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PURPOSE: To identify the key risk factors for venous thromboembolism (VTE) in urological inpatients based on the Caprini scale using an interpretable machine learning method. METHODS: VTE risk data of urological inpatients were obtained based on the Caprini scale in the case hospital. Based on the data, the Boruta method was used to further select the key variables from the 37 variables in the Caprini scale. Furthermore, decision rules corresponding to each risk level were generated using the rough set (RS) method. Finally, random forest (RF), support vector machine (SVM), and backpropagation artificial neural network (BPANN) were used to verify the data accuracy and were compared with the RS method. RESULTS: Following the screening, the key risk factors for VTE in urology were "(C1) Age," "(C2) Minor Surgery planned," "(C3) Obesity (BMI > 25)," "(C8) Varicose veins," "(C9) Sepsis (< 1 month)," (C10) "Serious lung disease incl. pneumonia (< 1month) " (C11) COPD," "(C16) Other risk," "(C18) Major surgery (> 45 min)," "(C19) Laparoscopic surgery (> 45 min)," "(C20) Patient confined to bed (> 72 h)," "(C18) Malignancy (present or previous)," "(C23) Central venous access," "(C31) History of DVT/PE," "(C32) Other congenital or acquired thrombophilia," and "(C34) Stroke (< 1 month." According to the decision rules of different risk levels obtained using the RS method, "(C1) Age," "(C18) Major surgery (> 45 minutes)," and "(C21) Malignancy (present or previous)" were the main factors influencing mid- and high-risk levels, and some suggestions on VTE prevention were indicated based on these three factors. The average accuracies of the RS, RF, SVM, and BPANN models were 79.5%, 87.9%, 92.6%, and 97.2%, respectively. In addition, BPANN had the highest accuracy, recall, F1-score, and precision. CONCLUSIONS: The RS model achieved poorer accuracy than the other three common machine learning models. However, the RS model provides strong interpretability and allows for the identification of high-risk factors and decision rules influencing high-risk assessments of VTE in urology. This transparency is very important for clinicians in the risk assessment process.
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Reducing doctor-patient conflict is an important part of coordinating doctor-patient disputes and easing doctor-patient relationship, which is conducive to building a harmonious medical environment and promoting the healthy development of medical undertakings. This paper constructs a multi-decision-maker mixed conflict model based on rough set theory, puts forward the matrix operation expression of the conflict degree theory in the Pawlak model, and gives a more objective and scientific evaluation function. Combined with hot issues of doctor-patient conflict, the proposed multi-decision-maker mixed conflict model is applied to doctor-patient conflict, examines the doctor-patient relationship in the medical institution system from multiple internal perspectives, and calculates feasible solutions in the conflict system. The results show that high medical quality, high standardize medication, high institutional efficiency, high staff efficiency, high hospital benefits, high hospital revenue, medium employee development, medium equipment development, or high medical quality, high standardize medication, high institutional efficiency, medium staff efficiency, medium hospital benefits, high hospital revenue, high employee development, and high equipment development are important conditions for building a harmonious medical environment and reducing doctor-patient conflicts.
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Dissidências e Disputas , Relações Médico-Paciente , Humanos , HospitaisRESUMO
Accurately and effectively detecting the growth position and contour size of apple fruits is crucial for achieving intelligent picking and yield predictions. Thus, an effective fruit edge detection algorithm is necessary. In this study, a fusion edge detection model (RED) based on a convolutional neural network and rough sets was proposed. The Faster-RCNN was used to segment multiple apple images into a single apple image for edge detection, greatly reducing the surrounding noise of the target. Moreover, the K-means clustering algorithm was used to segment the target of a single apple image for further noise reduction. Considering the influence of illumination, complex backgrounds and dense occlusions, rough set was applied to obtain the edge image of the target for the upper and lower approximation images, and the results were compared with those of relevant algorithms in this field. The experimental results showed that the RED model in this paper had high accuracy and robustness, and its detection accuracy and stability were significantly improved compared to those of traditional operators, especially under the influence of illumination and complex backgrounds. The RED model is expected to provide a promising basis for intelligent fruit picking and yield prediction.
