Detalhe da pesquisa
1.
Modular preparation of biphenyl triazoles via click chemistry as non-competitive hyaluronidase inhibitors.
Bioorg Chem
; 146: 107291, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38521011
2.
Molecular dynamics simulations reveal the inhibition mechanism of Cdc42 by RhoGDI1.
J Comput Aided Mol Des
; 37(7): 301-312, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37286854
3.
Advances in the development of Rho GTPase inhibitors.
Bioorg Med Chem
; 90: 117337, 2023 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37253305
4.
Validation of catalytic site residues of Ubiquitin Specific Protease 2 (USP2) by molecular dynamic simulation and novel kinetics assay for rational drug design.
Mol Divers
; 27(3): 1323-1332, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35932436
5.
Molecular dynamics simulations reveal the activation mechanism of mutations G12V and Q61L of Cdc42.
Proteins
; 90(7): 1376-1389, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35152498
6.
Prospect of Anterior Gradient 2 homodimer inhibition via repurposing FDA-approved drugs using structure-based virtual screening.
Mol Divers
; 26(3): 1399-1409, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-34181147
7.
Activation Mechanism of RhoA Caused by Constitutively Activating Mutations G14V and Q63L.
Int J Mol Sci
; 23(24)2022 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36555100
8.
Tetraethylthiuram disulphide alleviates pulmonary fibrosis through modulating transforming growth factor-ß signalling.
Pharmacol Res
; 174: 105923, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34607006
9.
Lycorine ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3 inflammasome activation and pyroptosis.
Pharmacol Res
; 158: 104884, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32428667
10.
Dissociation mechanism of GDP from Cdc42 via DOCK9 revealed by molecular dynamics simulations.
Proteins
; 87(6): 433-442, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30714195
11.
Development and evaluation of a highly reliable assay for SUMO-specific protease inhibitors.
Bioorg Med Chem Lett
; 26(9): 2124-8, 2016 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27032332
12.
Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility.
Proc Natl Acad Sci U S A
; 110(4): 1261-6, 2013 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23284167
13.
Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells.
Nat Chem Biol
; 8(5): 486-93, 2012 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22484541
14.
In silico discovery of aminoacyl-tRNA synthetase inhibitors.
Int J Mol Sci
; 15(1): 1358-73, 2014 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24447926
15.
Engineered assemblies from isomeric pentapeptides augment dry eye treatment.
J Control Release
; 365: 521-529, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38040342
16.
Discovery of N-(4-sulfamoylphenyl)thioureas as Trypanosoma brucei leucyl-tRNA synthetase inhibitors.
Org Biomol Chem
; 11(32): 5310-24, 2013 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23842857
17.
The structural and bonding evolution in cysteine-gold cluster complexes.
Phys Chem Chem Phys
; 15(5): 1690-8, 2013 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23247849
18.
ASD: a comprehensive database of allosteric proteins and modulators.
Nucleic Acids Res
; 39(Database issue): D663-9, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21051350
19.
Identification of Trypanosoma brucei leucyl-tRNA synthetase inhibitors by pharmacophore- and docking-based virtual screening and synthesis.
Bioorg Med Chem
; 20(3): 1240-50, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22249121
20.
Discovery of oridonin as a novel agonist for BRS-3.
Phytomedicine
; 100: 154085, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35405616