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1.
Small ; : e2403881, 2024 Jul 14.
Artigo em Inglês | MEDLINE | ID: mdl-39004854

RESUMO

Orbital angular momentum flow can be used to develop a low-dissipation electronic information device by manipulating the orbital current. However, efficiently generating and fully harnessing orbital currents is a formidable challenge. In this study, an approach is presented that induces a colossal orbital current by gradient oxidation in Pt/Ta to enhance spin-orbit torque (SOT) and achieve high-efficiency magnetization switching. The maximum efficiency of the SOT before and after the gradient oxidation of Ta is improved relative to that of Pt by ≈600 and 1200%, respectively. The large SOT originates from the colossal orbital current because of the orbital Rashba-Edelstein effect induced by the gradient oxidation of Ta. In addition, a large spin-to-charge conversion efficiency is observed in yttrium iron garnet/Pt/TaOx because of the inverse orbital Rashba-Edelstein effect. Harnessing the orbital current can help effectively minimize the critical current density of the current-induced magnetization switching to 2.26-1.08 × 106 A cm-2, marking a 12-fold reduction compared to that using Pt. This findings provide a new path for research on low-dissipation spin-orbit devices and improve the tunability of orbital current generation.

2.
Opt Express ; 31(5): 8453-8464, 2023 Feb 27.
Artigo em Inglês | MEDLINE | ID: mdl-36859960

RESUMO

Large-scale, and high-throughput produced devices with strong ultrabroadband absorption and high angular tolerance are in demand for applications such as thermal imaging, energy harvesting, and radiative cooling. Despite long-standing efforts in design and fabrication, it has been challenging to achieve all these desired properties simultaneously. Here, we create a metamaterial-based infrared absorber fabricated from thin films of epsilon-near-zero (ENZ) materials grown on metal-coated patterned silicon substrates that exhibit ultrabroadband infrared absorption in both p- and s-polarization at angles ranging from 0° to 40°. The results show that the structured multilayered ENZ films exhibit high absorption (> 0.9) covering the entire 8∼14 µm wavelengths. In addition, the structured surface can be realized via scalable, low-cost methods on large-area substrates. Overcoming the limitations on angular and polarized response improves performance for applications such as thermal camouflage, radiative cooling for solar cell, thermal image and et., al.

3.
Opt Express ; 31(24): 39557-39567, 2023 Nov 20.
Artigo em Inglês | MEDLINE | ID: mdl-38041274

RESUMO

We proposed and demonstrated a metasurface based terahertz polarizer consisting of an optically responsive nanocomposite and a flexible base body, which fulfilled the function of linear-to-circular polarization conversion in transmission mode. Meanwhile, as the dynamic and stretchable materials enable the active manipulation of conversion points, evident frequency shifts for circular polarization transformation were discovered by applying laser irradiation and tension. Hence the modulation of conversion points covered a broadband with combination of those two external excitations. This THz polarization convertor may find its applications in polarization controls and beam steering, which also provides a low-cost and large-scale manufacturable method to achieve versatile active THz devices.

4.
Molecules ; 28(3)2023 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-36770860

RESUMO

Sodium (S)-2-(dithiocarboxylato((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)-4(methylthio)butanoate (GMDTC) is the first compound to use cadmium repellent as an indication. In this paper, we established and validated a bioanalytical method for the determination of GMDTC in rat plasma, and used it to determine the drug concentrations in the plasma of rats after intravenous dosing in different genders and dosages. After pretreating the plasma samples with an acetonitrile-water-ammonia solution (70:30:1.25, v/v/v), liquid chromatographic separations were efficiently achieved with a XBridge C18 column using a 5 min gradient system of aqueous ammonium bicarbonate and 95% acetonitrile-water solution (95:5, v/v) as the eluent. The GMDTC and metolazone (internal standard, IS) detection were carried out using high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (LC-MS/MS), monitored at m/z 390.06-324.1 (for the GMDTC, tR: 2.03 min) and m/z 366.0-259.2 (for IS, tR: 3.88 min). The GMDTC was stable under various testing conditions, and this analytical method conforms to the verification standard of biological analysis methods. The half-life (t1/2) was determined to be 0.54-0.65 h for the intravenous, mean distribution volume and clearances were 1.08-2.08 L/kg and 1-3 L/h/kg, respectively. The AUC0-t and AUC0-∞ found after increasing the dosage exhibited a linear relationship with the administered dose. There were no statistically significant differences in the values obtained for the different genders at dosages of 50, 100 and 250 mg/kg, respectively (p > 0.05). This is the first report of a bioanalytical method to quantify GMDTC in rat plasma using LC-MS/MS, which provides useful information for the study of its pharmacological effects and clinical applications.