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Governments globally face increasing pressure from climate advocates and international agreements, such as the Paris Agreement, to enact policies addressing climate change. This paper addresses the imperative for sustainable practices outlined in such agreements, with a specific focus on assessing the drivers of Green Procurement Practices (GPP) within Public Sector Organizations (PSOs). A dearth of research exists in systematically analyzing and prioritizing these drivers, exploring their interdependencies, and elucidating their relative importance. GPP is pivotal in market transformation by promoting environmentally friendly products and endorsing low-carbon, energy-efficient alternatives. This, in turn, contributes significantly to mitigating climate change and fostering a shift towards a greener, more sustainable economy. Identification of the drivers has been performed by an extensive review of the literature combined with the author's viewpoint, while the analysis has been performed using the novel method of Dominance-based Rough Set Approach (DRSA) and Interpretive Structural Modelling (ISM) with Matriced' Impacts Croise's Multiplication Applique'e a UN Classement (MICMAC) analysis. The study's outcome reveals that the Demand for Eco-friendly products is the primary driver for the incorporation of GPP, followed by the drivers' Presence of guidelines support and Government Regulations. Findings of the research also demonstrate that suppliers' propensity to adopt green practices depends on several factors, including sustainable supplier cooperation, degree of commitment to embrace green initiatives, government interventions in the form of incentives and guidelines support, and the presence of a legal framework. The findings of this research will enrich the understanding of policymakers and managers to formulate strategies for advancing GPP structured and sustainable implementation in PSOs. The study's findings will also benefit green technology sector advancement through the widespread adoption of GPP.
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Organizações , Setor Público , Governo , Motivação , ParisRESUMO
Humans are a vision-dominated species; what we perceive depends on where we look. Therefore, eye movements (EMs) are essential to our interactions with the environment, and experimental findings show EMs are affected in neurodegenerative disorders (ND). This could be a reason for some cognitive and movement disorders in ND. Therefore, we aim to establish whether changes in EM-evoked responses can tell us about the progression of ND, such as Alzheimer's (AD) and Parkinson's diseases (PD), in different stages. In the present review, we have analyzed the results of psychological, neurological, and EM (saccades, antisaccades, pursuit) tests to predict disease progression with machine learning (ML) methods. Thanks to ML algorithms, from the high-dimensional parameter space, we were able to find significant EM changes related to ND symptoms that gave us insights into ND mechanisms. The predictive algorithms described use various approaches, including granular computing, Naive Bayes, Decision Trees/Tables, logistic regression, C-/Linear SVC, KNC, and Random Forest. We demonstrated that EM is a robust biomarker for assessing symptom progression in PD and AD. There are navigation problems in 3D space in both diseases. Consequently, we investigated EM experiments in the virtual space and how they may help find neurodegeneration-related brain changes, e.g., related to place or/and orientation problems. In conclusion, EM parameters with clinical symptoms are powerful precision instruments that, in addition to their potential for predictions of ND progression with the help of ML, could be used to indicate the different preclinical stages of both diseases.
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Doenças Neurodegenerativas , Doença de Parkinson , Humanos , Movimentos Oculares , Doenças Neurodegenerativas/diagnóstico , Teorema de Bayes , Doença de Parkinson/diagnóstico , Aprendizado de MáquinaRESUMO
Point cloud data generated by LiDAR sensors play a critical role in 3D sensing systems, with applications encompassing object classification, part segmentation, and point cloud recognition. Leveraging the global learning capacity of dot product attention, transformers have recently exhibited outstanding performance in point cloud learning tasks. Nevertheless, existing transformer models inadequately address the challenges posed by uncertainty features in point clouds, which can introduce errors in the dot product attention mechanism. In response to this, our study introduces a novel global guidance approach to tolerate uncertainty and provide a more reliable guidance. We redefine the granulation and lower-approximation operators based on neighborhood rough set theory. Furthermore, we introduce a rough set-based attention mechanism tailored for point cloud data and present the rough set transformer (RST) network. Our approach utilizes granulation concepts derived from token clusters, enabling us to explore relationships between concepts from an approximation perspective, rather than relying on specific dot product functions. Empirically, our work represents the pioneering fusion of rough set theory and transformer networks for point cloud learning. Our experimental results, including point cloud classification and segmentation tasks, demonstrate the superior performance of our method. Our method establishes concepts based on granulation generated from clusters of tokens. Subsequently, relationships between concepts can be explored from an approximation perspective, instead of relying on specific dot product or addition functions. Empirically, our work represents the pioneering fusion of rough set theory and transformer networks for point cloud learning. Our experimental results, including point cloud classification and segmentation tasks, demonstrate the superior performance of our method.
