1.
Bioorg Med Chem Lett
; 18(6): 2167-71, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18276138
RESUMO
Modified adenosine derivatives may lead to the development of P2Y(12) antagonists that are potent, selective, and bind reversibly to the receptor. Analogues of 2',3'-trans-styryl acetal-N6-ureido-adenosine monophosphate were prepared by modification of the 5'-position. The resulting analogues were tested for P2Y(12) antagonism in a platelet aggregation assay.