Assuntos
Cádmio , Espectrometria de Massas em Tandem , Ratos , Feminino , Masculino , Animais , Cromatografia Líquida/métodos , Espectrometria de Massas em Tandem/métodos , Cromatografia Líquida de Alta Pressão , Indicadores e Reagentes , Reprodutibilidade dos Testes
5.
Opt Express ; 30(3): 3645-3653, 2022 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-35209618

RESUMO

Metamaterials have shown great potential for modulation on the amplitude, phase and polarization of the terahertz wave. Here vacancies were introduced into the metamaterial arrays to tune the mutual interaction between the constituent resonators, which could heavily affect the electromagnetic response of the whole metamaterial arrays. We show that the introduced vacancies in the metamaterial arrays can effectively affect the resonance mode of the metamaterial arrays. Based upon the vacancy mediated coupling, a silicon-metal hybrid metamaterial arrays were designed to achieve active modulation of propagating terahertz waves.

6.
Opt Express ; 30(16): 29379-29387, 2022 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-36299113

RESUMO

Two terahertz metamaterials were joined by a conductivity variable VO2 patch to obtain a metamaterial dimer. By applying voltage or heat to the VO2 patches, active modulation of terahertz wave could be achieved. A cut-wire metamaterial was placed adjacent to the VO2 joined dimer to affect its electromagnetic response. It was found that the cut wire could heavily impact the resonance mode of the VO2 joined dimer, which gives dual resonance dips in transmission spectrum for both insulating and conducting states of VO2 patches. As a result, by tuning the conductivity of VO2, active dual band phase modulation could be achieved with high transmission window by this dimer-cut wire coupling system.

7.
J Nanobiotechnology ; 19(1): 437, 2021 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-34930304

RESUMO

BACKGROUND: Exosomes secreted from stem cells exerted salutary effects on the fibrotic liver. Herein, the roles of exosomes derived from human embryonic stem cell (hESC) in anti-fibrosis were extensively investigated. Compared with two-dimensional (2D) culture, the clinical and biological relevance of three-dimensional (3D) cell spheroids were greater because of their higher regeneration potential since they behave more like cells in vivo. In our study, exosomes derived from 3D human embryonic stem cells (hESC) spheroids and the monolayer (2D) hESCs were collected and compared the therapeutic potential for fibrotic liver in vitro and in vivo. RESULTS: In vitro, PKH26 labeled-hESC-Exosomes were shown to be internalized and integrated into TGFß-activated-LX2 cells, and reduced the expression of profibrogenic markers, thereby regulating cellular phenotypes. TPEF imaging indicated that PKH26-labeled-3D-hESC-Exsomes possessed an enhanced capacity to accumulate in the livers and exhibited more dramatic therapeutic potential in the injured livers of fibrosis mouse model. 3D-hESC-Exosomes decreased profibrogenic markers and liver injury markers, and improved the level of liver functioning proteins, eventually restoring liver function of fibrosis mice. miRNA array revealed a significant enrichment of miR-6766-3p in 3D-hESC-Exosomes, moreover, bioinformatics and dual luciferase reporter assay identified and confirmed the TGFßRII gene as the target of miR-6766-3p. Furthermore, the delivery of miR-6766-3p into activated-LX2 cells decreased cell proliferation, chemotaxis and profibrotic effects, and further investigation demonstrated that the expression of target gene TGFßRII and its downstream SMADs proteins, especially phosphorylated protein p-SMAD2/3 was also notably down-regulated by miR-6766-3p. These findings unveiled that miR-6766-3p in 3D-hESC-Exosomes inactivated SMADs signaling by inhibiting TGFßRII expression, consequently attenuating stellate cell activation and suppressing liver fibrosis. CONCLUSIONS: Our results showed that miR-6766-3p in the 3D-hESC-Exosomes inactivates smads signaling by restraining TGFßRII expression, attenuated LX2 cell activation and suppressed liver fibrosis, suggesting that 3D-hESC-Exosome enriched-miR-6766-3p is a novel anti-fibrotic therapeutics for treating chronic liver disease. These results also proposed a significant strategy that 3D-Exo could be used as natural nanoparticles to rescue liver injury via delivering antifibrotic miR-6766-3p.


