MutSα expression predicts a lower disease-free survival in malignant salivary gland tumors: an immunohistochemical study
Med. oral patol. oral cir. bucal (Internet)
; 27(2): e164-e173, mar. 2022. tab, ilus, graf
Article
em En
| IBECS
| ID: ibc-204479
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Ten cases of normal salivary gland (NSG) and 92 of SGT (54 benign and 38 malignant) were retrieved. Immunohistochemistry was performed for hMSH2, hMSH3, hMSH6. Scanned slides were digitally analyzed based on the percentage of positive cells with nuclear staining. Cases were further classified in MutSαhigh and MutSβhigh based on hMSH2-hMSH6 and hMSH3-hMSH6 expression, respectively. Results: hMSH3 expression was lower in malignant SGT compared to NSG and benign cases. Adenoid cystic carcinoma (ACC) cases with perineural invasion presented a lower percentage of hMSH3 positive cells. hMSH6 was downregulated in both benign and malignant SGT compared to NSG. Malignant SGT cases with MutSαhigh expression had lower disease-free survival compared to MutSαlow cases. A 10.26-fold increased risk of presenting local recurrence was observed. Conclusions: Our findings suggest that a lack of hMSH3 protein function is associated with a more aggressive phenotype (malignancy and perineural invasion) and that MutSα overexpression predicts a poor clinical outcome in malignant SGT.(AU)
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Texto completo:
1
Base de dados:
IBECS
Assunto principal:
DNA
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Neoplasias das Glândulas Salivares
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Imuno-Histoquímica
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Intervalo Livre de Doença
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Proteína 2 Homóloga a MutS
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article