Detalhe da pesquisa
1.
Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and Extrahepatic Metabolism.
Drug Metab Dispos
; 52(2): 106-117, 2024 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38071562
2.
Metabolite characterisation of the peptide-drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS.
Xenobiotica
; 54(1): 1-9, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38044881
3.
Detection and Characterization of In Vitro Payload-Containing Catabolites of Noncleavable Antibody-Drug Conjugates by High-Resolution Mass Spectrometry and Multiple Data Mining Tools.
Drug Metab Dispos
; 51(5): 591-598, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36707253
4.
High-Throughput Metabolic Soft-Spot Identification in Liver Microsomes by LC/UV/MS: Application of a Single Variable Incubation Time Approach.
Molecules
; 27(22)2022 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36432161
5.
Metabolic disposition of [14 C]-abivertinib, an epidermal growth factor receptor tyrosine kinase inhibitor: Role of glutathione conjugation.
Br J Clin Pharmacol
; 87(3): 1475-1485, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32959915
6.
Artificial intelligence and network pharmacology based investigation of pharmacological mechanism and substance basis of Xiaokewan in treating diabetes.
Pharmacol Res
; 159: 104935, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32464328
7.
Rapid detection and structural characterization of verapamil metabolites in rats by UPLC-MSE and UNIFI platform.
Biomed Chromatogr
; 34(1): e4702, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31633811
8.
Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.
Mol Pharm
; 16(9): 4065-4076, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31335150
9.
Metabolomics-based parallel discovery of xenobiotics and induced endogenous metabolic dysregulation in clinical toxicology.
Biomed Chromatogr
; 33(2): e4413, 2019 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-30357883
10.
Biotransformation of Ilaprazole in Human Liver Microsomes and Human: Role of CYP3A4 in Ilaprazole Clearance and Drug-Drug Interaction.
Drug Metab Dispos
; 46(10): 1453-1461, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30002078
11.
LC-MS Differential Analysis for Fast and Sensitive Determination of Biotransformation of Therapeutic Proteins.
Drug Metab Dispos
; 46(4): 451-457, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29386233
12.
Human Hepatocyte Metabolism of Novel Synthetic Cannabinoids MN-18 and Its 5-Fluoro Analog 5F-MN-18.
Clin Chem
; 63(11): 1753-1763, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28821542
13.
An Integrated Approach for Studying Exposure, Metabolism, and Disposition of Multiple Component Herbal Medicines Using High-Resolution Mass Spectrometry and Multiple Data Processing Tools.
Drug Metab Dispos
; 44(6): 800-8, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27013399
14.
Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement.
Drug Metab Dispos
; 44(6): 809-20, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27029743
15.
Applications of mass spectrometry in drug metabolism: 50 years of progress.
Drug Metab Rev
; 47(1): 71-87, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25639893
16.
Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation.
Drug Metab Dispos
; 42(2): 245-9, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24301608
17.
Metabolism of synthetic cannabinoids PB-22 and its 5-fluoro analog, 5F-PB-22, by human hepatocyte incubation and high-resolution mass spectrometry.
Anal Bioanal Chem
; 406(6): 1763-80, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24518903
18.
First metabolic profile of XLR-11, a novel synthetic cannabinoid, obtained by using human hepatocytes and high-resolution mass spectrometry.
Clin Chem
; 59(11): 1638-48, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24014837
19.
Global Xenobiotic Profiling of Rat Plasma Using Untargeted Metabolomics and Background Subtraction-Based Approaches: Method Evaluation and Comparison.
Curr Drug Metab
; 24(3): 200-210, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37157207
20.
Conference report for the 10th China Bioanalysis Forum annual meeting.
Bioanalysis
; 15(24): 1469-1472, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37933576