Direct coupling between meiotic DNA replication and recombination initiation.
Science
; 290(5492): 806-9, 2000 Oct 27.
Article
em En
| MEDLINE
| ID: mdl-11052944
ABSTRACT
During meiosis in Saccharomyces cerevisiae, DNA replication occurs 1. 5 to 2 hours before recombination initiates by DNA double-strand break formation. We show that replication and recombination initiation are directly linked. Blocking meiotic replication prevented double-strand break formation in a replication-checkpoint-independent manner, and delaying replication of a chromosome segment specifically delayed break formation in that segment. Consequently, the time between replication and break formation was held constant in all regions. We suggest that double-strand break formation occurs as part of a process initiated by DNA replication, which thus determines when meiotic recombination initiates on a regional rather than a cell-wide basis.
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Base de dados:
MEDLINE
Assunto principal:
Recombinação Genética
/
Saccharomyces cerevisiae
/
DNA Fúngico
/
Replicação do DNA
/
Meiose
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article