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1.
Proc Natl Acad Sci U S A ; 121(33): e2403950121, 2024 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-39116137

RESUMO

Miniaturized reconstructive spectrometers play a pivotal role in on-chip and portable devices, offering high-resolution spectral measurement through precalibrated spectral responses and AI-driven reconstruction. However, two key challenges persist for practical applications: artificial intervention in algorithm parameters and compatibility with complementary metal-oxide-semiconductor (CMOS) manufacturing. We present a cutting-edge miniaturized reconstructive spectrometer that incorporates a self-adaptive algorithm referenced with Fabry-Perot resonators, delivering precise spectral tests across the visible range. The spectrometers are fabricated with CMOS technology at the wafer scale, achieving a resolution of ~2.5 nm, an average wavelength deviation of ~0.27 nm, and a resolution-to-bandwidth ratio of ~0.46%. Our approach provides a path toward versatile and robust reconstructive miniaturized spectrometers and facilitates their commercialization.

2.
Mol Cell Proteomics ; 22(7): 100590, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-37301378

RESUMO

Ovarian cancer, a leading cause of cancer-related deaths among women, has been notoriously difficult to screen for and diagnose early, as early detection significantly improves survival. Researchers and clinicians seek routinely usable and noninvasive screening methods; however, available methods (i.e., biomarker screening) lack desirable sensitivity/specificity. The most fatal form, high-grade serous ovarian cancer, often originate in the fallopian tube; therefore, sampling from the vaginal environment provides more proximal sources for tumor detection. To address these shortcomings and leverage proximal sampling, we developed an untargeted mass spectrometry microprotein profiling method and identified cystatin A, which was validated in an animal model. To overcome the limits of detection inherent to mass spectrometry, we demonstrated that cystatin A is present at 100 pM concentrations using a label-free microtoroid resonator and translated our workflow to patient-derived clinical samples, highlighting the potential utility of early stage detection where biomarker levels would be low.


Assuntos
Detecção Precoce de Câncer , Neoplasias Ovarianas , Humanos , Animais , Feminino , Cistatina A , Neoplasias Ovarianas/metabolismo , Micropeptídeos
3.
Nano Lett ; 24(34): 10467-10474, 2024 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-39096282

RESUMO

Spin-mechanical coupling is vital in diverse fields including spintronics, sensing, and quantum transduction. Two-dimensional (2D) magnetic materials provide a unique platform for investigating spin-mechanical coupling, attributed to their mechanical flexibility and novel spin orderings. However, studying their spin-mechanical coupling presents challenges in probing mechanical deformation and thermodynamic property changes at the nanoscale. Here we use nano-optoelectromechanical interferometry to mechanically detect the phase transition and magnetostriction effect in multilayer CrSBr, an air-stable antiferromagnet with large magnon-exciton coupling. The transitions among antiferromagnetism, spin-canted ferromagnetism, and paramagnetism are visualized. Nontrivial magnetostriction coefficient 2.3 × 10-5 and magnetoelastic coupling strength on the order of 106 J/m3 have been found. Moreover, we demonstrate the substantial tunability of the magnetoelastic constant by nearly 50% via gate-induced strain. Our findings demonstrate the strong spin-mechanical coupling in CrSBr and pave the way for developing sensitive magnetic sensing and efficient quantum transduction at the atomically thin limit.

4.
Nano Lett ; 2024 Apr 09.
Artigo em Inglês | MEDLINE | ID: mdl-38593087

RESUMO

Flatband localization endowed with robustness holds great promise for disorder-immune light transport, particularly in the advancement of optical communication and signal processing. However, effectively harnessing these principles for practical applications in nanophotonic devices remains a significant challenge. Herein, we delve into the investigation of on-chip photonic localization in AB cages composed of indirectly coupled microring lattices. By strategically vertically shifting the auxiliary rings, we successfully introduce a magnetic flux of π into the microring lattice, thereby facilitating versatile control over the localization and delocalization of light. Remarkably, the compact edge modes of this structure exhibit intriguing topological properties, rendering them strongly robust against disorders, regardless of the size of the system. Our findings open up new avenues for exploring the interaction between flatbands and topological photonics on integrated platforms.

