Thrombin inhibitors based on [5,5] trans-fused indane lactams.
Bioorg Med Chem Lett
; 9(12): 1657-62, 1999 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-10397495
ABSTRACT
A series of trans-fused lactams containing the indane nucleus has been prepared. Compound 19 has much enhanced plasma stability compared with its lactone counterpart and shows appreciable in vitro anticoagulant activity.
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Base de dados:
MEDLINE
Assunto principal:
Trombina
/
Indanos
/
Lactamas
/
Anticoagulantes
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article