Detalhe da pesquisa
1.
Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography.
J Pharmacol Exp Ther
; 346(2): 311-7, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23685546
2.
The role of clinical imaging in oncology drug development: progress and new challenges.
Br J Radiol
; 96(1150): 20211126, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37393537
3.
Brain exposure of osimertinib in patients with epidermal growth factor receptor mutation non-small cell lung cancer and brain metastases: A positron emission tomography and magnetic resonance imaging study.
Clin Transl Sci
; 16(6): 955-965, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36808835
4.
Safety and Pharmacokinetics of HTL0018318, a Novel M1 Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects.
Drugs R D
; 21(3): 295-304, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34164794
5.
Safety, pharmacokinetics, and pharmacodynamics of Gln-1062, a prodrug of galantamine.
Alzheimers Dement (N Y)
; 6(1): e12093, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33083515
6.
Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 using an oral dexamphetamine challenge model in healthy males in a randomised, double-blind, placebo-controlled, multiple ascending dose trial.
J Psychopharmacol
; 34(9): 1030-1042, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32248747
7.
Evaluation of the Novel PET Tracer [11C]HACH242 for Imaging the GluN2B NMDA Receptor in Non-Human Primates.
Mol Imaging Biol
; 21(4): 676-685, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30306318
8.
Quantification of human brain PDE4 occupancy by GSK356278: A [11C](R)-rolipram PET study.
J Cereb Blood Flow Metab
; 38(11): 2033-2040, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28737056
9.
First in human evaluation of [18F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors.
EJNMMI Res
; 8(1): 69, 2018 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30054846
10.
Human Dosimetry of the N-Methyl-d-Aspartate Receptor Ligand 11C-GMOM.
J Nucl Med
; 58(8): 1330-1333, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28183990
11.
In vivo occupancy of the 5-HT1A receptor by a novel pan 5-HT1(A/B/D) receptor antagonist, GSK588045, using positron emission tomography.
Neuropharmacology
; 92: 44-8, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25476970
12.
Testing the effects of Δ9-THC and D-cycloserine on extinction of conditioned fear in humans.
J Psychopharmacol
; 26(4): 471-8, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22351380
13.
Radiation dose estimates for carbon-11-labelled PET tracers.
Nucl Med Biol
; 39(2): 305-14, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22033023
14.
Within-subject comparison of [(11)C]-(+)-PHNO and [(11)C]raclopride sensitivity to acute amphetamine challenge in healthy humans.
J Cereb Blood Flow Metab
; 32(1): 127-36, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21878947
15.
Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy.
J Cereb Blood Flow Metab
; 31(3): 944-52, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20940733