5.
Nano Lett ; 24(40): 12390-12397, 2024 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-39311406

RESUMO

Single photon emitters (SPEs) in hexagonal boron nitride (hBN) are elementary building blocks for room-temperature on-chip quantum photonic technologies. However, fundamental challenges, such as slow radiative decay and nondeterministic placement of the emitters, limit their full potential. Here, we demonstrate large-area arrays of plasmonic nanoresonators (PNRs) for Purcell-induced room-temperature SPEs by engineering emitter-cavity coupling and enhancing radiative emission. Gold-coated silicon pillars with an alumina spacer enable a 10-fold local-field enhancement in the emission band of native hBN defects. We observe bright SPEs with an average saturated emission rate surpassing 5 million counts per second, an average lifetime of <0.5 ns, and 29% yield. Density functional theory reveals the beneficial role of an alumina spacer between hBN and gold, mitigating the electronic broadening of emission from defects proximal to the metal. Our results offer arrays of bright, heterogeneously integrated single-photon sources, paving the way for robust and scalable quantum information systems.

6.
Nano Lett ; 24(35): 11043-11050, 2024 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-39162252

RESUMO

Coupled nanomechanical resonators have unveiled fascinating physical phenomena, including phonon-cavity coupling, coupled energy decay pathway, avoided crossing, and internal resonance. Despite these discoveries, the mechanisms and control techniques of nonlinear mode coupling phenomena with internal resonances require further exploration. Here, we report on the observation of stochastic switching between the two resonance states with coupled 1:1 internal resonance, for resonant two-dimensional (2D) molybdenum disulfide (MoS2) nanoelectromechanical systems (NEMS), which is directly driven to the critical coupling regime without parametric pumping. We further demonstrate that the probability of state switching is linearly tunable from ∼0% to ∼100% by varying the driving voltage. Furthermore, we gradually increase the white noise amplitude and show that the probability of obtaining the higher-energy state decreases, and the stochastic switching phenomenon eventually disappears. The results provide insights into the dynamics of coupled NEMS resonators and open up new possibilities for sensing and stochastic computing.

7.
Small ; 20(27): e2308814, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38282203

RESUMO

There is a recent resurgence of interest in phage therapy (the therapeutic use of bacterial viruses) as an approach to eliminating difficult-to-treat infections. However, existing approaches for therapeutic phage selection and virulence testing are time-consuming, host-dependent, and facing reproducibility issues. Here, this study presents an innovative approach wherein integrated resonant photonic crystal (PhC) cavities in silicon are used as optical nanotweezers for probing and manipulating single bacteria and single virions with low optical power. This study demonstrates that these nanocavities differentiate between a bacterium and a phage without labeling or specific surface bioreceptors. Furthermore, by tailoring the spatial extent of the resonant optical mode in the low-index medium, phage distinction across phenotypically distinct phage families is demonstrated. The work paves the road to the implementation of optical nanotweezers in phage therapy protocols.


Assuntos
Bacteriófagos , Pinças Ópticas , Vírion , Bacteriófagos/fisiologia
8.
Philos Trans A Math Phys Eng Sci ; 382(2279): 20240150, 2024 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-39129411

RESUMO

The introduction of metamaterials has provided new possibilities to manipulate the propagation of waves in different fields of physics, ranging from electromagnetism to acoustics. However, despite the variety of configurations proposed so far, most solutions lack dynamic tunability, i.e. their functionality cannot be altered post-fabrication. Our work overcomes this limitation by employing a photo-responsive polymer to fabricate a simple metamaterial structure and enable tuning of its elastic properties using visible light. The structure of the metamaterial consists of graded resonators in the form of an array of pillars, each giving rise to different resonances and transmission band gaps. Selective laser illumination can then tune the resonances and their frequencies individually or collectively, thus yielding many degrees of freedom in the tunability of the filtered or transmitted wave frequencies, similar to playing a keyboard, where illuminating each pillar corresponds to playing a different note. This concept can be used to realize low-power active devices for elastic wave control, including beam splitters, switches and filters.This article is part of the theme issue 'Current developments in elastic and acoustic metamaterials science (Part 2)'.