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Environmental deterioration, the COVID-19 pandemic and the Russian-Ukrainian conflict had brought chronic and dramatic impacts on agricultural supply chain around the world, resulting in high inflation rates and unavoidable costs. In order to reduce the adverse impacts and achieve sustainability in agricultural supply chain, it's necessary to scientifically explore composite indicators interlinked with agricultural sustainable supply chain management (ASSCM). The current study developed an integrated rough-fuzzy WINGS-ISM method to reveal the hierarchal and causal structure of indicators. It is found that environmental legislation, regulation, licensing, and government subsidies are the main drivers of ASSCM. Specifically, the government can guide the sustainable development of ASSCM by regulating the business environment. The financial support needs to be enlarged to optimize the structure in science and technology of ASSCM. Moreover, corporates and organizations are highly motivated by the increasing awareness of social responsibility and sustainability consciousness to improve the economic performance and achieve the ASSCM goals. A comparative analysis is proposed to illustrate the practicality and reliability of the results obtained from the proposed method, which can be utilized as a reference in ASSCM.
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Recently, an exciting experimental conclusion in Li et al. (Knowl Inf Syst 62(2):611-637, 1) about measures of uncertainty for knowledge bases has attracted great research interest for many scholars. However, these efforts lack solid theoretical interpretations for the experimental conclusion. The main limitation of their research is that the final experimental conclusions are only derived from experiments on three datasets, which makes it still unknown whether the conclusion is universal. In our work, we first review the mathematical theories, definitions, and tools for measuring the uncertainty of knowledge bases. Then, we provide a series of rigorous theoretical proofs to reveal the reasons for the superiority of using the knowledge amount of knowledge structure to measure the uncertainty of the knowledge bases. Combining with experiment results, we verify that knowledge amount has much better performance for measuring uncertainty of knowledge bases. Hence, we prove an empirical conclusion established through experiments from a mathematical point of view. In addition, we find that for some knowledge bases that cannot be classified by entity attributes, such as ProBase (a probabilistic taxonomy), our conclusion is still applicable. Therefore, our conclusions have a certain degree of universality and interpretability and provide a theoretical basis for measuring the uncertainty of many different types of knowledge bases, and the findings of this study have a number of important implications for future practice.
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Pawlak's classical model of rough set approximations provides an efficient tool for extracting information exactly by employing available knowledge (i.e., known knowledge) in an information system, since many problems in rough set theory are NP-hard and their solution process is therefore greedy and approximate. Many extensions of Pawlak's classical model have been proposed in recent years. Most of them are considered over one or two sets, that is, one- or two-dimensional space or one- or two-dimensional data. Aided by relation-based rough set models, a few of these extensions are considered over three sets. However, the real world is in three-dimensional space. Therefore, it is necessary to solve these problems with other models, such as covering rough set models. For this purpose, we propose the TP-matroid-a matroidal structure over three sets. Employing the family of feasible sets of a TP-matroid as the available knowledge, a pair of rough set approximations-lower and upper approximations-is provided. In addition, for an information system defined over three sets, assisted by formal concept analysis, we establish a pair of rough set approximations. Furthermore, two TP-matroids are established based on the above pair of rough set approximations. The integration between the two pairs of rough set approximations presented here is discussed. The results show that for an information system in three-dimensional space, the rough set approximations provided here can effectively explore unknown knowledge by using available knowledge based on the family of feasible sets of a TP-matroid.
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Due to the explosive growth of data collected by various sensors, it has become a difficult problem determining how to conduct feature selection more efficiently. To address this problem, we offer a fresh insight into rough set theory from the perspective of a positive approximation set. It is found that a granularity domain can be used to characterize the target knowledge, because of its form of a covering with respect to a tolerance relation. On the basis of this fact, a novel heuristic approach ARIPA is proposed to accelerate representative reduction algorithms for incomplete decision table. As a result, ARIPA in classical rough set model and ARIPA-IVPR in variable precision rough set model are realized respectively. Moreover, ARIPA is adopted to improve the computational efficiency of two existing state-of-the-art reduction algorithms. To demonstrate the effectiveness of the improved algorithms, a variety of experiments utilizing four UCI incomplete data sets are conducted. The performances of improved algorithms are compared with those of original ones as well. Numerical experiments justify that our accelerating approach enhances the existing algorithms to accomplish the reduction task more quickly. In some cases, they fulfill attribute reduction even more stably than the original algorithms do.
