On the history of opium / Z dziejów opium.

Most likely, opium was the first narcotic substance discovered at the dawn of humankind. The history of drug addiction is immensely rich and allows for tracing the long way humankind had to travel to reach the contemporary level of consciousness with respect to narcotic substances. A retrospective view of drug addiction that takes into consideration the historical context, while extending our knowledge, also allows for a better understanding of today's problems. The report presents elements of a retrospective view of problems associated with addiction to opium, morphine and heroin over the centuries, what is a subject of scientific interest in contemporary toxicology.

[The writer Rudolf Ditzen [Hans Fallada] (1893-1947) as a morphine addict in the Stralsund Provincial Sanatorium in 1921]. / Der Schriftsteller Rudolf Ditzen [Hans Fallada] (1893-1947) als Morphinist in der Provinzial-Heilanstalt Stralsund 1921.

The work presented here analyses the in-patient psychiatric treatment, which remained unconsidered in the relevant biographies, of Rudolf Ditzen in the Stralsund Provincial Sanatorium from 5 January to 14 February 1921 with the diagnoses of "morphine addiction" and "degenerative psychopathic constitution". For this purpose the medical report on Ditzen, which has come to light again, was evaluated, and the treatment classified in its medical-historical context and the making of the diagnosis discussed against the background of Ditzen's psychosocial development. In the case of a combination of diagnoses typical for the time, against the background of Ditzen's difficult psychosocial development, which was likewise typical for its time, the result was a not entirely typical treatment for addiction under the custodial conditions of institutional psychiatry around 1920. Ditzen's hospitalisation with a comparatively mild type of symptoms is to be viewed against the background of a lack of extramural treatment structures. It is not certain whether Ditzen deliberately used the hospital as a space for withdrawal and protection.

[Argentinian women and the uses of drugs: A sociohistorical analysis of female drug use in Argentina (1860-1930)]. / Mujeres argentinas y usos de drogas: análisis sociohistórico del uso femenino de sustancias psicoactivas en Argentina (1860-1930).

This article describes cases presented by experts from the legislative and medical-legal fields regarding the use of psychoactive substances among Argentinian women from 1878 to 1930. Background information is presented regarding the relationship between women and the use different drugs, medical interventions on the female body where psychoactive substances were used are analyzed, and experts' descriptions of cases of female drug users are detailed. Experts' discourses during this period did not attempt to comprehend the specificities of female consumption, but were rather used to position the issue of drug use as a social problem. This was done using three prototypes: the victim of a sick husband; the prostitute who encourages drug use among the weak in spirit (natural-born criminals); and the virtuous young woman who succumbs to drug addiction in spite of her father's rule. Each figure reinforces the need for state intervention and increased social control.

Este trabajo describe casos expuestos por expertos de los ámbitos legislativo y médico-legal periodístico, en los que se reporta el consumo de sustancias psicoactivas por parte de mujeres de Argentina, entre 1878 y 1930. Se presentan antecedentes sobre mujeres y usos de distintos fármacos, se analizan las intervenciones médicas que utilizan sustancias psicoactivas sobre el cuerpo femenino, y se detallan los casos de mujeres consumidoras desde las miradas expertas. En este periodo, los discursos expertos no buscaron comprender la especificidad femenina del consumo, sino promover el tema drogas como un problema. Esto se produce utilizando tres prototipos: la víctima de un marido enfermo, la prostituta que envicia a los débiles de espíritu (criminal nata), y la joven virtuosa que contraviene la ley del padre y sucumbe en la toxicomanía. Cada figura refuerza la necesidad de intervención estatal y control social.

[Rudolph, crown-prince: the myth of a lost illusion]. / Rudolf trónörökös: egy elveszett illúzió mítosza.

The personality of Rudolf, the crown prince of Austria-Hungary evokes considerable interest even generations later. He had a charismatic and contradictory character that raised many hopes which he was not able to fulfill. His traumatic upbringing, the unhappy union of his parents and his mother's life-long depression all had a severe and damaging impact on him. Furthermore, his father's missing acknowledgement, Rudolf's own troubled marriage, his social isolation, alcoholism and morphine addiction along with his own depression and multiple physical illnesses have all contributed to the vulnerability of his personality. The author analyzes the developments that led to Rudolf s suicide in Mayerling and the impact of his life and death on the later myths about him.

Maestro, Marguerite, morphine: The last years in the life of Mikhail Bulgakov.