9.
Sensors (Basel) ; 24(7)2024 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-38610317

RESUMO

Differential photoacoustic spectroscopy (DPAS) cells are usually excited on the first longitudinal ring mode, with a microphone situated in the middle of each of the two resonator tubes. However, it is known from other photoacoustic spectroscopy cell designs that connecting the microphones via a capillary can lead to signal enhancement. By means of finite element method (FEM) simulations, we compared such a photoacoustic spectroscopy (PAS) cell with a capillary to a DPAS cell with a capillary attached to each of the two resonators and showed that the behavior of both systems is qualitatively the same: In both the PAS and the DPAS cell, in-phase and anti-phase oscillations of the coupled system (resonator-capillary) can be excited. In the DPAS cell, capillaries of suitable length also increase the pressure signal at the microphones according to the FEM simulations. For different capillary diameters (1.2 mm/1.7 mm/2.2 mm), the respective optimal capillary length (36-37.5 mm) and signal amplification was determined (94%, 70%, 53%). According to the results of these FEM simulations, a significant increase in sensitivity can, therefore, also be achieved in DPAS cells by expanding them with thin tubes leading to the microphones.

10.
Sensors (Basel) ; 24(8)2024 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-38676096

RESUMO

We propose and study a nanoscale strong coupling effect between metamaterials and polymer molecular vibrations using metallic split-ring resonators (SRRs). Specifically, we first provided a numerical investigation of the SRR design, which was followed by an experimental demonstration of strong coupling between mid-infrared magnetic dipole resonance supported by the SRRs fabricated on a calcium fluoride substrate and polymethyl methacrylate molecular vibrations at 1730 cm-1. Characterized by the anti-crossing feature and spectral splitting behaviors in the transmission spectra, these results demonstrate efficient nanoscale manipulation of light-matter interactions between phonon vibrations and metamaterials.

11.
Sensors (Basel) ; 24(15)2024 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-39123924

RESUMO

This paper proposes a high-sensitivity microstrip differential sensor for measuring the complex permittivity of liquids. The prototype of the differential sensor was formed by cascading two LC resonators on a microstrip transmission line based on stepped impedance. A strong electric field was found to be distributed in the circular patch of the LC resonator; therefore, a cylindrical micropore was set in the center of the circular LC resonator to measure the dielectric sample, which maximized the disturbance of the dielectric sample on the sensor. By optimizing the size of the circular LC resonator, a high-sensitivity sensor circuit was designed and manufactured. The complex permittivity of the test sample was calculated by measuring the transmission coefficient of different molar concentrations of ethanol-water solutions. The experimental results show that the designed differential sensor can accurately measure the complex permittivity of liquid materials with an average sensitivity of 0.76%.

12.
Sensors (Basel) ; 24(5)2024 Feb 22.
Artigo em Inglês | MEDLINE | ID: mdl-38474968

RESUMO

Achieving the simultaneity of ventilation and soundproofing is a significant challenge in applied acoustics. Ventilated soundproofing relies on the interplay between local resonance and nonlocal coupling of acoustic waves within a sub-wavelength structure. However, previously studied structures possess limited types of fundamental resonators and lack modifications from the basic arrangement. These constraints often force the specified position of each attenuation peak and low absorption performance. Here, we suggest the in-duct-type sound barrier with dual Helmholtz resonators, which are positioned around the symmetry-breaking waveguides. The numerical simulations for curated dimensions and scattered fields show the aperiodic migrations and effective amplifications of the two absorptive domains. Collaborating with the subsequent reflective domains, the designed structure holds two effective attenuation bands under the first Fabry-Pérot resonance frequency. This study would serve as a valuable example for understanding the local and non-local behaviors of sub-wavelength resonating structures. Additionally, it could be applied in selective noise absorption and reflection more flexibly.

