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1.
Phytother Res ; 34(8): 1902-1925, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32147928

RESUMO

Tephrosia purpurea (L.) Pers. is a well-known plant in Ayurveda and named "Sarwa wranvishapaka" for its property to heal wounds. Traditionally, it is practiced for impotency, asthma, dyspepsia, hemorrhoids, syphilis gonorrhea, rheumatism, enlargement of kidney and spleen. It is an important component of herbal preparations like Tephroli and Yakrifti used to cure liver disorders. Various phytocompounds including pongamol, purpurin, purpurenone, tephrosin, bulnesol, tephrostachin, ß-sitosterol, and so on have been reported. Modern pharmacological studies have shown that the plant have wound healing, antileishmanial, anticarcinogenic, antimicrobial, antioxidant, hepatoprotective, antifertility, antispermatogenic, anti-diarrheal, diuretic, and insecticidal properties. Acetylcholinesterase inhibitory action reported from this plant aids its utilization for the development of drugs for Alzheimer's and dementia neurological disorders. Among the known active compounds of T. purpurea, tephrostachin is responsible for antiplasmodial activity, tephrosin, pongaglabol, and semiglabrin exerts antiulcer activity while quercetin, rutin, ß-sitosterol, and lupeol are mainly responsible for its anti-inflammatory and anti-cancer properties. From different toxicological studies, concentrations up to 2,000 mg/kg were considered safe. The present review comprehensively summarizes the ethnomedicine, phytochemistry, pharmacology, and toxicology of T. purpurea. Further research on elucidation of the structure-function relationship among active compounds, understanding of multi-target network pharmacology and clinical applications will intensify its therapeutic potential.


Assuntos
Ayurveda/métodos , Medicina Tradicional/métodos , Plantas/química , Tephrosia/toxicidade , Humanos
2.
Indian J Urol ; 35(2): 129-133, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31000918

RESUMO

INTRODUCTION: In the year 2003, Joshi et al. developed a validated outcome assessment tool to measure the ureteral stent-related symptoms. The original English language Ureteral Stent Symptom Questionnaire (USSQ) has been validated in various languages worldwide. Our objective was to develop the USSQ in Hindi, a commonlyused language in India, by validating it in patients undergoing ureteroscopic lithotripsy. MATERIALS AND METHODS: A final Hindi version of the USSQ was derived from the original English version to apply to the study population by translation, back translation, and face-to-face interviews. The Hindi and English versions were completed by 70 patients undergoing ureteroscopic lithotripsy with stent in situ, on postoperative days 7 and 8, and 4 weeks after stent removal. Similarly, discriminant validity was checked among 50 healthy individuals. A detailed statistical analysis was used to correlate results (Cronbach's α coefficient, Spearman's correlation, and Mann-Whitney U-test). RESULTS: A total of 70 patients were enrolled in the study and 61 completed the final assessment. The median age was 35 years (range: 18-60 years). The USSQ domain scores with the stent in situ were higher than poststent status. The test-retest reliability checked by Cronbach's α coefficient (>0.44) and Spearman's correlation coefficient (>0.44) were acceptable to good. We found high discriminant validity of the questionnaire between patients with stent and the healthy controls (P < 0.05). CONCLUSION: Our results demonstrate satisfactory validity for the Hindi version of the USSQ for the assessment of quality of life in patients with stent. This is ready for application in the clinical studies and the future stent-related research in Hindi language.

