The SCID/Beige mouse as a model to investigate protection against Yersinia pestis.
FEMS Immunol Med Microbiol
; 23(2): 107-13, 1999 Feb.
Article
em En
| MEDLINE
| ID: mdl-10076907
ABSTRACT
In this study, we have shown that severe combined immunodeficient/beige mice reconstituted with hyperimmune Balb/c lymphocytes can be used as a model to demonstrate adoptive and passive protection against plague infection. Reconstitution of severe combined immunodeficient/beige mice was successful in nine out of ten mice as demonstrated by spleen colonisation and sustained circulating immunoglobulin titres. Furthermore, an increase in antibody titre was evident after a booster immunisation of reconstituted mice. Presence of circulating antibody correlated with protection against a systemic plague challenge and indicated that in reconstituted mice adoptive transfer of a functional immune system had occurred. The severe combined immunodeficient/beige mouse was also used to demonstrate passive protection against inhaled and systemic plague infection. The reconstituted severe combined immunodeficient/beige mouse model demonstrating protective immunity against plague will be further developed to identify the immune cell subsets responsible for this protection.
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Base de dados:
MEDLINE
Assunto principal:
Peste
/
Yersinia pestis
/
Linfócitos
/
Imunização Passiva
/
Transferência Adotiva
/
Modelos Animais de Doenças
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article