13.
Sensors (Basel) ; 24(2)2024 Jan 21.
Artigo em Inglês | MEDLINE | ID: mdl-38276369

RESUMO

We introduced a label-free sensing system based on an array of microring resonators (MRRs) which was successfully employed for human serum albumin (HSA) detection. The sensing-ring surface was functionalized to immobilize anti-HSA, facilitating HSA binding. Our refractive index sensing system demonstrates high sensitivity at 168 nm/RIU and a low limit of detection (LOD) of 63.54 ng/mL, closely comparable to current HSA detection methods. These findings confirm the potential of MRRs as biocompatible sensors for HSA detection. This system holds great promise as an innovative platform for the detection of HSA, carrying significant importance in medical diagnostics.


Assuntos
Técnicas Biossensoriais , Refratometria , Humanos , Limite de Detecção
14.
Sensors (Basel) ; 24(3)2024 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-38339739

RESUMO

This study explores the viability of using the avoided mode crossing phenomenon in the microwave regime to design microwave differential sensors. While the design concept can be applied to any type of planar electrically small resonators, here, it is implemented on split-ring resonators (SRRs). We use two coupled synchronous SRRs loaded onto a two-port microstrip line system to demonstrate the avoided mode crossing by varying the distance between the split of the resonators to control the coupling strength. As the coupling becomes stronger, the split in the resonance frequencies of the system increases. Alternatively, by controlling the strength of the coupling by materials under test (MUTs), we utilize the system as a microwave differential sensor. First, the avoided mode crossing is theoretically investigated using the classical microwave coupled resonator techniques. Then, the system is designed and simulated using a 3D full-wave numerical simulation. To validate the concept, a two-port microstrip line, which is magnetically coupled to two synchronous SRRs, is utilized as a sensor, where the inter-resonator coupling is chosen to be electric coupling controlled by the dielectric constant of MUTs. For the experimental validation, the sensor was fabricated using printed circuit board technology. Two solid slabs with dielectric constants of 2.33 and 9.2 were employed to demonstrate the potential of the system as a novel differential microwave sensor.

15.
Nano Lett ; 23(18): 8490-8497, 2023 Sep 27.
Artigo em Inglês | MEDLINE | ID: mdl-37671916

RESUMO

Near-field radiative heat transfer (NFRHT) measurements often rely on custom microdevices that can be difficult to reproduce after their original demonstration. Here we study NFRHT using plain silicon nitride (SiN) membrane nanomechanical resonators─a widely available substrate used in applications such as electron microscopy and optomechanics─and on which other materials can easily be deposited. We report measurements down to a minimal distance of 180 nm between a large radius of curvature (15.5 mm) glass radiator and a SiN membrane resonator. At such deep sub-wavelength distance, heat transfer is dominated by surface polariton resonances over a (0.25 mm)2 effective area, which is comparable to plane-plane experiments employing custom microfabricated devices. We also discuss how measurements using nanomechanical resonators create opportunities for simultaneously measuring near-field radiative heat transfer and thermal radiation forces (e.g., thermal corrections to Casimir forces).

16.
Nano Lett ; 23(10): 4344-4350, 2023 May 24.
Artigo em Inglês | MEDLINE | ID: mdl-37167540

RESUMO

One of the challenges of nanoelectromechanical systems (NEMS) is the effective transduction of the tiny resonators. Vertical structures, such as nanomechanical pillar resonators, which are exploited in optomechanics, acoustic metamaterials, and nanomechanical sensing, are particularly challenging to transduce. Existing electromechanical transduction methods are ill-suited as they put constraints on the pillars' material and do not enable a transduction of freestanding pillars. Here, we present an electromechanical transduction method for single nanomechanical pillar resonators based on surface acoustic waves (SAWs). We demonstrate the transduction of freestanding nanomechanical platinum-carbon pillars in the first-order bending and compression mode. Since the principle of the transduction method is based on resonant scattering of a SAW by a nanomechanical resonator, our transduction method is independent of the pillar's material and not limited to pillar-shaped geometries. It represents a general method to transduce vertical mechanical resonators with nanoscale lateral dimensions.

