemochromatosis, 100%; benign neoplasms of the liver, 87.5%; and liver cysts, 100%. CONCLUSIONS: Results of liver transplantation were closely related to the urgency of the procedure. Better results were achieved in patients operated upon routinely compared with in those operated upon emergently (74.1% vs 50%). The best results of liver transplantation were achieved in patients transplanted on a routine basis with a diagnosis of PBC (91.4%), autoimmunologic cirrhosis (81.1%), postalcoholic cirrhosis (80%), or hemochoromatosis (100%). Patients with liver insufficiency due to hepatitis B and Wilson's disease have an increased risk of graft destruction, and the rate of survival in these patients is significantly lower than in other patients.


Assuntos
Hepatopatias/cirurgia , Transplante de Fígado/estatística & dados numéricos , Feminino , Rejeição de Enxerto/tratamento farmacológico , Rejeição de Enxerto/epidemiologia , História do Século XVI , Humanos , Imunossupressores/uso terapêutico , Hepatopatias/classificação , Transplante de Fígado/mortalidade , Masculino , Seleção de Pacientes , Estudos Retrospectivos , Índice de Gravidade de Doença , Taxa de Sobrevida , Fatores de Tempo
19.
Transplant Proc ; 35(6): 2268-70, 2003 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-14529910

RESUMO

The so-called learning factor has been disregarded for many years in analyzing the causes of surgical complications and post-operative mortality; it is also the case for OLT. In our center until April 2003, 209 OLT were performed in 196 patients. We evaluated the impact of experience of the transplantation team on the outcomes of liver transplantation. Thirty-four patients died (mortality rate, 16%) and 1-year survival rate, 64%. Mortality rates varied during different periods of observation due to increasing experience of the transplantation team. The causes of mortality were assessed for a series of 34 patients: it was 75% at the beginning of transplantation procedures while recent deaths have not recently exceeded 10% of cases.


Assuntos
Transplante de Fígado/estatística & dados numéricos , Doenças da Vesícula Biliar/epidemiologia , Humanos , Transplante de Fígado/mortalidade , Complicações Pós-Operatórias/classificação , Complicações Pós-Operatórias/epidemiologia , Estudos Retrospectivos , Taxa de Sobrevida , Resultado do Tratamento
20.
Ann Transplant ; 5(1): 47-9, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-10850612

RESUMO

From 1989 to 1999, 43 orthotopic liver transplantations (OLT) in 40 patients (3 retransplantations) were performed in our Department. The most common indications for OLT were noninflammatory, primary cholestatic liver diseases and postinflammatory liver cirrhosis. Fourty OLT's were done for elective indications, three--on emergency basis, because of fulminant liver failure. The majority of transplantations was performed with classical technique with the excision of retrohepatic vena cava and routine use of the extracorporeal veno-venous bypass. Only in 4 patients the piggyback technique was used and performed without temporary portocaval anastomosis. All 3 patients transplanted for fulminant liver failure died in the perioperative period. Twenty four patients are still alive and well, the longest period of observation exceeding 5 years.


Assuntos
Transplante de Fígado/estatística & dados numéricos , Humanos , Hepatopatias/classificação , Hepatopatias/cirurgia , Transplante de Fígado/métodos , Transplante de Fígado/mortalidade , Transplante de Fígado/fisiologia , Polônia , Reoperação , Estudos Retrospectivos , Taxa de Sobrevida
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