Detalhe da pesquisa
1.
"PROTAC" modified dihydroquinolizinones (DHQs) that cause degradation of PAPD-5 and inhibition of hepatitis A virus and hepatitis B virus, in vitro.
Bioorg Med Chem Lett
; 102: 129680, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38428537
2.
A putative amphipathic alpha helix in hepatitis B virus small envelope protein plays a critical role in the morphogenesis of subviral particles.
J Virol
; 95(8)2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33536177
3.
The Dihydroquinolizinone Compound RG7834 Inhibits the Polyadenylase Function of PAPD5 and PAPD7 and Accelerates the Degradation of Matured Hepatitis B Virus Surface Protein mRNA.
Antimicrob Agents Chemother
; 65(1)2020 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33046485
4.
Activation of Stimulator of Interferon Genes in Hepatocytes Suppresses the Replication of Hepatitis B Virus.
Antimicrob Agents Chemother
; 61(10)2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28717041
5.
Novel Woodchuck Hepatitis Virus (WHV) transgene mouse models show sex-dependent WHV replicative activity and development of spontaneous immune responses to WHV proteins.
J Virol
; 88(3): 1573-81, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24257601
6.
Host RNA quality control as a hepatitis B antiviral target.
Antiviral Res
; 186: 104972, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33242518
7.
Hepatoselective Dihydroquinolizinone Bis-acids for HBsAg mRNA Degradation.
ACS Med Chem Lett
; 12(7): 1130-1136, 2021 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34267883
8.
Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases.
Emerg Microbes Infect
; 10(1): 852-864, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33870849
9.
Proteomic analysis of primary duck hepatocytes infected with duck hepatitis B virus.
Proteome Sci
; 8: 28, 2010 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20529248
10.
Scalable Synthesis, In Vitro cccDNA Reduction, and In Vivo Antihepatitis B Virus Activity of a Phosphonomethoxydeoxythreosyl Adenine Prodrug.
J Med Chem
; 63(22): 13851-13860, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33191744
11.
Virological Basis for the Cure of Chronic Hepatitis B.
ACS Infect Dis
; 5(5): 659-674, 2019 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29893548
12.
HBsAg mRNA degradation induced by a dihydroquinolizinone compound depends on the HBV posttranscriptional regulatory element.
Antiviral Res
; 149: 191-201, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29133129
13.
Alpha interferon-induced antiviral response noncytolytically reduces replication defective adenovirus DNA in MDBK cells.
Antiviral Res
; 76(3): 232-40, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17897730
14.
Hepatitis B virus e antigen production is dependent upon covalently closed circular (ccc) DNA in HepAD38 cell cultures and may serve as a cccDNA surrogate in antiviral screening assays.
Antiviral Res
; 72(2): 116-24, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16780964
15.
Evolving New Strategies for the Medical Management of Chronic Hepatitis B Virus Infection.
Gastroenterol Hepatol (N Y)
; 12(11): 679-689, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28035197
16.
Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53.
Nat Commun
; 6: 8651, 2015 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26471002
17.
Characterization of the host factors required for hepadnavirus covalently closed circular (ccc) DNA formation.
PLoS One
; 7(8): e43270, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22912842
18.
Rapid and sensitive detection of hepatitis B virus 1762T/1764A double mutation from hepatocellular carcinomas using LNA-mediated PCR clamping and hybridization probes.
J Virol Methods
; 158(1-2): 24-9, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19187787
19.
The degradation pathway for the HBV envelope proteins involves proteolysis prior to degradation via the cytosolic proteasome.
Virology
; 369(1): 69-77, 2007 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17716702
20.
Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway.
J Virol
; 81(18): 10072-80, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17609269