The functional role of circular RNAs in the pathogenesis of retinoblastoma: a new potential biomarker and therapeutic target?
Clin. transl. oncol. (Print)
; 25(8): 2350-2364, aug. 2023. ilus
Article
em En
| IBECS
| ID: ibc-222413
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Retinoblastoma (RB) is a common cancer in infants and children. It is a curable disease; however, a delayed diagnosis or treatment makes the treatment difficult. Genetic mutations have a central role in the pathogenesis of RB. Genetic materials such as RNAs (coding and non-coding RNAs) are also involved in the progression of the tumor. Circular RNA (circRNA) is the most recently identified RNA and is involved in regulating gene expression mainly through microRNA sponges. The dysregulation of circRNAs has been observed in several diseases and tumors. Also, various studies have shown that circRNAs expression is changed in RB tissues. Due to their role in the pathogenesis of the disease, circRNAs might be helpful as a diagnostic or prognostic biomarker in patients with RB. In addition, circRNAs could be a suitable therapeutic target to treat RB in a targeted therapy approach (AU)
Palavras-chave
Buscar no Google
Base de dados:
IBECS
Assunto principal:
Retinoblastoma
/
Neoplasias da Retina
/
MicroRNAs
Limite:
Child
/
Humans
/
Infant
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article