3.
Prikl Biokhim Mikrobiol ; 49(6): 592-9, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-25434183

RESUMO

A laccase from the culture filtrate of Phellinus linteus MTCC-1175 has been purified to homogeneity. The method involved concentration of the culture filtrate by ammonium sulphate precipitation and an anion exchange chro- matography on DEAE-cellulose. The SDS-PAGE and native-PAGE gave single protein band indicating that the enzyme preparation was pure. The molecular mass of the enzyme determined from SDS-PAGE analysis was 70 kDa. Using 2,6-dimethoxyphenol, 2,2'[azino-bis-(3-ethylbonzthiazoline-6-sulphonic acid) diammonium salt] (ABTS) and 4-hydroxy-3,5-dimethoxybenzaldehyde azine as the substrates, the Kin, kcat and kt/Km values of the laccase were found to be 160 microM, 6.85 s(-1), 4.28 x 10(4) M(-1) s(-1), 42 microM, 6.85 s(-1), 16.3 x 10(4) M(-1) s(-1) and 92 microM, 6.85 s(-1), 7.44 x 10(4) M(-1) s(-1), respectively. The pH and the temperature optima of the P. linteus MTCC-1175 laccase were 5.0 and 45 degrees C, respectively. The activation energy for thermal denaturation of the enzyme was 38.20 kJ/mole/K. The enzyme was the most stable at pH 5.0 after 1 h reaction. In the presence ofABTS as the mediator, the enzyme transformed toluene, 3-nitrotoluene and 4-chlorotoluene to benzaldehyde, 3-nitroben-zaldehyde and 4-chlorobenzaldehyde, respectively.


Assuntos
Basidiomycota/enzimologia , Benzotiazóis/química , Proteínas Fúngicas , Lacase , Ácidos Sulfônicos/química , Proteínas Fúngicas/química , Proteínas Fúngicas/isolamento & purificação , Proteínas Fúngicas/metabolismo , Lacase/química , Lacase/isolamento & purificação , Lacase/metabolismo , Oxirredução
4.
Plant Biol (Stuttg) ; 24(3): 464-472, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35226384

RESUMO

Seed germination characteristics help predict the degree of invasive success of a species based on capacity of the seeds to germinate and recruit into novel habitats. Hyptis suaveolens (L.) Poit. (Bush mint, Pignut; Lamiaceae) is an invasive plant that is spreading throughout tropical and subtropical regions worldwide. We conducted a study to understand the role of seed size dimorphism in differentiation of germination niche in H. suaveolens. We subjected small and large seeds to varying environmental conditions of temperature (°C), photoperiod (light/dark), salt (NaCl; mM), pH, osmotic potential (MPa), different soil types and ratios (clay:sand) and burial depth (cm). Different germination indices were calculated and their interaction with seed dimorphism studied. There was a significant interaction (P < 0.001) between germination indices and seed dimorphism throughout the treatments. Large seeds had higher germination percentage and rate, indicating higher germination capacity. In addition, these displayed more asynchronous germination under various environments. Small seeds, on the other hand, required a longer germination time as compared to large seeds, indicating slower germination. Differential responses of the two seed morphs to varying environmental conditions, therefore, help H. suaveolens to differentiate its germination niche and establish in heterogeneous environments. These findings will help in devising appropriate management and eradication strategies based on germination ecology of seeds.


Assuntos
Germinação , Hyptis , Sementes/fisiologia , Caracteres Sexuais , Temperatura
5.
J Ethnopharmacol ; 270: 113704, 2021 Apr 24.
Artigo em Inglês | MEDLINE | ID: mdl-33359918

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Withania somnifera, commonly known as Ashwagandha, is an important medicinal herb belonging to family Solanaceae. It is widely used in folkloric and Ayurvedic medicines since antiquity. Traditionally, the plant is highly practiced throughout the globe as immunomodulator, anti-inflammatory, anti-stress, anti-parkinson, anti-alzheimer, cardio protective, neural and physical health enhancer, neurodefensive, anti-diabetic, aphrodisiac, memory boosting etc. The plant is also effective in combating various types of cancer and other related problems of colon, mammary, lung, prostate, skin, blood, liver and kidney. AIM OF THIS REVIEW: The present review represents the critical assessment of the literature available on the anticancerous role of W. somnifera. The present study throws light on its diverse chemical compounds and the possible mechanisms of action involved. This review also suggests further research strategies to harness the therapeutic potential of this plant. MATERIALS AND METHODS: The present review is the outcome of a systematic search of scientific literature about 'Withania somnifera and its role in cancer prevention'. The scientific databases viz. Google Scholar, Science Direct, Pubmed and Web of Science were searched from 2001 to 2019. Textbooks, magazines and newspapers were also consulted. This review summarizes all the published literature about its therapeutic potential for the treatment of different types of cancers. RESULTS: W. somnifera has been widely used in traditional and ayurvedic medicines for treatment of numerous problems related to health and vitality. The plant is a reservoir of diverse phytoconstituents like alkaloids, steroids, flavonoids, phenolics, nitrogen containing compounds and trace elements. Withanolides are the major alkaloids which renders its anticancer potential due to its highly oxygenated nature. The plant is highly effective in combating various types of cancers viz. colon, mammary, lung, prostate, skin, blood, liver and kidney. Previous studies depict that this plant is more effective against breast cancer followed by colon, lung, prostate and blood cancer. Furthermore, from different clinical studies it has been observed that the active constituents of the plant like withaferin-A, withanolide-D have least toxic effects. CONCLUSION: The present review confirms the various medicinal values of W. somnifera without any significant side effects. Withaferin-A (WA) and Withanolides are its most promising anticancer compounds that play a major role in apoptosis induction. Keeping in mind the anticancerous potential of this plant, it is suggested that this plant may further be investigated and more clinical studies can be performed.


