RESUMO
Sotatercept (sotatercept-csrk; WINREVAIRTM) is an activin signalling inhibitor that is being developed by Merck and Co., Inc. (Rahway, NJ, USA) for the treatment of pulmonary arterial hypertension. Sotatercept recently received approval in the USA for the treatment of adults with pulmonary arterial hypertension [World Health Organisation (WHO) Group 1] to increase exercise capacity, improve WHO functional class and reduce the risk of clinical worsening events. This article summarizes the milestones in the development of sotatercept leading to this first approval for pulmonary arterial hypertension.
Assuntos
Aprovação de Drogas , Humanos , Proteínas Recombinantes de Fusão/uso terapêutico , Proteínas Recombinantes de Fusão/farmacologia , Estados Unidos , Ativinas/antagonistas & inibidores , Hipertensão Pulmonar/tratamento farmacológico , Hipertensão Arterial Pulmonar/tratamento farmacológicoRESUMO
Se revisan los nuevos fármacos desarrollados para el tratamiento de la anemia en la enfermedad renal crónica, junto con sus mecanismos de acción. En la actualidad, muchos de ellos se encuentran ya en fases avanzadas de ensayos clínicos y es de esperar que se incorporen al arsenal terapéutico en los próximos años. Se describen las potenciales ventajas y sus posibles limitaciones (AU)
The new drugs developed for the treatment of anemia in chronic kidney disease patients, together with their mechanisms of action are reviewed. At present, many of them are already in advanced stages of clinical trials and is expected to be incorporated into the therapeutic arsenal in the coming years. The potential benefits and possible limitations are also described (AU)