Spi2 gene polymorphism is not associated with recurrent airway obstruction and inflammatory airway disease in thoroughbred horses
Silva, Aline Correa da; Brass, Karin Erica; Loreto, Elgion da Silva; Vinocur, Myriam Elizabeth; Pozzobon, Ricardo; Azevedo, Marcos da Silva.
Genet. mol. biol
; 34(3): 456-458, 2011. ilus, tab
Artigo
em Inglês
| LILACS | ID: lil-595981
The aim was to detect the presence of polymorphisms at exons 1, 2, 3 and 4 of the Spi2 gene, and evaluate a possible association between them and recurrent airway obstruction (RAO) or inflammatory airway disease (IAD) in thoroughbred horses, through single-strand conformational-polymorphism (SSCP) screening. Although polymorphism was not detected in exons 1, 2 and 3, three alleles and six genotypes were identified in exon 4. The frequencies of allele A (0.6388) and genotype AA (0.3888) were higher in horses affected by RAO, although no association was found between polymorphism and horses with either RAO or IAD.
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