Assuntos
Antineoplásicos/farmacologia , Antineoplásicos/uso terapêutico , Neoplasias/tratamento farmacológico , Extratos Vegetais/farmacologia , Extratos Vegetais/uso terapêutico , Withania/química , Animais , Antineoplásicos/efeitos adversos , Antineoplásicos/química , Apoptose/efeitos dos fármacos , Humanos , Ayurveda , Extratos Vegetais/efeitos adversos , Extratos Vegetais/química
6.
J Assoc Physicians India ; 58: 506-8, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-21189701

RESUMO

We report a 30-yr-old lady who was being treated as postpartum psychosis. Patient had generalized tonic clonic convulsions and was found to have bilateral cataract. Her serum calcium, serum magnesium and serum parathyroid were low. On correction of serum magnesium her PTH did not increase. She was hence diagnosed as primary hypoparathyroidism. On correction of her serum calcium her psychosis improved.


Assuntos
Hipoparatireoidismo/complicações , Hipoparatireoidismo/diagnóstico , Período Pós-Parto/psicologia , Transtornos Psicóticos/etiologia , Adulto , Cálcio/sangue , Gluconato de Cálcio/uso terapêutico , Feminino , Humanos , Hipoparatireoidismo/tratamento farmacológico , Injeções Intramusculares , Magnésio/sangue , Sulfato de Magnésio/uso terapêutico , Hormônio Paratireóideo/sangue , Fósforo/sangue , Resultado do Tratamento
7.
Indian J Surg ; 80(3): 281-283, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29973762

RESUMO

Renal LGFMS is an extremely rare tumor. So far, only four cases have been reported in literature. LGFMS are indolent tumor with distinctive histopathological features with potential for late recurrences and metastasis. The diagnosis is made on histopathological examination and supported by immunohistochemical analysis. A 35-year-old young male was presented with flank pain and lump and diagnosed as low-grade fibromyxoid sarcoma after surgery on immunohistochemical analysis. This is the fifth case of renal LGFMS and we presented the review of literature. Radical surgery remains the primary treatment modality. Long follow-up is mandatory.

8.
J Perinatol ; 38(2): 137-141, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29095429

RESUMO

OBJECTIVE: Meconium aspiration syndrome (MAS) is a common cause of neonatal morbidity and mortality. Incomplete understanding of the pathogenesis of MAS has hindered the development of specific therapies. We hypothesized that activation of Toll-like receptors (TLRs) might play a role in the pathogenesis of MAS. The present study evaluated the expression of TLR 1, 4, 7, 8 and 9 in neonates with MAS. STUDY DESIGN: The study included 39 neonates with MAS and 17 healthy gestational age-matched neonates as controls. Neonates with maternal chorioamnionitis, perinatal asphyxia, sepsis and congenital malformations were excluded. Good-quality total RNA from umbilical cord blood was reverse transcribed to prepare cDNA using Bio-Rad reverse transcription kit. This cDNA was used to study the expression status of TLR 1, 4, 7, 8 and 9 by real-time quantitative polymerase chain reaction. RESULTS: Compared with controls, TLR1 and TLR4 were highly expressed, TLR9 was moderately expressed, TLR7 was weakly expressed and TLR8 expression was neutral in neonates with MAS. Within the MAS group, no difference in TLR expression was observed with respect to consistency of meconium, severity of the disease, oxygenation index and outcome. CONCLUSION: There is activation of TLRs in neonates with MAS. We speculate that these TLRs probably act as endogenous ligands for various components of meconium that initiate the inflammatory cascade of MAS and contribute to its pathogenesis.