17.
Nano Lett ; 23(20): 9303-9309, 2023 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-37819876

RESUMO

Confining magnons in cavities can introduce new functionalities to magnonic devices, enabling future magnonic structures to emulate the established photonic and electronic components. As a proof-of-concept, we report magnon confinement in a lithographically defined all-on-chip YIG cavity created between two YIG/Permalloy bilayers. We take advantage of the modified magnetic properties of the covered/uncovered YIG film to define on-chip distinct regions with boundaries capable of confining magnons. We confirm this by measuring multiple spin-pumping voltage peaks in a 400 nm wide platinum strip placed along the center of the cavity. These peaks coincide with multiple spin-wave resonance modes calculated for a YIG slab with the corresponding geometry. The fabrication of micrometer-sized YIG cavities following this technique represents a new approach to control coherent magnons, while the spin-pumping voltage in a nanometer-sized Pt strip demonstrates to be a noninvasive local detector of the magnon resonance intensity.

18.
Nano Lett ; 23(14): 6301-6307, 2023 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-37460106

RESUMO

Hexagonal boron nitride (hBN) is a van der Waals material with excellent mechanical properties hosting quantum emitters and optically active spin defects, with several of them being sensitive to strain. Establishing optomechanical control of hBN will enable hybrid quantum devices that combine the spin degree of freedom with the cavity optomechanical toolbox. In this Letter, we report the first observation of radiation pressure backaction at telecom wavelengths with a hBN drum-head mechanical resonator. The thermomechanical motion of the resonator is coupled to the optical mode of a high finesse fiber-based Fabry-Pérot microcavity in a membrane-in-the-middle configuration. We are able to resolve the optical spring effect and optomechanical damping with a single photon coupling strength of g0/2π = 1200 Hz. Our results pave the way for tailoring the mechanical properties of hBN resonators with light.

19.
Nano Lett ; 23(20): 9375-9382, 2023 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-37788247

RESUMO

In resonant nanoelectromechanical systems (NEMS), the quality (Q) factor is essential for sensing, communication, and computing applications. While a large vibrational amplitude is useful for increasing the signal-to-noise ratio, the damping in this regime is more complex because both linear and nonlinear damping are important, and an accurate model for Q has not been fully explored. Here, we demonstrate that by combining the time-domain ringdown and frequency-domain resonance measurements, we extract the accurate Q for two-dimensional (2D) MoS2 and MoTe2 NEMS resonators at different vibration amplitudes. In particular, in the transition region between linear and nonlinear damping, Q can be precisely extracted by fitting to the ringdown characteristics. By varying AC driving, we tune the Q by ΔQ/Q = 269% and extract the nonlinear damping coefficient. We develop the dissipation model that well captures the linear to nonlinear damping, providing important insights for accurately modeling and optimizing Q in 2D NEMS resonators.

20.
Nano Lett ; 23(19): 8898-8906, 2023 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-37676244

RESUMO

Photonic mechanical sensors offer several advantages over their electronic counterparts, including immunity to electromagnetic interference, increased sensitivity, and measurement accuracy. Exploring flexible mechanical sensors on deformable substrates provides new opportunities for strain-optical coupling operations. Nevertheless, existing flexible photonics strategies often require cumbersome signal collection and analysis with bulky setups, limiting their portability and affordability. To address these challenges, we propose a waveguide-integrated flexible mechanical sensor based on cascaded photonic crystal microcavities with inherent deformation and biaxial tensile state analysis. Leveraging the advanced multiplexing capability of the sensor, for the first time, we successfully demonstrate 2D shape reconstruction and quasi-distributed strain sensing with 110 µm spatial resolution. Our microscale mechanical sensor also exhibits exceptional sensitivity with a detected force level as low as 13.6 µN in real-time measurements. This sensing platform has potential applications in various fields, including biomedical sensing, surgical catheters, aircraft and spacecraft engineering, and robotic photonic skin development.

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