Assuntos
Exossomos/metabolismo , Cirrose Hepática/terapia , MicroRNAs/metabolismo , Receptor do Fator de Crescimento Transformador beta Tipo II/metabolismo , Proteínas Smad/metabolismo , Animais , Antagomirs/metabolismo , Técnicas de Cultura de Células em Três Dimensões , Proliferação de Células/efeitos dos fármacos , Colágeno Tipo I/metabolismo , Modelos Animais de Doenças , Exossomos/química , Células-Tronco Embrionárias Humanas/citologia , Células-Tronco Embrionárias Humanas/metabolismo , Humanos , Masculino , Camundongos , Camundongos Endogâmicos ICR , MicroRNAs/antagonistas & inibidores , MicroRNAs/genética , Interferência de RNA , RNA Interferente Pequeno/metabolismo , Receptor do Fator de Crescimento Transformador beta Tipo II/antagonistas & inibidores , Receptor do Fator de Crescimento Transformador beta Tipo II/genética , Transdução de Sinais , Fator de Crescimento Transformador beta/farmacologia
8.
Inorg Chem ; 58(8): 4718-4721, 2019 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-30912651

RESUMO

A magnetite/iron foil (MIF) composite was synthesized as a heterogeneous Fenton-like catalyst. The MIF catalyst effectively degraded Rhodamine B under neutral conditions (degradation efficiency = 86%), avoiding the procedure of pH adjustment. The MIF catalyst could be conveniently recycled without filtration, and the advantages of the stability and reusability of a MIF catalyst made it promising in practical wastewater treatment.

9.
Opt Lett ; 43(13): 3021-3024, 2018 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-29957771

RESUMO

A terahertz spatial modulator is the critical component for active terahertz imaging using compressive sensing. Here small silicon pieces were put in arrays on flexible polymer substrate to fabricate semiconductor terahertz spatial modulators. By doing this, the inter-diffusion of photo-generated charge carriers is prevented for better resolution, and flexibility is achieved. Since the size of silicon is comparable to the wavelength of the terahertz wave, and the dielectric properties of the gap are very different from silicon, the optical modulation of each element is very different from the large silicon. In this Letter, the terahertz wave interaction and optical modulation of the small silicon are systematically studied by time domain spectroscopy. Notably, a strong resonance-like absorption peak was observed in a transmittance spectrum for the small silicon due to the size and edge effect. The spatial modulation of the terahertz wave was also compared between the silicon array and the large silicon samples.

10.
Inorg Chem ; 57(16): 10249-10256, 2018 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-30074777

RESUMO

Heterostructured TiO2 materials are of great importance in electronic and photochemical related applications. We report herein a simple, low-cost, and scalable fabrication of metal oxides heterostructured TiO2 nanotube arrays (NTAs) through a combined strategy of thermal decomposition and crystallization. Various M xO y/TiO2 heterostructured films (M = Zn, Ce, Cu, Cr...) were obtained by using TiO2 NTAs as "nano-containers" as well as "nano-reactors", while using M(CH3COO) x solutions as the precursors. SEM, XRD, EDS results demonstrated that Cu2O/TiO2 NTAs, ZnO/TiO2 NTAs, Cr2O3/TiO2 NTAs, and CeO2/TiO2 NTAs were successfully fabricated. Photocatalytic results revealed that the heterostructured M xO y/TiO2 films could either enhance the UV photocatalytic activities or enable the visible light photocatalytic activities of the TiO2 NTAs. This study provides a facile general approach to prepare M xO y/TiO2 NTAs films, which could be very useful for environmental and energy areas.