Assuntos
Inflamação/metabolismo , Síndrome de Aspiração de Mecônio/metabolismo , Receptores Toll-Like/metabolismo , Biomarcadores/sangue , Estudos de Casos e Controles , Feminino , Sangue Fetal , Idade Gestacional , Humanos , Recém-Nascido , Masculino , Síndrome de Aspiração de Mecônio/sangue , Estudos Prospectivos , Transdução de Sinais , Receptores Toll-Like/sangue
9.
J Hazard Mater ; 143(1-2): 150-5, 2007 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-17030427

RESUMO

Breakthrough behaviour of sulphur mustard, the deadliest of persistent chemical warfare agents, on carbon systems such as NaOH/CrO(3)/C, NaOH/CrO(3)/EDA/C and RuCl(3)/C has been studied and the data were compared with that of active carbon. Effects of bed lengths of carbons on breakthrough time have also been correlated. Thereafter, the effects of flow rate of air-sulphur mustard mixture, concentration and temperature on the kinetic parameters such as rate constant (k(v)) and kinetic saturation capacity (W(e)) were analyzed and interpreted by means of modified Wheeler equation. Rate constant was found to be increasing while W(e) was found to be invariable with the increase in air flow rate. Both k(v) and W(e) decreased with the increase of temperature, however, no significant effect on W(e) and k(v) was observed due to concentration change (0.3-0.6 mg/l). The values of kinetic saturation capacity were used to predict the service lives/breakthrough times of carbon beds (when used in filtration systems).


Assuntos
Poluentes Atmosféricos/química , Carbono/química , Gás de Mostarda/química , Compostos de Cromo/química , Etilenodiaminas/química , Compostos de Rutênio/química , Hidróxido de Sódio/química
10.
J Clin Diagn Res ; 11(4): PC01-PC03, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28571203

RESUMO

INTRODUCTION: Access into the collecting system is considered to be the most critical step for Percutaneous Nephrolithotomy (PCNL). AIM: The present study provides a comparative view into antegrade air pyelography and retrograde air pyelography procedures for percutaneous renal access. MATERIALS AND METHODS: A cross-sectional study was conducted on 100 patients with radiopaque renal calculi indicated for PCNL procedure. These patients were randomly assigned to two groups namely antegrade air pyelogram group (Group I) and retrograde air pyelogram group (Group II). In antegrade air pyelogram group, the collecting system was delineated by targeting the renal stone using a 22 gauge spinal needle where the patients were in the prone position. In another group, the collecting system was delineated by retrograde air pyelogram under fluoroscopy guidance. The method of tract dilatation and stone extraction were the same in both groups for comparison of outcome and complication. RESULTS: The mean age of patients was 41.7±13 and 41.4±13.6 years in Group-I and Group-II respectively. The male to female ratio in Groups I and II was 35/15 (70.00%) and 38/12 (76.00%) respectively. In Group-I the average duration of access was 2.66±1.0 minutes after prone positioning whereas it was recorded to be 19.48±5.0 minutes in Group-II, after lithotomy followed by prone positioning of the patient. Duration of radiation exposure was almost similar in both groups. Additional procedural cost was significantly higher in Group II. CONCLUSION: Our study indicated that access for PCNL using antegrade air pyelogram can be a cost-effective and acceptable alternative to retrograde air pyelogram with decreased access time.

