Primary results of the brazilian registry of atherothrombotic disease (NEAT).

There is limited contemporary prospective real-world evidence of patients with chronic arterial disease in Latin America. The Network to control atherothrombosis (NEAT) registry is a national prospective observational study of patients with known coronary (CAD) and/or peripheral arterial disease (PAD) in Brazil. A total of 2,005 patients were enrolled among 25 sites from September 2020 to March 2022. Patient characteristics, medications and laboratorial data were collected. Primary objective was to assess the proportion of patients who, at the initial visit, were in accordance with good medical practices (domains) for reducing cardiovascular risk in atherothrombotic disease. From the total of patients enrolled, 2 were excluded since they did not meet eligibility criteria. Among the 2,003 subjects included in the analysis, 55.6% had isolated CAD, 28.7% exclusive PAD and 15.7% had both diagnoses. Overall mean age was 66.3 (± 10.5) years and 65.7% were male patients. Regarding evidence-based therapies (EBTs), 4% were not using any antithrombotic drug and only 1.5% were using vascular dose of rivaroxaban (2.5 mg bid). Only 0.3% of the patients satisfied all the domains of secondary prevention, including prescription of EBTs and targets of body-mass index, blood pressure, LDL-cholesterol, and adherence of lifestyle recommendations. The main barrier for prescription of EBTs was medical judgement. Our findings highlight that the contemporary practice does not reflect a comprehensive approach for secondary prevention and had very low incorporation of new therapies in Brazil. Large-scale populational interventions addressing these gaps are warranted to improve the use of evidence-based therapies and reduce the burden of atherothrombotic disease.ClinicalTrials.gov NCT04677725.

Expression of microRNAs (133b and 138) and Correlation with Echocardiographic Parameters in Patients with Alcoholic Cardiomyopathy.

INTRODUCTION: Alcoholic Cardiomyopathy (ACM) is a disease with a difficult diagnosis. The real mechanisms related to its pathophysiology are not fully understood. OBJECTIVE: The aims of this study were to investigate whether miR-133b and miR-138 could be associated with ACM. METHODS: Forty-four patients were included comprising 24 with ACM and 20 with cardiomyopathies of different etiologies (control group). Real-time PCR was performed to verify the relative expression among the studied groups. In the statistical analysis, the quantitative variables t-student Mann- Whitney and correlation of Pearson tests were carried out, while the qualitative variable comprised the chi-square test, with p<0.05 being considered statistically significant. RESULTS: There was no association between clinical and sociodemographic characteristics of the groups. The patients with ACM presented downregulation of miR-133b in comparison with control patients (p=0.004). On the other hand, for the miR-138, there was no association when the ACM group was compared with the control group. The presence of miR-133b among cases and controls was not correlated with any of the echocardiographic parameters. However, the increase in the expression of miR-138 was correlated with an increase in the ejection fraction (r=0.28, p=0.01) and the diameter of the left atrium (r=0.23, p=0.04) in patients with ACM. CONCLUSION: The downregulation of miR-133b might be a marker for ACM and, in addition, miR- 138 could be used to correlate the increase in ejection fraction with and normalization of the diameter of the left atrium diameter in patients with this disease.

Diálogo sobre a construção de um mapa conceitual como recurso para aprendizagem: relato de experiência / Discussion on the development of a conceptual map as a learning tool: an experience report

Resumen:

Objetivo: describir la experiencia de los estudiantes sobre la construcción de un mapa conceptual como un recurso para el aprendizaje. Metodología e intervenciones: es un relato de los estudiantes de enfermería de la Universidad de Ciencias de la Salud de Alagoas -UNCISAL (Brasil) durante la actividad realizada en un plan de estudios de la disciplina. Se lanzó una pregunta sobre un tema y para contestar era necesario construir un mapa conceptual. Resultados: el grupo encontró algunos obstáculos como la falta de madurez y escaso tiempo para desarrollar el pensamiento crítico. Sin embargo, logró establecer relaciones con los conocimientos previos mientras que rompió con los viejos conceptos, desarrollando el pensamiento crítico. Además, la construcción del mapa hizo la autonomía y colectividad, fundamental para el contexto profesional. Discusión: la experiencia permitió a los estudiantes reconocer en el proceso de aprendizaje la importancia de los mapas conceptuales en su formación, ya que su uso está marcado por la autoría, la autonomía y la responsabilidad en el camino del aprendizaje. Esta práctica hace que sean personas más participativas y reflexivas, enriqueciendo el proceso de enseñanza-aprendizaje. Conclusión: este estudio mostró que los estudiantes, aunque poco habituados con las nuevas características ofrecidas por los métodos activos, consideran el mapa conceptual como facilitador del metaaprendizaje, proporcionando la capacidad de este y la autonomía para construir sus propios conceptos

Objetivo: descrever a experiência de discentes sobre a construção de um mapa conceitual como recurso para aprendizagem. Metodologia e intervenções: trata-se de um relato de experiência de acadêmicos de Enfermagem da Universidade de Ciências da Saúde de Alagoas - UNCISAL (Brasil) durante atividade realizada em uma disciplina da matriz curricular. Foi lançada uma questão sobre um tema e para respondê-la era necessário construir um mapa conceitual.

Abstract:

Purpose: to describe the experience of students on the creation of a conceptual map as a learning tool. Methods and interventions: a narrative report by nursing students at Health Sciences University of Alagoas - UNCISAL during their activity included in the curriculum. A question was posed, and a conceptual map was needed to answer it. Results: the group found some barriers including lack of maturity or time limitations to develop critical thinking. However, relationships with previous knowledge were established, while existing ones with old concepts were abandoned, and critical thinking was developed. Furthermore, map development made autonomy and collectivity become a key element in a professional setting. Discussion: the reported experience allowed students to recognize the learning importance of conceptual maps during their training process, because their use involves authorship, autonomy and responsibility all along the learning pathway. Such an experience makes the students become more contributing and thoughtful with teaching-learning processes being enhanced. Conclusion: the present study showed that although students are not familiar with the new features of active methods, they consider conceptual map to help meta-learning with capacities and autonomy being useful to build their own concepts.

Resultados: o grupo encontrou alguns obstáculos como imaturidade e tempo curto para desenvolver a reflexão crítica. Porém, conseguiram estabelecer relação com conhecimento prévio ao mesmo tempo em que romperam com os velhos conceitos, desenvolvendo o pensamento crítico. Além disso, a construção do mapa fez a autonomia e o coletivo se relacionarem, fundamental para o contexto profissional. Discussão: a experiência possibilitou aos universitários, em processo de aprendizado, o reconhecimento da importância dos mapas conceituais em sua formação, já que sua utilização é marcada pela autoria, autonomia e corresponsabilidade na forma de aprender. Tal prática torna o indivíduo mais participativo e reflexivo, enriquecendo o processo ensino-aprendizagem. Conclusão: este estudo mostrou que os discentes, a pesar de imaturos com os novos recursos propostos pelas metodologias ativas, consideram o mapa conceitual como um facilitador da meta-aprendizagem, proporcionando ao aprendiz habilidade e autonomia para construção de seus próprios conceitos.