Anti-inflammatory effects and acute oral toxicity of Copaifera spp. essential oil-loaded nanoemulsion / Efectos antiinflamatorios y toxicidad oral aguda de nanoemulsión cargada de aceite esencial de Copaifera spp
Silva, Evandro de Araújo; Prada, Ariadna Lafourcade; Boechat, Antonio Luiz; Lima, Émerson Silva; Simplício, Fernanda Guilhon; Souza, Tatiane Pereira de; Rodriguez-Amado, Jesus Rafael.
Bol. latinoam. Caribe plantas med. aromát
; 21(3): 323-342, mayo 2022. tab, ilus
Artigo
em Inglês
| LILACS | ID: biblio-1396881
Copaifera spp. essential oil (EOC) was extracted by hydrodistillation of Copaifera oleoresin (COR). The EOC was characterized by GC/MS and a novel EOC-loaded nanoemulsion was developed to enhance the EOC solubility and to evaluate its utility as antinflammatory. EOC contain 14 volatile compounds (including ß-caryophyllene 51.52%) having a required HLB of 11. The Surfactant EOC Water ratio of 131575 (%, www) produced the optimal formulation (particle size 94.47 nm). The EOC-loaded nanoemulsion presented a pseudoplastic/thixotropic behavior with excellent shelf stability for 6 months. The anti-inflammatory effect of the nanoemulsion was more potent than that of the EOC, and statistically equal to diclofenac (50 mg/kg). The EOC-loaded nanoemulsion showed no oral acute toxicity (in mice) at 2000 mg/kg; hence, it is considered a nontoxic product. The development of the EOC-loaded nanoemulsion added value to both the COR and the EOC by providinga suitable formulation that could be used as an anti-inflammatory product.
Biblioteca responsável:
CL1.1
Texto completo
Documentos relacionados