Stress conditions in the host induce persister cells and influence biofilm formation by Staphylococcus epidermidis RP62A
Rev. Soc. Bras. Med. Trop
; 52: e20180001, 2019. tab, graf
Article
em En
| LILACS
| ID: biblio-1041589
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
Studies have demonstrated that pathogens react to the harsh conditions in human tissues by inducing mechanisms that promote survival.METHODS:
Persistence and biofilm-forming ability were evaluated during stress conditions that mimic those in the host.RESULTS:
Carbon-source availability had a positive effect on Staphylococcus epidermidis RP62A adhesion during hypoxia, accompanied by a decrease in pH. In contrast, iron limitation led to decreased surface-adherent biomass, accompanied by an increase medium acidification and lactate levels. Interestingly, iron starvation and hypoxia induced persister cells in planktonic culture.CONCLUSIONS:
These findings highlight the role of host stress in the virulence of S. epidermidis.Palavras-chave
Texto completo:
1
Base de dados:
LILACS
Assunto principal:
Staphylococcus epidermidis
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Virulência
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Biofilmes
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Meios de Cultura
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Interações entre Hospedeiro e Microrganismos
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article