Evaluating the effect of nipple stimulation during labour on labour progression in term pregnant women.

This study aimed to assess the effect of nipple stimulation during labour on duration of latent and active phases of labour in the term pregnant women. Pregnant women (222) were divided into two groups of nipple stimulation and control. Duration of latent and active phases of labour, the number of women treated with oxytocin, rate of caesarean section (C-section) and foetal outcomes were compared. The median of the latent phase duration of labour in the intervention and control groups was 3.2 (1.3-6.3) and 4.8 (0.8-3.0) h, respectively (p = .008); however, the median of active phase duration was 2.3 (1.4-3.0) in the intervention group and 2.5 (2.0-3.3) in control group, which was not significantly different (p = .249). Additionally, the number of women treated with oxytocin in nipple stimulation group was significantly (p = .001) less than the control group. More studies are needed to evaluate optimum frequency and duration of nipple stimulation during labour.IMPACT STATEMENTWhat is already known on this subject? In limited studies, nipple stimulation is considered as a low-complication method for stimulating labour at onset.What do the results of this study add? Nipple stimulation can be applied during labour for accelerating latent phase and reducing oxytocin infusion.What are the implications of these findings for clinical practice and/or further research? Nipple stimulation can be applied as a non-pharmacological and non-invasive method allowing patient to control her own labour progression more effectively.

Dysregulated miRNAs in recurrent miscarriage: A systematic review.

Recurrent miscarriage (RM) is a complex reproductive medicine disease that affects many families. The cause of RM is unclear at this time; however, lifestyle and genetic variables may influence the process. The slight alteration in miRNA expression has enormous consequences for a variety of difficulties, one of which may be RM. The target of this systematic study was to provide a framework of the dysregulated miRNAs in RM. The Prisma guidelines were applied to perform current systematic review pertaining to articles in the seven databases. Thirty-nine papers out of 245 received fulfilled all inclusion requirements. From all the mentioned miRNAs, 40 were up-regulated (65.57 %), whereas 21 were down-regulated (34.43 %). These dysregulated miRNAs contributed to the pathophysiology of RM by influencing key pathways and processes such as apoptosis, angiogenesis, epithelial-mesenchymal transition, and the immune system. Understanding the dysregulation of miRNAs, as well as the pathways and processes that engage these miRNAs and impact disease pathogenesis, may aid in clarifying the unknown underlying mechanisms of RM and the development of novel molecular therapeutic targets and medical domains.