Synthetic [5,5] trans-fused indane lactones as inhibitors of thrombin.
Bioorg Med Chem Lett
; 9(3): 431-6, 1999 Feb 08.
Article
em En
| MEDLINE
| ID: mdl-10091697
ABSTRACT
Synthesis of trans-fused lactones containing the indane nucleus has resulted in a series of potent acylating inhibitors of thrombin. As an example compound 11e has an apparent second order rate constant of 11 x 10(6) M(-1)sec(-1) for the inhibition of thrombin. The anticoagulant activity of these compounds is discussed.
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Base de dados:
MEDLINE
Assunto principal:
Antitrombinas
/
Indanos
/
Lactonas
Limite:
Humans
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article