Detalhe da pesquisa
1.
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Cell
; 172(1-2): 55-67.e15, 2018 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29307491
2.
Structure-based design of bitopic ligands for the µ-opioid receptor.
Nature
; 613(7945): 767-774, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36450356
3.
Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists.
EMBO J
; 42(11): e112940, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37038975
4.
Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature
; 560(7720): 666-670, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30135577
5.
Structural Characterization of KOR Inactive and Active States for 3D Pharmacology and Drug Discovery.
Handb Exp Pharmacol
; 271: 41-64, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-33945028
6.
Harnessing Ion-Binding Sites for GPCR Pharmacology.
Pharmacol Rev
; 71(4): 571-595, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31551350
7.
Binding mode analyses of NAP derivatives as mu opioid receptor selective ligands through docking studies and molecular dynamics simulation.
Bioorg Med Chem
; 25(8): 2463-2471, 2017 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28302509
8.
Exploration on natural product anibamine side chain modification toward development of novel CCR5 antagonists and potential anti-prostate cancer agents.
Bioorg Med Chem Lett
; 25(17): 3721-5, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26096680
9.
Small molecule inhibits activity of scavenger receptor A: Lead identification and preliminary studies.
Bioorg Med Chem Lett
; 25(16): 3179-83, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26094120
10.
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14ß-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.
Bioorg Med Chem
; 23(8): 1701-15, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25783191
11.
Synthesis and Characterization of 5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC) and Its Analogues as Non-nitrogenous 5-HT2B Ligands.
J Nat Prod
; 78(8): 1859-67, 2015 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26270954
12.
5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
Bioorg Med Chem Lett
; 24(6): 1489-92, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24582985
13.
Binding mode characterization of 6α- and 6ß-N-heterocyclic substituted naltrexamine derivatives via docking in opioid receptor crystal structures and site-directed mutagenesis studies: application of the 'message-address' concept in development of mu opioid receptor selective antagonists.
Bioorg Med Chem
; 21(21): 6405-13, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24055076
14.
Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and µ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics.
J Med Chem
; 66(15): 10304-10341, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37467430
15.
Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D2 or D3 Receptor Agonists.
J Med Chem
; 64(21): 16088-16105, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34699207
16.
Ligand-Dependent Effects of Methionine-8 Oxidation in Parathyroid Hormone Peptide Analogues.
Endocrinology
; 162(2)2021 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33242090
17.
Novel Dual-Target µ-Opioid Receptor and Dopamine D3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management.
J Med Chem
; 64(11): 7778-7808, 2021 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34011153
18.
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.
Elife
; 102021 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33555255
19.
Intracellular Transfer of Na+ in an Active-State G-Protein-Coupled Receptor.
Structure
; 26(1): 171-180.e2, 2018 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29249607
20.
Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells.
Elife
; 62017 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28771403