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1.
Funct Integr Genomics ; 20(3): 343-353, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31659573

RESUMO

Evidence from biochemical liver function index and histopathology analysis suggested that selenium could effectively repair the liver injury caused by beta-cypermethrin (ß-CYP). However, the molecular mechanism of selenium against liver injury induced by ß-CYP remains unclear. In the present study, dynamic changes in gene expression profiles before and after the treatment of Na2SeO3 in liver injury mice were analyzed by using RNA sequencing. As a result, several essential genes and pathways were identified to be significantly associated with this process. In particular, ten genes including Cyp2j11, Cyp2b10, Cyp3a13, Dhrs9, Socs2, Stat4, Gm13305, Cyp3a44, Retsat, and Cyp26b1 were significantly enriched in the functional categories related to retinol metabolism, linoleic acid metabolism, and Jak-STAT signaling pathway. Among them, the expression patterns of nine genes were validated by qRT-PCR, except for Cyp3a44. Furthermore, we have constructed the associated regulatory network based on the identified targets revealed by high throughput screening. Our study may provide insight into the molecular mechanism underlying the protective effect of selenium against liver injury induced by ß-CYP in mammals.


Assuntos
Doença Hepática Induzida por Substâncias e Drogas/genética , Fígado/metabolismo , Selênio/farmacologia , Transcriptoma , Animais , Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Doença Hepática Induzida por Substâncias e Drogas/metabolismo , Sistema Enzimático do Citocromo P-450/genética , Sistema Enzimático do Citocromo P-450/metabolismo , Inseticidas/toxicidade , Janus Quinases/genética , Janus Quinases/metabolismo , Fígado/efeitos dos fármacos , Camundongos , Piretrinas/toxicidade , Fatores de Transcrição STAT/genética , Fatores de Transcrição STAT/metabolismo , Selênio/uso terapêutico
2.
Front Psychol ; 14: 1139687, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37026082

RESUMO

Background: Ceramic tiles are popular because of their various forms, and they are often used to decorate the environment. However, few studies have applied objective methods to explore the implicit preference and visual attention of people toward ceramic tile features. Using event-related potential technology can provide neurophysiological evidence for the study and applications of tiles. Materials and methods: This study explored the influence of pattern, lightness, and color system factors of ceramic tiles on the preferences of people using a combination of subjective questionnaires and event-related potential (ERP) technology. Twelve different conditions of tiles (2 × 3 × 2) were used as stimuli. EEG data were collected from 20 participants while they watched the stimuli. Subjective preference scores and average ERPs were analyzed using analysis of variance and correlation analysis. Results: (1) Pattern, lightness, and color system factors significantly affected the subjective preference scores for tiles; the unpatterned tiles, light-toned tiles, and warm-colored tiles received higher preference scores. (2) The preferences of people for different features of tiles moderated ERP amplitudes. (3) The light-toned tiles with a high preference score caused a greater N100 amplitude than the medium-toned and dark-toned tiles; and the patterned tiles and warm-colored tiles with low preference scores induced greater P200 and N200 amplitudes. Discussion: In the early stage of visual processing, light-toned tiles attracted more attention, possibly because of the positive emotional effects related to the preference. The greater P200 and N200 elicited by the patterned and neutral-colored tiles in the middle stage of visual processing indicates that patterned and neutral-colored tiles attracted more attention. This may be due to negativity bias, where more attention is allocated to negative stimuli that people strongly dislike. From the perspective of cognitive processes, the results indicate that the lightness of ceramic tiles is the factor that people first detect, and the visual processing of pattern and color system factors of ceramic tiles belong to a higher level of visual processing. This study provides a new perspective and relevant information for assessing the visual characteristics of tiles for environmental designers and marketers involved in the ceramic tiles industry.

3.
Pharmacol Ther ; 240: 108284, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-36162728

RESUMO

Polycystic ovary syndrome (PCOS) affects approximately 15% of women of reproductive age worldwide. It is the most prevalent endocrine disorder with marked risks for female infertility, type 2 diabetes mellitus (T2DM), psychiatric disorders and gynecological cancers. Although the pathophysiology of PCOS remains largely elusive, growing evidence suggests a close link with obesity and its related metabolic disorders. As a highly active endocrine cell population, hypertrophic adipocytes in obesity have disturbed production of a vast array of adipokines, biologically active peptides that exert pleiotropic effects on homeostatic regulation of glucose and lipid metabolism. In parallel with their crucial roles in the pathophysiology of obesity-induced metabolic diseases, adipokines have recently been identified as promising targets for novel therapeutic strategies for multiple diseases. Current treatments for PCOS are suboptimal with insufficient alleviation of all symptoms. Novel findings in adipokine-targeted agents may provide important insight into the development of new drugs for PCOS. This Review presents an overview of the current understanding of mechanisms that link PCOS to obesity and highlights emerging evidence of adipose-ovary crosstalk as a pivotal mediator of PCOS pathogenesis. We summarize recent findings of preclinical and clinical studies that reveal the therapeutic potential of adipokine-targeted novel approaches to PCOS and its related metabolic disorders. We also discuss the critical gaps in knowledge that need to be addressed to guide the development of adipokine-based novel therapies for PCOS.


Assuntos
Diabetes Mellitus Tipo 2 , Resistência à Insulina , Doenças Metabólicas , Síndrome Metabólica , Síndrome do Ovário Policístico , Feminino , Humanos , Síndrome do Ovário Policístico/tratamento farmacológico , Síndrome do Ovário Policístico/diagnóstico , Síndrome do Ovário Policístico/metabolismo , Adipocinas/metabolismo , Diabetes Mellitus Tipo 2/complicações , Resistência à Insulina/fisiologia , Doenças Metabólicas/tratamento farmacológico , Obesidade/tratamento farmacológico , Obesidade/complicações
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