Changes in Morphology and Infectivity of Cell Culture-Derived Trypomastigotes of Trypanosoma Cruzi
Mol Biochem Parasitol
; 6(2): <s6>7</s6>- <s8>1</s8>, 1982.
Article
em En
| BVSDIP, FIOCRUZ, BIBCONTRI
| ID: dip-4434
Biblioteca responsável:
BR1719.1
Localização: BR1719.1
ABSTRACT
Trypomastigotes of Trypanosoma cruzi, obtained from the first burst of infected Vero cells, have only a limited invasive capability for fibroblastic cells. Intracellular amastigotes and epimastigotes do not infect these cells at all. Preincubation of the isolated trypomastigotes with Eagle's minimal essential medium/10 per cent fetal calf serum increases 5- to 15-fold their in vitro infectivity. This increased invasive capability is accompanied, in the case of the EP strain of T. cruzi, by a morphological transformation into an amastigote-like or spheromastigote form, which is similar, but not identical to replicating intracellular amastigotes. Trypomastigotes from another isolate (BEC) also increase their infectivity several fold upon preincubation, but before any morphological differentiation occurs, suggesting that these two events are independent.
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Coleção Fiocruz:
BVSDIP
Base de dados:
BIBCONTRI
/
BVSDIP
/
FIOCRUZ
Assunto principal:
Trypanosoma cruzi
/
Infecções
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article