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AlgoritmosRESUMO
In recent years, due to the ubiquitous presence of WiFi access points in buildings, the WiFi fingerprinting method has become one of the most promising approaches for indoor positioning applications. However, the performance of this method is vulnerable to changes in indoor environments. To tackle this challenge, in this paper, we propose a novel WiFi fingerprinting method that uses the valued tolerance rough set theory-based classification method. In the offline phase, the conventional received signal strength (RSS) fingerprinting database is converted into a decision table. Then a new fingerprinting database with decision rules is constructed based on the decision table, which includes the credibility degrees and the support object set values for all decision rules. In the online phase, various classification levels are applied to find out the best match between the RSS values in the decision rules database and the measured RSS values at the unknown position. The experimental results compared the performance of the proposed method with those of the nearest-neighbor-based and the random statistical methods in two different test cases. The results show that the proposed method greatly outperforms the others in both cases, where it achieves high accuracy with 98.05% of right position classification, which is approximately 50.49% more accurate than the others. The mean positioning errors at wrong estimated positions for the two test cases are 1.71 m and 1.99 m, using the proposed method.
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AlgoritmosRESUMO
The pandemic outbreak of severe acute respiratory syndrome caused by the Coronavirus 2 disease in 2019, also known as SARS-COV-2 and COVID-19, has claimed over 5.6 million lives till now. The highly infectious nature of the Covid-19 virus has resulted into multiple massive upsurges in counts of new infections termed as 'waves.' These waves consist of numerous rising and falling counts of Covid-19 infection cases with changing dates that confuse analysts and researchers. Due to this confusion, the detection of emergence or drop of Covid waves is currently a subject of intensive research. Hence, we propose an algorithmic framework to forecast the upcoming details of Covid-19 infection waves for a region. The framework consists of a displaced double moving average ( δ DMA) algorithm for forecasting the start, rise, fall, and end of a Covid-19 wave. The forecast is generated by detection of potential dates with specific counts called 'markers.' This detection of markers is guided by decision rules generated through rough set theory. We also propose a novel 'corrected moving average' ( χ SMA) technique to forecast the upcoming count of new infections in a region. We implement our proposed framework on a database of Covid-19 infection specifics fetched from 12 countries, namely: Argentina, Colombia, New Zealand, Australia, Cuba, Jamaica, Belgium, Croatia, Libya, Kenya, Iran, and Myanmar. The database consists of day-wise time series of new and total infection counts from the date of first case till 31st January 2022 in each of the countries mentioned above. The δ DMA algorithm outperforms other baseline techniques in forecasting the rise and fall of Covid-19 waves with a forecast precision of 94.08%. The χ SMA algorithm also surpasses its counterparts in predicting the counts of new Covid-19 infections for the next day with the least mean absolute percentage error (MAPE) of 36.65%. Our proposed framework can be deployed to forecast the upcoming trends and counts of new Covid-19 infection cases under a minimum observation window of 7 days with high accuracy. With no perceptible impact of countermeasures on the pandemic until now, these forecasts will prove supportive to the administration and medical bodies in scaling and allotment of medical infrastructure and healthcare facilities.
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Methods and techniques of feature selection support expert domain knowledge in the search for attributes, which are the most important for a task. These approaches can also be used in the process of closer tailoring of the obtained solutions when dimensionality reduction is aimed not only at variables but also at learners. The paper reports on research where attribute rankings were employed to filter induced decision rules. The rankings were constructed through the proposed weighting factor based on the concept of decision reducts-a feature reduction mechanism embedded in the rough set theory. Classical rough sets operate only in discrete input space by indiscernibility relation. Replacing it with dominance enables processing real-valued data. Decision reducts were found for both numeric and discrete attributes, transformed by selected discretisation approaches. The calculated ranking scores were used to control the selection of decision rules. The performance of the resulting rule classifiers was observed for the entire range of rejected variables, for decision rules with conditions on continuous values, discretised conditions, and also inferred from discrete data. The predictive powers were analysed and compared to detect existing trends. The experiments show that for all variants of the rule sets, not only was dimensionality reduction possible, but also predictions were improved, which validated the proposed methodology.