11.
Exp Clin Endocrinol Diabetes ; 124(6): 380-4, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27219887

RESUMO

BACKGROUND: Interindividual genetic variations and environmental factors both play pivotal roles in the pathogenesis of metabolic syndrome (MetS). The rationale of this study conducted was to analyze the association of Matrix Metalloproteinase (MMP) gene variants, MMP-1 (-1607 1G/2G) and MMP-2 (-1306 C/T) with susceptibility to MetS and its effect on serum MMP level. METHODS: Study involved 370 subjects with 1:1 distribution of cases and controls. Patients were recruited according to modified NCEP-ATP III criteria for MetS. Clinical, biochemical analysis, PCR-RFLP and ELISA methods were employed for genotyping and estimation of serum MMP level. RESULTS: Significantly (p<0.001) higher Serum MMP-2 (39.13±19.96 ng/ml) was detected in cases as compared to controls. The MMP-2 (-1306 C/T) was significantly associated with the risk of MetS. The variant genotype TT was significantly associated with increased risk of MetS. (p=0.032; OR=2.31; 95%CI=1.07-4.97). No significant association of MMP-1(-1607 1G/2G) was found with risk of MetS. CONCLUSION: Our study concluded that presence of MMP-2 (-1306 C/T) might be associated the risk of MetS. Serum MMP2 level was significantly higher in patients and correlated with clinical parameters of MetS. Clinical implication of the work may help to identify the individuals with high risk of MetS and further complications.


Assuntos
Metaloproteinase 2 da Matriz/sangue , Síndrome Metabólica/sangue , Adulto , Estudos de Casos e Controles , Humanos , Metaloproteinase 1 da Matriz/sangue , Metaloproteinase 1 da Matriz/genética , Metaloproteinase 2 da Matriz/genética , Síndrome Metabólica/genética , Pessoa de Meia-Idade , Risco
12.
ScientificWorldJournal ; 5: 125-7, 2005 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-15702225

RESUMO

Complete avulsion of the ureter is one of the most serious complications of ureteroscopy. It requires open or laparoscopic intervention for repair. This case report emphasizes its management and presents recommendations for prevention in current urological practice.


Assuntos
Ureter/lesões , Ureteroscopia/efeitos adversos , Adulto , Humanos , Masculino , Ureter/cirurgia
13.
Urolithiasis ; 43(2): 171-5, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25344467

RESUMO

INTRODUCTION: Upper urinary tract is accessed for various procedures. The maximum numbers of procedures are carried out in prone position. Perforation of the colon is a well-known complication. The incidence of retrorenal colon varies from 10-20% in prone position, but the chances of injury is around <1%. These facts lead us to review the occurrence of retrorenal colon. The CT scan is imaging test of choice. OBJECTIVE: The aim of this study was to find out the occurrence of retrorenal colon at our centre and potential risk of injury to colon when kidney is punctured at various levels by percutaneous route. MATERIALS AND METHODS: It is a hospital-based descriptive type of observational study. We reviewed CT abdomen in supine and prone position in patients with different problems from January 2013 to December 2013. Inclusion and exclusion criteria applied. Colon posterior to the line as described by Prassopoulos and coworkers is regarded as retrorenal colon and being at risk. RESULTS: A total number of 700 patients were included, 350 each in supine and prone position. Patients had CT scan as a part of workup for pain abdomen in 27% cases, calculus disease in 25% cases, carcinoma bladder in 16% cases and rest were of different diagnoses. Retrorenal colon was found in 2% patients in supine and 6.8% patients in prone position. CONCLUSION: Considering the low incidence, the sample size in our study is small. We recommend multicentric large population-based study to establish the true incidence of retrorenal colon and chances of injury to colon.


Assuntos
Colo/anormalidades , Colo/lesões , Complicações Intraoperatórias/etiologia , Complicações Intraoperatórias/prevenção & controle , Nefropatias/cirurgia , Nefrostomia Percutânea , Posicionamento do Paciente , Adolescente , Adulto , Criança , Pré-Escolar , Anormalidades Congênitas/epidemiologia , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X , Adulto Jovem
14.
Adv Urol ; 2015: 592175, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26788054