11.
Can J Neurol Sci ; 45(2): 182-187, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29506601

RESUMO

BACKGROUND: Parkinson's disease (PD) is a degenerative disorder of the central nervous system mainly affecting the motor system. Presently, there is no effective and safe drug to treat patients with PD. Ginkgo biloba extract (GBE), obtained from leaves of the Ginkgo biloba tree, is a complex mixture of ingredients primarily containing two active components: flavonoids and terpenoids. In this study, we investigated the effects of GBE on A53T α-synuclein transgenic mice, a PD model that has better simulated the progression of PD patients than other models such as the 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced PD model. METHODS: Fifty α-synuclein A53T transgenic mice were fed and treated with GBE, and locomotor activity was detected by pole test, forced swim test, and wire-hang test. The expression of tyrosine hydroxylase and dopamine transporters was detected using immunohistochemistry. Superoxide dismutase activity, glutathione peroxidase activity, and malondialdehyde expression were detected using an assay kit. RESULTS: Our results show that GBE treatment improved locomotor activity and that superoxide dismutase and glutathione peroxidase inhibited the expression of methane dicarboxylic aldehyde and recovered the expression of tyrosine hydroxylase and dopamine transporters. CONCLUSIONS: The GBE treatment improved locomotor activity and inhibited the development of PD in the A53T α-synuclein transgenic mice, which may be partly responsible for decreased oxidative damage and maintain the normal dopamine homeostasis.


Assuntos
Antiparkinsonianos/uso terapêutico , Mutação/genética , Doença de Parkinson/tratamento farmacológico , Doença de Parkinson/genética , Extratos Vegetais/uso terapêutico , alfa-Sinucleína/genética , Alanina/genética , Animais , Modelos Animais de Doenças , Proteínas da Membrana Plasmática de Transporte de Dopamina/metabolismo , Relação Dose-Resposta a Droga , Ginkgo biloba , Glutationa/metabolismo , Glutationa Peroxidase/metabolismo , Locomoção/efeitos dos fármacos , Malondialdeído/metabolismo , Camundongos , Camundongos Transgênicos , Força Muscular/efeitos dos fármacos , Força Muscular/fisiologia , Superóxido Dismutase/metabolismo , Natação/psicologia , Treonina/genética
12.
J Pharmacol Sci ; 134(1): 45-54, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28461003

RESUMO

Depression is a common mental disorder and a leading cause of disability. At its most severe, it can lead to suicide. Recently, there has been growing interest in the application of natural herbs for the prevention and treatment of depression. In this report, we found that the ginsenoside active component Rg3 has an apparent antidepressant effect. In N-methyl-d-aspartic acid (NMDA)-treated HT22 murine hippocampal neuronal cells, Rg3 recovered proliferation and inhibited apoptosis by altering the cell cycle. More interestingly, Rg3 led to apparent physiological behavior change in a chronic mild stress model as seen in forced swim, tail suspension, and sucrose preference tests. This effect was mediated by the phosphorylation of cAMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) signaling. This study provides direct evidence to support the antidepressant effects of ginsenoside Rg3, potentially indicating its application in the treatment of clinical depression.