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In recent years, research on applications of three-way decision (e.g., TWD) has attracted the attention of many scholars. In this paper, we combine TWD with multi-attribute decision-making (MADM). First, we utilize the essential idea of TOPSIS in MADM theory to propose a pair of new ideal relation models based on TWD, namely, the three-way ideal superiority model and the three-way ideal inferiority model. Second, in order to reduce errors caused by the subjectivity of decision-makers, we develop two new methods to calculate the state sets for the two proposed ideal relation models. Third, we employ aggregate relative loss functions to calculate the thresholds of each object, divide all objects into three different territories and sort all objects. Then, we use a concrete example of building appearance selection to verify the rationality and feasibility of our proposed models. Furthermore, we apply comparative analysis, Spearman's rank correlation analysis and experiment analysis to illustrate the consistency and superiority of our methods.
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In this paper, based on the results of rough set theory, test theory, and exact learning, we investigate decision trees over infinite sets of binary attributes represented as infinite binary information systems. We define the notion of a problem over an information system and study three functions of the Shannon type, which characterize the dependence in the worst case of the minimum depth of a decision tree solving a problem on the number of attributes in the problem description. The considered three functions correspond to (i) decision trees using attributes, (ii) decision trees using hypotheses (an analog of equivalence queries from exact learning), and (iii) decision trees using both attributes and hypotheses. The first function has two possible types of behavior: logarithmic and linear (this result follows from more general results published by the author earlier). The second and the third functions have three possible types of behavior: constant, logarithmic, and linear (these results were published by the author earlier without proofs that are given in the present paper). Based on the obtained results, we divided the set of all infinite binary information systems into four complexity classes. In each class, the type of behavior for each of the considered three functions does not change.
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BACKGROUND: Current methods in machine learning provide approaches for solving challenging, multiple constraint design problems. While deep learning and related neural networking methods have state-of-the-art performance, their vulnerability in decision making processes leading to irrational outcomes is a major concern for their implementation. With the rising antibiotic resistance, antimicrobial peptides (AMPs) have increasingly gained attention as novel therapeutic agents. This challenging design problem requires peptides which meet the multiple constraints of limiting drug-resistance in bacteria, preventing secondary infections from imbalanced microbial flora, and avoiding immune system suppression. AMPs offer a promising, bioinspired design space to targeting antimicrobial activity, but their versatility also requires the curated selection from a combinatorial sequence space. This space is too large for brute-force methods or currently known rational design approaches outside of machine learning. While there has been progress in using the design space to more effectively target AMP activity, a widely applicable approach has been elusive. The lack of transparency in machine learning has limited the advancement of scientific knowledge of how AMPs are related among each other, and the lack of general applicability for fully rational approaches has limited a broader understanding of the design space. METHODS: Here we combined an evolutionary method with rough set theory, a transparent machine learning approach, for designing antimicrobial peptides (AMPs). Our method achieves the customization of AMPs using supervised learning boundaries. Our system employs in vitro bacterial assays to measure fitness, codon-representation of peptides to gain flexibility of sequence selection in DNA-space with a genetic algorithm and machine learning to further accelerate the process. RESULTS: We use supervised machine learning and a genetic algorithm to find a peptide active against S. epidermidis, a common bacterial strain for implant infections, with an improved aggregation propensity average for an improved ease of synthesis. CONCLUSIONS: Our results demonstrate that AMP design can be customized to maintain activity and simplify production. To our knowledge, this is the first time when codon-based genetic algorithms combined with rough set theory methods is used for computational search on peptide sequences.
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Peptídeos Catiônicos Antimicrobianos , Aprendizado de Máquina , Sequência de Aminoácidos , Resistência Microbiana a Medicamentos , Proteínas Citotóxicas Formadoras de PorosRESUMO
This paper presents the results of structure-activity relationship (SAR) studies of 140 3,3'-(α,ω-dioxaalkan)bis(1-alkylimidazolium) chlorides. In the SAR analysis, the dominance-based rough set approach (DRSA) was used. For analyzed compounds, minimum inhibitory concentration (MIC) against strains of Staphylococcus aureus and Pseudomonas aeruginosa was determined. In order to perform the SAR analysis, a tabular information system was formed, in which tested compounds were described by means of condition attributes, characterizing the structure (substructure parameters and molecular descriptors) and their surface properties, and a decision attribute, classifying compounds with respect to values of MIC. DRSA allows to induce decision rules from data describing the compounds in terms of condition and decision attributes, and to rank condition attributes with respect to relevance using a Bayesian confirmation measure. Decision rules present the most important relationships between structure and surface properties of the compounds on one hand, and their antibacterial activity on the other hand. They also indicate directions of synthesizing more efficient antibacterial compounds. Moreover, the analysis showed differences in the application of various parameters for Gram-positive and Gram-negative strains, respectively.