RESUMO

Objectives. To evaluate the safety and efficacy of Tadalafil and Tamsulosin in treating Double J stent related symptoms. Methods. In a prospective study, 161 patients with DJ related symptoms were randomized into 3 groups: Group A patients (54), Group B patients (53), and Group C patients (54). They were given Tadalafil, Tamsulosin, and placebo, respectively, at 1st week till removal of DJ stent at 3rd week. All patients completed Ureteral Stent Symptom Questionnaire (USSQ) at 1st week and at 3rd week. The statistical significant difference among groups was determined by the t-test, Kruskal-Wallis test and multivariate analysis were used to assess association of the variables within the three groups, and the level of significance was set at P < 0.05. Results. Tadalafil and Tamsulosin were comparable in relieving urinary symptoms, general health, and work performance (OR = 0.65, 1.8, and 0.92). But Tadalafil was more effective in relieving body pain, sexual problems, and additional problems than Tamsulosin (OR = 5.95, 19.25, and 2.69) and was statistically significant as P < 0.05. Conclusion. Tadalafil was as effective as Tamsulosin in relieving urinary symptom but more effective in relieving sexual symptoms and body pain.

15.
Transplantation ; 65(11): 1433-6, 1998 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-9645798

RESUMO

BACKGROUND: A model of total hepatic ischemia is currently not available in mice. Models described in rats using portosystemic shunts to achieve total ischemia have been notoriously difficult. In mice, the problem is compounded further when using this type of technique because of the small size of the animal. A new technique is described combining partial hepatectomy with clamping of the remnant liver. METHODS: A partial (30%) hepatectomy is performed with resection of the caudate, right lateral, and quadrate lobes, and papillary process. Vascular microclamps are placed across the pedicles of the median and left lateral lobe at the level of the hilum to achieve total ischemia. Spontaneous portocaval shunts through caudate branches and collateral vessels prevent mesenteric congestion. Animals were studied for survival. RESULTS: The procedure consistently took less than 30 min (25+/-2 min), and no bleeding of the resected tissue was observed. Evidence for total hepatic ischemia and spontaneous shunts was demonstrated by the use of an intraportal dye. All animals survived 60 min of ischemia, whereas all died after 90 min of ischemia. CONCLUSION: This is a technically simple and rapid procedure to perform. In the current environment of multiple knockout mice and bioreagents that are available, a model of this type is essential.


Assuntos
Isquemia , Circulação Hepática/fisiologia , Animais , Constrição , Modelos Animais de Doenças , Hepatectomia/métodos , Isquemia/etiologia , Isquemia/patologia , Isquemia/fisiopatologia , Fígado/patologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL
16.
Am J Cardiol ; 81(11): 1315-7, 1998 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-9631969

RESUMO

Significant carotid stenosis in the presence of an occluded contralateral artery has a poor prognosis with medical therapy alone. Carotid cross clamping during surgical endarterectomy results in critical flow reductions in patients with inadequate collateral flow, and represents a significant risk for procedural strokes. Carotid stenting is being evaluated as an alternative to endarterectomy. We describe the immediate and late outcome of a series of 26 patients treated with carotid stenting in the presence of contralateral carotid occlusion. The mean age of the patients in this group was 65 +/- 9 years, 23 (89%) were men and 10 (39%) were symptomatic from the vessel treated. The procedural success of carotid stenting in this group of patients was 96%. The mean diameter stenosis was reduced from 76 +/- 15% to 2.8 +/- 5%. There was 1 (3.8%) minor stroke in a patient who developed air embolism during baseline angiography. At late follow-up there was no neurologic event in any patient at a mean of 16 +/- 9.5 months after the procedure. Thus, carotid stenting of lesions with contralateral occlusion can be performed successfully with a low incidence of procedural neurologic complications and late stroke.


Assuntos
Isquemia Encefálica/terapia , Estenose das Carótidas/terapia , Stents , Idoso , Isquemia Encefálica/diagnóstico , Estenose das Carótidas/diagnóstico , Transtornos Cerebrovasculares/etiologia , Diagnóstico por Imagem , Feminino , Seguimentos , Humanos , Processamento de Imagem Assistida por Computador , Masculino , Pessoa de Meia-Idade , Exame Neurológico , Fatores de Risco , Resultado do Tratamento
18.
J Bone Joint Surg Am ; 72(4): 486-94, 1990 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-2324134