Assuntos
Antidepressivos/farmacologia , Depressão/tratamento farmacológico , Ginsenosídeos/farmacologia , Neurônios/efeitos dos fármacos , Estresse Psicológico/tratamento farmacológico , Animais , Antidepressivos/química , Antidepressivos/metabolismo , Fator Neurotrófico Derivado do Encéfalo/metabolismo , Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo , Modelos Animais de Doenças , Feminino , Ginsenosídeos/química , Ginsenosídeos/metabolismo , Hipocampo/citologia , Humanos , Transtornos Mentais , Camundongos , Camundongos Endogâmicos C57BL , N-Metilaspartato/farmacologia , Neurônios/citologia , Neurônios/metabolismo , Fosforilação , Transdução de Sinais/efeitos dos fármacos
13.
J ECT ; 33(3): 152-159, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28263242

RESUMO

OBJECTIVE: The aim of this study was to investigate how the combined use of dexmedetomidine with intravenous anesthetics influences seizure duration and circulatory dynamics in electroconvulsive therapy (ECT). METHODS: A literature search was performed to identify studies that evaluated the effect of dexmedetomidine on motor- or electroencephalogram (EEG)-based seizure durations and maximum mean arterial pressure (MAP) and heart rate (HR) after ECT. Moreover, recovery time and post-ECT agitation were evaluated. RESULTS: Six studies enrolling 166 patients in 706 ECT sessions were included. There was no significant difference in motor or EEG seizure duration between dexmedetomidine and nondexmedetomidine groups [motor: 6 studies; mean difference (MD), 1.62; 95% confidence interval (CI), -2.24 to 5.49; P = 0.41; EEG: 3 studies; MD, 2.34; 95% CI, -6.03 to 10.71; P = 0.58]. Both maximum MAP and HR after ECT were significantly reduced in the dexmedetomidine group (MAP: 6 studies; MD, -4.83; 95% CI, -8.43 to -1.22; P = 0.009; HR: 6 studies; MD, -6.68; 95% CI, -10.74 to -2.62; P = 0.001). Moreover, the addition of dexmedetomidine did not significantly prolong recovery time when the reduced-dose propofol was used (4 studies; MD, 63.27; 95% CI, -15.41 to 141.96; P = 0.12). CONCLUSIONS: The use of dexmedetomidine in ECT did not interfere with motor and EEG seizure durations but could reduce maximum MAP and HR after ECT. Besides, the addition of dexmedetomidine in ECT did not prolong recovery time when reduced-dose propofol was used. It might be worthwhile for patients to receive dexmedetomidine before the induction of anesthesia in ECT.


Assuntos
Anestesia/métodos , Anestésicos , Dexmedetomidina , Eletroconvulsoterapia/métodos , Hipnóticos e Sedativos , Quimioterapia Combinada , Humanos , Convulsões
14.
Toxicol Appl Pharmacol ; 305: 143-152, 2016 08 15.
Artigo em Inglês | MEDLINE | ID: mdl-27282297

RESUMO

Chronic exposure to cadmium compounds (Cd(2+)) is one of the major public health problems facing humans in the 21st century. Cd(2+) in the human body accumulates primarily in the kidneys which leads to renal dysfunction and other adverse health effects. Efforts to find a safe and effective drug for removing Cd(2+) from the kidneys have largely failed. We developed and synthesized a new chemical, sodium (S)-2-(dithiocarboxylato((2S,3R,4R,5R)-2,3,4,5,6 pentahydroxyhexyl)amino)-4-(methylthio) butanoate (GMDTC). Here we report that GMDTC has a very low toxicity with an acute lethal dose (LD50) of more than 10,000mg/kg or 5000mg/kg body weight, respectively, via oral or intraperitoneal injection in mice and rats. In in vivo settings, up to 94% of Cd(2+) deposited in the kidneys of Cd(2+)-laden rabbits was removed and excreted via urine following a safe dose of GMDTC treatment for four weeks, and renal Cd(2+) level was reduced from 12.9µg/g to 1.3µg/g kidney weight. We observed similar results in the mouse and rat studies. Further, we demonstrated both in in vitro and in animal studies that the mechanism of transporting GMDTC and GMDTC-Cd complex into and out of renal tubular cells is likely assisted by two glucose transporters, sodium glucose cotransporter 2 (SGLT2) and glucose transporter 2 (GLUT2). Collectively, our study reports that GMDTC is safe and highly efficient in removing deposited Cd(2+) from kidneys assisted by renal glucose reabsorption system, suggesting that GMDTC may be the long-pursued agent used for preventive and therapeutic purposes for both acute and chronic Cd(2+) exposure.


