1.
Org Biomol Chem
; 21(38): 7712-7716, 2023 Oct 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37702379
RESUMO
We developed a phosphine-catalyzed ring-opening reaction of cyclopropenones with dicarbonyl compounds as C-nucleophiles, leading to 1,3,3'-tricarbonyl compounds. During this neutral procedure, C-acylation is more dominant than O-acylation. This transition-metal free procedure features mild and neutral reaction conditions with good atom economy. As such, it represents a facile pathway to access 1,3,3'-tricarbonyl derivatives.