RESUMO

Fifty-two patients who had a tumor in the lower extremity (thirty-seven, a giant-cell tumor and fifteen, a small osteosarcoma that had not metastasized) had dual-fibular strut-grafting to bridge the osseous gap resulting from excision of the tumor. The size of the gap ranged from nine to twenty-four centimeters. The average time until union ranged from ten to twenty months. The ipsilateral fibula was used in thirty-six patients and both fibulae, in the remaining sixteen patients. Immediate reimplantation and adequate fixation of the fibular graft to the proximal and distal ends of the bone to be grafted, along with placement of a cuff of cancellous bone at the host-graft junction and between the fibular struts, fostered early union of the graft to the host bone. Insertion of Kirschner wires inside these long grafts helped to maintain continuity of the graft when a stress fracture occurred. Eight patients who had a non-union at one of the host-graft sites and three who had a stress fracture had subsequent cancellous bone-grafting to obtain union. Superficial infection was the most common complication and was seen in seventeen patients.


Assuntos
Neoplasias Ósseas/cirurgia , Transplante Ósseo/métodos , Fíbula/cirurgia , Tíbia/cirurgia , Adolescente , Adulto , Neoplasias Ósseas/diagnóstico por imagem , Fios Ortopédicos , Criança , Feminino , Fíbula/diagnóstico por imagem , Fíbula/transplante , Tumores de Células Gigantes/diagnóstico por imagem , Tumores de Células Gigantes/cirurgia , Sobrevivência de Enxerto , Humanos , Masculino , Pessoa de Meia-Idade , Osteossarcoma/diagnóstico por imagem , Osteossarcoma/cirurgia , Complicações Pós-Operatórias , Radiografia , Tíbia/diagnóstico por imagem
19.
Lepr Rev ; 62(2): 158-70, 1991 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-1870378

RESUMO

A total of 128 leprosy patients were investigated for the morphological type of anaemia, the underlying disturbances in iron metabolism and patterns of erythropoiesis and other cytomorphological changes in the bone marrow. The anaemia was a mild to moderate degree in paucibacillary (PB) leprosy, while in multibacillary (MB) leprosy it was of a severe degree. Iron deficiency was observed in only a few patients. Impaired iron utilization as observed in a anaemia of a chronic disorder was a common finding in MB leprosy (41.7%) and more so in new cases (50%). Megaloblastic erythropoiesis was also more frequent in MB leprosy (45.2%) as compared to PB leprosy (16%), accounting for the severe degree of anaemia in the former type. In 17.2% of the total patients (MB, 21.4%; PB, 9%) both megaloblastic erythropoiesis and features of impaired iron utilization were observed in bone marrow. Disturbances in iron metabolism and erythropoiesis were also observed but to a lesser degree in patients receiving specific antileprosy treatment. Irrespective of the type of disease and duration of treatment, increasing frequency of acid-fast bacillia (AFB) positivity and granulomas was observed in the bone marrow with an increasing severity of anaemia.


Assuntos
Anemia/sangue , Medula Óssea/patologia , Eritropoese/fisiologia , Hanseníase/sangue , Anemia/etiologia , Anemia/patologia , Hemólise , Humanos , Hanseníase/complicações , Hanseníase/patologia , Hanseníase/fisiopatologia
20.
J Bone Joint Surg Br ; 75(6): 962-6, 1993 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-8245092

RESUMO

We treated 25 patients with severely deformed and shortened lower limbs by double oblique diaphyseal osteotomy of the short deformed bone, followed by balanced skeletal traction to correct the alignment and increase the length of the limb. The technique is simple and inexpensive and does not require special equipment. It has the advantage of allowing rapid lengthening and secure healing as the overlap allows end-to-end union with no bone gap. The lengthening achieved ranged from 6 to 16 cm. No serious complications were encountered.


Assuntos
Alongamento Ósseo/métodos , Desigualdade de Membros Inferiores/cirurgia , Osteomielite/complicações , Osteotomia/métodos , Tração/métodos , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Desigualdade de Membros Inferiores/diagnóstico por imagem , Desigualdade de Membros Inferiores/etiologia , Desigualdade de Membros Inferiores/patologia , Masculino , Radiografia
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