Assuntos
Cádmio/metabolismo , Quelantes/farmacologia , Glucosamina/análogos & derivados , Rim/metabolismo , Metionina/análogos & derivados , Animais , Cádmio/sangue , Cádmio/urina , Linhagem Celular , Quelantes/toxicidade , Feminino , Glucosamina/farmacologia , Glucosamina/toxicidade , Glucose/metabolismo , Transportador de Glucose Tipo 2/metabolismo , Humanos , Masculino , Metionina/farmacologia , Metionina/toxicidade , Coelhos , Ratos Sprague-Dawley , Transportador 2 de Glucose-Sódio/metabolismo , Testes de Toxicidade Aguda , Testes de Toxicidade Subcrônica
15.
Zhonghua Yi Xue Za Zhi ; 95(39): 3190-5, 2015 Oct 20.
Artigo em Zh | MEDLINE | ID: mdl-26814116

RESUMO

OBJECTIVE: This study aimed to investigate the resting-state functional connectivity of the hypothalamus and its relationships with gonadal steroid hormones and depression symptoms in perimenopausal women. METHODS: Total 66 perimenopausal women voluntarily participated in this study from October 2012 to June 2013. Zung Self-rating Depression Scale (ZSDS) was used to assess depression symptoms. Plasma gonadal steroid hormones including estradiol, testosterone, and progesterone were determined by the chemiluminescence immunoassay. A 3.0 Tesla magnetic resonance imaging (MRI) scanner was utilized to acquire resting-state functional MRI data. The z-value functional connectivity map of each participant was calculated voxel-wisely based on the seed region of the hypothalamus. One sample t test of Statistical Parametric Mapping (SPM) were used to determine the brain areas with statistically significant functional connectivity to the hypothalamus, then multiple regression of SPM was used to calculate the correlated areas with 3 gonadal steroid hormones, respectively. Finally, Pearson correlation was performed to analyze bivariate correlations between mean z-values and ZSDS scores. RESULTS: Significant functional connectivity to the hypothalamus were found in brain areas as follows:the lateral inferior frontal gyrus, medial prefrontal cortex, dorsal lateral prefrontal cortex, orbitofrontal cortex, subgenual cortex, anterior cingulate cortex, posterior cingulate cortex, cuneus and precuneus, hippocampus and parahippocampal gyrus, and angular gyrus (False Discovery Rate q<0.05). Among these areas, the plasma testosterone level was positively related to the functional connectivity strength of the right angular gyrus, and negatively related to the strengths of the right subgenual cortex and bilateral medial superior frontal gyrus to the hypothalamus (PAlphaSim<0.05). Especially, mean z-value in the subgenual cortex was positively related to the ZSDS index score (r=0.279, P=0.023), and factor scores of the core depression symptoms (r=0.278, P=0.024) and somatic symptoms (r=0.357, P=0.003). CONCLUSION: In perimenopausal women, the hypothalamus has resting-state functional connectivity with widespread areas involved in the brain depression-related network and default mode network, and the plasma androgen level may modulate the functional connectivity strengths of the hypothalamus and decrease the susceptibility of perimenopausal women to depression.


Assuntos
Depressão , Transtorno Depressivo , Perimenopausa , Encéfalo , Mapeamento Encefálico , Feminino , Hormônios Esteroides Gonadais , Humanos , Imageamento por Ressonância Magnética
16.
J Clin Psychopharmacol ; 34(4): 495-8, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24943388