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Antibacterianos , Imidazóis , Pseudomonas aeruginosa/crescimento & desenvolvimento , Staphylococcus aureus/crescimento & desenvolvimento , Antibacterianos/química , Antibacterianos/farmacologia , Imidazóis/química , Imidazóis/farmacologia , Relação Estrutura-AtividadeRESUMO
Contamination of urban water distribution systems (WDS) is a critical issue due to the number of victims that might be impacted in a short period of time. Any effective rapid emergency response plan for reducing the number of sick people or deaths among those drinking the polluted water requires a reliable forecast of the water contamination zoning map (CZM). The water CZM is a visual representation of the spread of contamination at the time of contamination detection. This study presents a novel methodology based on the rough set theory (RST) for real-time forecasting of the CZM caused by simultaneous multi-point contamination injection in WDS. Our proposed methodology consists of (i) a Monte Carlo simulation model to capture the uncertainties in a multi-point deliberate contamination, (ii) a numerical simulation model for simulating pipe flow, and (iii) a rough set-based technique for real-time CZM for a WDS equipped with a set of monitoring stations. The proposed methodology can be used for any type of random contamination of WDSs as well as emergencies in deliberate contamination of water distribution networks.
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Emergências , Água , Monitoramento Ambiental , Humanos , Qualidade da Água , Abastecimento de ÁguaRESUMO
Feature selection is one of the core contents of rough set theory and application. Since the reduction ability and classification performance of many feature selection algorithms based on rough set theory and its extensions are not ideal, this paper proposes a feature selection algorithm that combines the information theory view and algebraic view in the neighborhood decision system. First, the neighborhood relationship in the neighborhood rough set model is used to retain the classification information of continuous data, to study some uncertainty measures of neighborhood information entropy. Second, to fully reflect the decision ability and classification performance of the neighborhood system, the neighborhood credibility and neighborhood coverage are defined and introduced into the neighborhood joint entropy. Third, a feature selection algorithm based on neighborhood joint entropy is designed, which improves the disadvantage that most feature selection algorithms only consider information theory definition or algebraic definition. Finally, experiments and statistical analyses on nine data sets prove that the algorithm can effectively select the optimal feature subset, and the selection result can maintain or improve the classification performance of the data set.
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The vulnerability of water resources is an important criterion for evaluating the carrying capacity of water resources systems under the influence of climate change and human activities. Moreover, assessment and prediction of river basins' water resources vulnerability are important means to assess the water resources security state of river basins and identify possible problems in future water resources systems. Based on the constructed indicator system of water resources vulnerability assessment in Song-Liao River Basin, this paper uses the neighborhood rough set (abbreviated as NRS) method to reduce the dimensionality of the original indicator system to remove redundant attributes. Then, assessment indicators' standard values after dimensionality reduction are taken as the evaluation sample, and the random forest regression (abbreviated as RF) model is used to assess the water resources vulnerability of the river basin. Finally, based on data under three different future climate and socio-economic scenarios, scenario predictions are made on the vulnerability of future water resources. The results show that the overall water resources vulnerability of the Song-Liao River Basin has not improved significantly in the past 18 years, and the overall vulnerability of the Song-Liao River Basin is in the level V of moderate to high vulnerability. In the future scenario 1, the overall water resources vulnerability of the river basin will improve, and it is expected to achieve an improvement to the level III of moderate to low vulnerability. At the same time, the natural vulnerability and vulnerability of carrying capacity will increase significantly in the future, and the man-made vulnerability will increase slowly, which will deteriorate to the level V of moderate to high vulnerability under Scenario 3. Therefore, taking active measures can significantly reduce the vulnerability of nature and carrying capacity, but man-made vulnerability will become a bottleneck restricting the fragility of the overall water resources of the river basin in the future.