NMDA receptor delayed maturation and schizophrenia.
Med Hypotheses
; 54(5): 693-7, 2000 May.
Article
em En
| MEDLINE
| ID: mdl-10859668
ABSTRACT
This paper presents the hypothesis that NMDA receptor delayed maturation (NRDM) may lead to the pathogenesis of schizophrenic psychotic symptoms. This hypothesis is further analyzed in the language of a neural modeling formulation. This formulation points to a possible chain of pathological events, leading from molecular-level NRDM to over-increased synaptic plasticity, and to the formation of pathological attractors, a putative macroscopic-level correlate of schizophrenic positive symptoms. The relations of the NRDM hypothesis to other alterations which are assumed to take place in schizophrenia are discussed, together with possible ways to test this hypothesis.
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Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Processamento de Proteína Pós-Traducional
/
Receptores de N-Metil-D-Aspartato
Limite:
Humans
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article