RESUMO

OBJECTIVE: This study aims to investigate the effects of low-dose olanzapine on preventing occurrence and controlling the severity of nausea and vomiting related to duloxetine in treating major depressive disorder. METHODS: Two hundred sixty-eight subjects with major depressive disorder were divided into control and trial groups. The control group had 165 subjects and was treated with duloxetine only, whereas the trial group had 103 subjects and received duloxetine combined with low-dose olanzapine. After the treatment for 2 weeks, both groups were evaluated for occurrence and severity of adverse effects on digestive tract using the Treatment Emergent Symptom Scale. RESULTS: The trial group, scored at 13, showed significantly less occurrence and severity of nausea and vomiting than the control group, scored at 38 (P < 0.05). The occurrence of nausea and vomiting in the trial group is significantly lower compared with that in the control group, and the occurrence decreases as the dose of olanzapine increases (P < 0.05). The antiemetic effect of olanzapine is valid to all subjects who received it. CONCLUSIONS: Duloxetine combined with low-dose olanzapine can effectively reduce the occurrence and severity of duloxetine-related nausea and vomiting. With the increase of olanzapine dose, the antiemetic effect becomes stronger. Olanzapine is a safe and efficient drug for the prevention of duloxetine-related nausea and vomiting.


Assuntos
Antieméticos/administração & dosagem , Benzodiazepinas/administração & dosagem , Transtorno Depressivo Maior/tratamento farmacológico , Náusea/tratamento farmacológico , Tiofenos/administração & dosagem , Vômito/tratamento farmacológico , Adolescente , Adulto , Antidepressivos/administração & dosagem , Antidepressivos/efeitos adversos , Transtorno Depressivo Maior/diagnóstico , Transtorno Depressivo Maior/psicologia , Esquema de Medicação , Quimioterapia Combinada , Cloridrato de Duloxetina , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Náusea/induzido quimicamente , Náusea/diagnóstico , Olanzapina , Tiofenos/efeitos adversos , Resultado do Tratamento , Vômito/induzido quimicamente , Vômito/diagnóstico , Adulto Jovem
17.
BMC Psychiatry ; 14: 367, 2014 Dec 24.
Artigo em Inglês | MEDLINE | ID: mdl-25539808

RESUMO

BACKGROUND: Subsyndromal depression (SSD) is considered as a predictor for future depressive disorders, however whether white matter abnormalities are involved in the high-susceptibility of women to depressive disorders during perimenopause is unknown. The purpose of this study was to investigate fractional anisotropy (FA) in the white matter of the whole brain in perimenopausal women with SSD using diffusion tensor imaging (DTI). METHODS: In a cross-sectional study, 24 perimenopausal women with SSD and 24 other age-, education-, and body mass index-matched healthy women underwent DTI. A voxel-based analysis was used to elucidate regional FA changes at a voxel threshold of p < 0.001 with an extent threshold of k > 127 voxels (p < 0.05, AlphaSim correction). Subsequently, correlation analyses were performed between mean FA values in significant brain regions and plasma estradiol level. RESULTS: Compared to healthy controls, women with SSD exhibited significantly lower FA values in the left insula, while higher FA values were observed in the left ventral lateral thalamus and left and right brainstem in the midbrain. In subjects with SSD, the mean FA value in the left insula was positively correlated to plasma estradiol levels (r = 0.453, p = 0.026) (uncorrected). CONCLUSIONS: Our findings indicate altered microstructures in white matter of the insula and subcortical regions may be associated with the high susceptibility of perimenopausal women to depressive disorders. Estrogen may modulate the white matter microstructure of the insula.


Assuntos
Transtorno Depressivo/patologia , Perimenopausa/fisiologia , Substância Branca/patologia , Anisotropia , Tronco Encefálico/patologia , Estudos de Casos e Controles , Córtex Cerebral/patologia , Estudos Transversais , Imagem de Tensor de Difusão/métodos , Estradiol/metabolismo , Feminino , Humanos , Mesencéfalo/patologia , Pessoa de Meia-Idade , Núcleos Ventrais do Tálamo/patologia
18.
Front Psychol ; 15: 1359626, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38605835