The manuscript pages of the final draft of Master i Margarita, the masterpiece by Mikhail Bulgakov, written in the last four years of his life (1936-1940), have been treated with a mixture of chromatographic beads, namely a strong cation exchanger and a C8 resin. Potential substances captured by the beads, after harvesting them, were eluted with a mixture of isopropyl alcohol, dichloromethane and ammonium hydroxide and the eluate subjected to GC-MS analysis in order to detect the presence, if any, of drugs, due to the fact that the writer suffered intense pains caused by an inherited nephrotic syndrome. Indeed all the pages under investigation (a total of ten, taken at random among 127 foils) contained traces of morphine, from as little as 5 up to 100ng/cm(2). In addition to the intact drug, we could detect one of its metabolites, namely 6-O-acetyl morphine. The significance of these findings in terms of a possible improvement of the novel and in terms of drug use (or abuse) in the modern world is discussed and evaluated. BIOLOGICAL SIGNIFICANCE: The extraction of metabolites/proteins from the surface of the original manuscript pages of Bulgakov masterpiece Master i Margarita has permitted to monitor his health state and intake of medicaments over the last four years of his life. We have ascertained that: (1) he was assuming large doses of morphine as pain killers; (2) he was affected by a nephrotic syndrome, since we could identify three proteins known as biomarkers of this pathology. The double extraction procedure here reported could open up a novel field of investigation of (relatively) ancient manuscripts for metabolome/proteome analysis on the health status of the writer/artist.

Mujeres argentinas y usos de drogas: análisis sociohistórico del uso femenino de sustancias psicoactivas en Argentina (1860-1930) / Argentinian women and the uses of drugs: A sociohistorical analysis of female drug use in Argentina (1860-1930)

RESUMEN Este trabajo describe casos expuestos por expertos de los ámbitos legislativo y médico-legal periodístico, en los que se reporta el consumo de sustancias psicoactivas por parte de mujeres de Argentina, entre 1878 y 1930. Se presentan antecedentes sobre mujeres y usos de distintos fármacos, se analizan las intervenciones médicas que utilizan sustancias psicoactivas sobre el cuerpo femenino, y se detallan los casos de mujeres consumidoras desde las miradas expertas. En este periodo, los discursos expertos no buscaron comprender la especificidad femenina del consumo, sino promover el tema drogas como un problema. Esto se produce utilizando tres prototipos: la víctima de un marido enfermo, la prostituta que envicia a los débiles de espíritu (criminal nata), y la joven virtuosa que contraviene la ley del padre y sucumbe en la toxicomanía. Cada figura refuerza la necesidad de intervención estatal y control social.

ABSTRACT This article describes cases presented by experts from the legislative and medical-legal fields regarding the use of psychoactive substances among Argentinian women from 1878 to 1930. Background information is presented regarding the relationship between women and the use of different drugs, medical interventions on the female body where psychoactive substances were used are analyzed, and experts' descriptions of cases of female drug users are detailed. Experts' discourses during this period did not attempt to comprehend the specificities of female consumption but were rather used to position the issue of drug use as a social problem. This was done using three prototypes: the victim of a sick husband; the prostitute who encourages drug use among the weak in spirit (natural-born criminals); and the virtuous young woman who succumbs to drug addiction in spite of her father's rule. Each figure reinforces the need for state intervention and increased social control.

Notes on American medical history: a follow-up study of the New Haven morphine maintenance clinic of 1920.

From 1918 to 1920, the police department of New Haven, Connecticut, operated a maintenance clinic for morphine addicts. The clinic registered 91 patrons by September 1920, when the facility was closed because of a change in federal narcotics-regulation policies. Death certificates recovered for 40 of the 91 registrants (44 per cent) show that the patrons mean age of death was 55.9 years. Although this age is 13 years younger than the mean age of death of the general population, it is comparable to the death rates for lower socioeconomic groups. The causes of death of the 40 patrons were rarely related to drugs; however, like nonaddicted persons in lower socioeconomic groups, the patrons faced higher risks of alcoholism, infectious diseases, suicide, and accidents. Thus, although many in the group appear to have freed themselves from drug addiction, they continued to face other hazards predisposing them to premature mortality.

Professionalization and narcotics: the medical and pharmaceutical professions and British narcotic use 1868-1926.

This paper analyses the influence of medical professional organization on the formation of attitudes and policies toward narcotics in England. Restrictions on sale were one corollary, and the extension of medical control helped delineate a hypodermic morphine problem and disease theories of 'inebriety'. In the period 1916-26 the Home Office attempted to impose a penal and non-professional policy. The 1926 Rolleston Report marked a compromise between medical professionalism and public policy.