Detalhe da pesquisa
1.
The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling.
PLoS Pathog
; 19(2): e1011179, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36848386
2.
Genome-scale deconvolution of RNA structure ensembles.
Nat Methods
; 18(3): 249-252, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33619392
3.
Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies.
PLoS Comput Biol
; 19(4): e1010423, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37014904
4.
R-Propranolol Has Broad-Spectrum Anti-Coronavirus Activity and Suppresses Factors Involved in Pathogenic Angiogenesis.
Int J Mol Sci
; 24(5)2023 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36902020
5.
Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.
J Am Chem Soc
; 144(7): 2905-2920, 2022 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35142215
6.
The Cyclophilin-Dependent Calcineurin Inhibitor Voclosporin Inhibits SARS-CoV-2 Replication in Cell Culture.
Transpl Int
; 35: 10369, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35812159
7.
Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements.
Nucleic Acids Res
; 48(22): 12436-12452, 2020 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33166999
8.
Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication.
Molecules
; 27(3)2022 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35164317
9.
Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Protein 1 Inhibitors.
Antimicrob Agents Chemother
; 65(7): e0256620, 2021 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33875421
10.
Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation.
PLoS Comput Biol
; 16(2): e1007587, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32040506
11.
Small-Molecule Inhibitors of Chikungunya Virus: Mechanisms of Action and Antiviral Drug Resistance.
Antimicrob Agents Chemother
; 64(12)2020 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32928738
12.
Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle.
Antimicrob Agents Chemother
; 64(8)2020 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32513797
13.
Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery.
Antimicrob Agents Chemother
; 64(7)2020 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32340991
14.
6'-ß-Fluoro-Homoaristeromycin and 6'-Fluoro-Homoneplanocin A Are Potent Inhibitors of Chikungunya Virus Replication through Their Direct Effect on Viral Nonstructural Protein 1.
Antimicrob Agents Chemother
; 64(4)2020 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31964798
15.
Purification of Highly Active Alphavirus Replication Complexes Demonstrates Altered Fractionation of Multiple Cellular Membranes.
J Virol
; 92(8)2018 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29367248
16.
Host Factors in Coronavirus Replication.
Curr Top Microbiol Immunol
; 419: 1-42, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-28643204
17.
Dynamics of Chikungunya Virus Cell Entry Unraveled by Single-Virus Tracking in Living Cells.
J Virol
; 90(9): 4745-4756, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26912616
18.
Transactivation of programmed ribosomal frameshifting by a viral protein.
Proc Natl Acad Sci U S A
; 111(21): E2172-81, 2014 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24825891
19.
A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins.
J Virol
; 89(16): 8318-33, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26041291
20.
Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication.
J Virol
; 89(8): 4457-69, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25653451