RESUMO

As a long-established model of schooling, the boarding system is commonly practiced in countries around the world. Numerous scholars have conducted a great deal of research on the relationship between the boarding school and student development, but the results of the research are quite divergent. In order to clarify the real effects of boarding school on students' development, this study used meta-analysis to quantify 49 (91 effect sizes) experimental or quasi-experimental studies on related topics at home and abroad. The results find that: (1) Overall, boarding school has no significant predictive effect on student development, with a combined effect size of 0.002 (p > 0.05); (2) Specifically, boarding school has a significant positive predictive effect on students' cognitive development (g = 0.248, p < 0.001), a significant negative predictive effect on students' affective and attitudinal development (g = -0.159, p < 0.05), and no significant predictive effect on students' behavioral development (g = -0.115, p > 0.05) and physical development (g = -0.038, p > 0.05); (3) The relationship between the two is moderated by the school stage and the type of boarding school, but not by the instruments; (4) Compared with primary school students, senior high school students and urban boarding students, the negative predictive effect of boarding system on junior middle school students and rural boarding students is more significant. In addition, there are some limitations in the study, such as the limited number of moderator variables included, the results of the study are easily affected by the quality of the included literature, and the dimensionality of the core variable "student development" is not comprehensive enough. In the future, further validation should be conducted through in-depth longitudinal or experimental studies.

19.
J Colloid Interface Sci ; 660: 124-135, 2024 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-38241861

RESUMO

TiO2, ZrO2 and a series of TiO2-ZrO2 (TxZ1, x means the atomic ratio of Ti/Zr = 10, 5, 1, 0.2 and 0.1) composite oxide supports were prepared through co-precipitation, and then 3 wt% Co was loaded through wetness impregnation methods. The obtained 3 wt% Co/TiO2 (3CT), 3 wt% Co/ZrO2 (3CZ) and 3 wt% Co/TxZ1 (3CTxZ1) catalysts were evaluated for the oxidative ethane dehydrogenation reaction with CO2 (CO2-ODHE) as a soft oxidant. 3CT1Z1 catalyst exhibits excellent catalytic properties, with C2H4 yield, C2H6 conversion and CO2 conversion about 24.5 %, 33.8 % and 18.0 % at 650 °C, respectively. X-Ray Diffraction (XRD), in-situ Raman, UV-vis diffuse reflectance spectra (UV-vis DRS), H2 temperature-programmed reduction (H2-TPR), Electron paramagnetic resonance (EPR) and quasi in-situ X-ray Photoelectron Spectroscopy (XPS) have been utilized to thoroughly characterize the investigated catalysts. The results revealed that 3CT1Z1 produced TiZrO4 solid solution with more metal defect sites and oxygen vacancies (Ov), promoting the formation of Co2+-TiZrO4 structure. Furthermore, the presence of Ov and Ti3+can facilitate the high dispersion and stabilization of Co2+, as well as suppressing the severe reduction of Co2+, leading to superior ethane oxidative dehydrogenation activity. Besides, less Co0 is beneficial to ODHE reaction, because of its promotion effects for reverse water gas shift reaction; however, more Co0 results in dry reforming reaction (DRE). This work will shed new lights for the design and preparation of highly efficient catalysts for ethylene production.

20.
ACS Appl Mater Interfaces ; 16(24): 31438-31446, 2024 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-38843313

RESUMO

Spin-orbit torque (SOT) has emerged as an effective means of manipulating magnetization. However, the current energy efficiency of SOT operation is inefficient due to low damping-like SOT efficiency per unit current bias. In this work, we dope conventional rare earth oxides, GdOy, into highly conductive platinum by magnetron sputtering to form a new group of spin Hall materials. A large damping-like spin-orbit torque (DL-SOT) efficiency of about 0.35 ± 0.013 is obtained in Pt0.70(GdOy)0.30 measured by the spin-torque ferromagnetic resonance (ST-FMR) technique, which is about five times that of pure Pt under the same conditions. The substantial enhancement of the spin Hall effect is revealed by theoretical analysis to be attributed to the strong side jump induced by the rare earth oxide GdOy impurities. Moreover, this large DL-SOT efficiency contributes to a low critical switching current density (8.0 × 106 A·cm-2 in the Pt0.70(GdOy)0.30 layer) in current-induced magnetization switching measurements. This systematic study on SOT switching properties suggests that Pt1-x(GdOy)x is an attractive spin current source with large DL-SOT efficiency for future SOT applications and provides another idea to regulate the spin Hall angle.

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