Localization of FGFR-1 in axotomized and peripheral nerve transplanted ferret retina.
Neuroreport
; 10(18): 3903-7, 1999 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-10716231
ABSTRACT
Retinal ganglion cells (RGCs) survive axotomy and regenerate their axons into the peripheral nerve graft in adult mammals. To understand the potential role of fibroblast growth factors (FGFs) in survival and regeneration of axotomized RGCs, we examined FGF receptor 1 (FGFR-1) localization in normal and PN grafted ferret retinas by immunohistochemistry in combination with retrograde labeling. Prominent expression of FGFR-1 was observed in outer plexiform layer and ganglion cell layer of normal ferret retina. In the ganglion cell layer, FGFR-1 immunoreactivity was detected in about 30% of RGCs, predominantly in large cells. In the PN grafted ferret retina, 90% of RGCs with regenerated axons expressed FGFR-1. Our findings suggest that FGFs may play an important role in the survival and axonal regeneration of RGCs of adult mammals.
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Base de dados:
MEDLINE
Assunto principal:
Retina
/
Nervo Isquiático
/
Receptores de Fatores de Crescimento de Fibroblastos
/
Receptores Proteína Tirosina Quinases
/
Regeneração Nervosa
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article